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http://dx.doi.org/10.5051/jpis.2013.43.2.79

Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study  

Gaikwad, Subodh P. (Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre)
Gurav, Abhijit N. (Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre)
Shete, Abhijeet R. (Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre)
Desarda, Hitesh M. (Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre)
Publication Information
Journal of Periodontal and Implant Science / v.43, no.2, 2013 , pp. 79-86 More about this Journal
Abstract
Purpose: The purpose of study was to compare glycemic control using glycated hemoglobin levels ($HbA_{1c}$) in diabetic patients with chronic generalized periodontitis (CGP) undergoing scaling and root planing (SRP) with and without systemic doxycycline. Methods: Fifty subjects with type 2 diabetes mellitus ($T_2DM$) and CGP receiving antidiabetic therapy were selected for study. The selected subjects were randomly assigned to two groups (test group [TG] and control group [CG]) comprising 25 patients each. The TG received SRP followed by systemic doxycycline. The CG received treatment with SRP only. The periodontal parameters were recorded at baseline (day zero), and every 1 month for 4 months and included probing depth, clinical attachment level, plaque index, gingival index, and $HbA_{1c}$ level were recorded at baseline (day zero) and at the end of 4 months. Results: A statistically significant effect was demonstrated for the periodontal parameters for both the TG and CG. $HbA_{1c}$ values did not show a statistically significant difference in the treatment group as compared to the CG. Conclusions: The authors concluded that nonsurgical periodontal therapy improved glycemic control in patients with $T_2DM$ in both groups, but no statistical difference was observed with adjunctive systemic doxycycline therapy. A further study with a larger sample size is required.
Keywords
Chronic periodontitis; Diabetes mellitus; Glycosylated hemoglobin A; Periodontal debridement;
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