1 |
Nishihara T, Koseki T. Microbial etiology of periodontitis. Periodontol 2000 2004;36:14-26.
DOI
ScienceOn
|
2 |
Dye BA. Global periodontal disease epidemiology. Periodontol 2000 2012;58:10-25.
DOI
ScienceOn
|
3 |
Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J 2009;59:197-209.
|
4 |
Manjunath BC, Praveen K, Chandrashekar BR, Rani RM, Bhalla A. Periodontal infections: a risk factor for various systemic diseases. Natl Med J India 2011;24:214-9.
|
5 |
Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991;26(3 Pt 2):230-42.
DOI
|
6 |
Matthews JB, Wright HJ, Roberts A, Cooper PR, Chapple IL. Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis. Clin Exp Immunol 2007;147:255-64.
|
7 |
Shaddox L, Wiedey J, Bimstein E, Magnuson I, Clare-Salzler M, Aukhil I, et al. Hyper-responsive phenotype in localized aggressive periodontitis. J Dent Res 2010;89:143-8.
DOI
ScienceOn
|
8 |
Feng Z, Weinberg A. Role of bacteria in health and disease of periodontal tissues. Periodontol 2000 2006;40:50-76.
DOI
ScienceOn
|
9 |
Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005;43:5721-32.
DOI
ScienceOn
|
10 |
Socransky SS, Haffajee AD. Periodontal Infections. In: Lindhe J, Karring T, Lang NP, editors. Clinical periodontology and implant dentistry. 5th ed. Oxford: Blackwell Munksgaard; 2008. p.207-67.
|
11 |
Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches. J Allergy Clin Immunol 2009;124:23-34.
DOI
|
12 |
Franke WW, Pape UF. Diverse types of junctions containing tight junction proteins in stratified mammalian epithelia. Ann N Y Acad Sci 2012;1257:152-7.
DOI
ScienceOn
|
13 |
Hatakeyama S, Yaegashi T, Oikawa Y, Fujiwara H, Mikami T, Takeda Y, et al. Expression pattern of adhesion molecules in junctional epithelium differs from that in other gingival epithelia. J Periodontal Res 2006;41:322-8.
DOI
ScienceOn
|
14 |
Dale BA, Fredericks LP. Antimicrobial peptides in the oral environment: expression and function in health and disease. Curr Issues Mol Biol 2005;7:119-33.
|
15 |
Brown KL, Hancock RE. Cationic host defense (antimicrobial) peptides. Curr Opin Immunol 2006;18:24-30.
DOI
ScienceOn
|
16 |
Marshall RI. Gingival defensins: linking the innate and adaptive immune responses to dental plaque. Periodontol 2000 2004;35:14-20.
DOI
ScienceOn
|
17 |
Chung WO, Dommisch H, Yin L, Dale BA. Expression of defensins in gingiva and their role in periodontal health and disease. Curr Pharm Des 2007;13:3073-83.
DOI
ScienceOn
|
18 |
Defraia E, Marinelli A. Oral manifestations of congenital neutropenia or Kostmann syndrome. J Clin Pediatr Dent 2001;26:99-102.
|
19 |
Pütsep K, Carlsson G, Boman HG, Andersson M. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet 2002;360:1144-9.
DOI
ScienceOn
|
20 |
Page RC. Gingivitis. J Clin Periodontol 1986;13:345-59.
DOI
|
21 |
Dixon DR, Bainbridge BW, Darveau RP. Modulation of the innate immune response within the periodontium. Periodontol 2000 2004;35:53-74.
DOI
ScienceOn
|
22 |
Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 2004;22:181-215.
DOI
ScienceOn
|
23 |
Carrassi A, Abati S, Santarelli G, Vogel G. Periodontitis in a patient with chronic neutropenia. J Periodontol 1989;60: 352-7.
DOI
|
24 |
Cainciola LJ, Genco RJ, Patters MR, McKenna J, van Oss CJ. Defective polymorphonuclear leukocyte function in a human periodontal disease. Nature 1977;265:445-7.
DOI
ScienceOn
|
25 |
Delcourt-Debruyne EM, Boutigny HR, Hildebrand HF. Features of severe periodontal disease in a teenager with Chédiak-Higashi syndrome. J Periodontol 2000;71:816-24.
DOI
ScienceOn
|
26 |
Inaloz HS, Harman M, Akdeniz S, Inaloz SS, Isik AG. Atypical familial Papillon-Lefevre syndrome. J Eur Acad Dermatol Venereol 2001;15:48-50.
DOI
ScienceOn
|
27 |
Perez HD, Kelly E, Elfman F, Armitage G, Winkler J. Defective polymorphonuclear leukocyte formyl peptide recep-tor(s) in juvenile periodontitis. J Clin Invest 1991;87:971-6.
DOI
ScienceOn
|
28 |
Raber-Durlacher JE, Epstein JB, Raber J, van Dissel JT, van Winkelhoff AJ, Guiot HF, et al. Periodontal infection in cancer patients treated with high-dose chemotherapy. Support Care Cancer 2002;10:466-73.
DOI
ScienceOn
|
29 |
Brissette CA, Simonson LG, Lukehart SA. Resistance to human beta-defensins is common among oral treponemes. Oral Microbiol Immunol 2004;19:403-7.
DOI
ScienceOn
|
30 |
Guthmiller JM, Vargas KG, Srikantha R, Schomberg LL, Weistroffer PL, McCray PB Jr, et al. Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001;45:3216-9.
DOI
ScienceOn
|
31 |
Tanaka D, Miyasaki KT, Lehrer RI. Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium. Oral Microbiol Immunol 2000;15:226-31.
DOI
ScienceOn
|
32 |
Joly S, Maze C, McCray PB Jr, Guthmiller JM. Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol 2004;42: 1024-9.
DOI
|
33 |
Nishimura E, Eto A, Kato M, Hashizume S, Imai S, Nisizawa T, et al. Oral streptococci exhibit diverse susceptibility to human beta-defensin-2: antimicrobial effects of hBD-2 on oral streptococci. Curr Microbiol 2004;48:85-7.
DOI
|
34 |
Ouhara K, Komatsuzawa H, Yamada S, Shiba H, Fujiwara T, Ohara M, et al. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. J Antimicrob Chemother 2005;55:888-96.
DOI
ScienceOn
|
35 |
Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 2000;27:648-57.
DOI
ScienceOn
|
36 |
Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-44.
DOI
ScienceOn
|
37 |
Ji S, Hyun J, Park E, Lee BL, Kim KK, Choi Y. Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils. J Periodontal Res 2007;42:410-9.
DOI
ScienceOn
|
38 |
Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res 1995;30:23-33.
DOI
ScienceOn
|
39 |
Liu RK, Cao CF, Meng HX, Gao Y. Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis. J Periodontol 2001;72:1545-53.
DOI
ScienceOn
|
40 |
Gainet J, Chollet-Martin S, Brion M, Hakim J, Gougerot-Pocidalo MA, Elbim C. Interleukin-8 production by polymorphonuclear neutrophils in patients with rapidly progressive periodontitis: an amplifying loop of polymorphonuclear neutrophil activation. Lab Invest 1998;78:755-62.
|
41 |
Sheikhi M, Gustafsson A, Jarstrand C. Cytokine, elastase and oxygen radical release by Fusobacterium nucleatum-activated leukocytes: a possible pathogenic factor in periodontitis. J Clin Periodontol 2000;27:758-62.
DOI
ScienceOn
|
42 |
Katsuragi H, Ohtake M, Kurasawa I, Saito K. Intracellular production and extracellular release of oxygen radicals by PMNs and oxidative stress on PMNs during phagocytosis of periodontopathic bacteria. Odontology 2003;91:13-8.
DOI
|
43 |
Sheikhi M, Bouhafs RK, Hammarström KJ, Jarstrand C. Lipid peroxidation caused by oxygen radicals from Fusobacterium-stimulated neutrophils as a possible model for the emergence of periodontitis. Oral Dis 2001;7:41-6.
|
44 |
Ding Y, Uitto VJ, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, et al. Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res 1996;75:1986-93.
DOI
ScienceOn
|
45 |
Ding Y, Haapasalo M, Kerosuo E, Lounatmaa K, Kotiranta A, Sorsa T. Release and activation of human neutrophil matrix metallo- and serine proteinases during phagocytosis of Fusobacterium nucleatum, Porphyromonas gingivalis and Treponema denticola. J Clin Periodontol 1997; 24:237-48.
DOI
ScienceOn
|
46 |
Yamazaki K, Polak B, Bird PS, Gemmell E, Hara K, Seymour GJ. Effects of periodontopathic bacteria on IL-1 and IL-1 inhibitor production by human polymorphonuclear neutrophils. Oral Microbiol Immunol 1989;4:193-8.
|
47 |
Weinberg A, Krisanaprakornkit S, Dale BA. Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 1998;9:399-414.
DOI
ScienceOn
|
48 |
Yoshimura A, Hara Y, Kaneko T, Kato I. Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria. J Periodontal Res 1997; 32:279-86.
DOI
ScienceOn
|
49 |
Shin J, Ji S, Choi Y. Ability of oral bacteria to induce tissue-destructive molecules from human neutrophils. Oral Dis 2008;14:327-34.
DOI
ScienceOn
|
50 |
Dale BA. Periodontal epithelium: a newly recognized role in health and disease. Periodontol 2000 2002;30:70-8.
DOI
ScienceOn
|
51 |
Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, O'Neal R, et al. Localized antimicrobial peptide expression in human gingiva. J Periodontal Res 2001; 36:285-94.
DOI
ScienceOn
|
52 |
Ji S, Kim Y, Min BM, Han SH, Choi Y. Innate immune responses of gingival epithelial cells to nonperiodontopathic and periodontopathic bacteria. J Periodontal Res 2007;42: 503-10.
DOI
ScienceOn
|
53 |
Darveau RP, Belton CM, Reife RA, Lamont RJ. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect Immun 1998;66:1660-5.
|
54 |
Huang GT, Kim D, Lee JK, Kuramitsu HK, Haake SK. Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms. Infect Immun 2001;69:1364-72.
DOI
ScienceOn
|
55 |
Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999;286:525-8.
DOI
ScienceOn
|
56 |
Ye Z, Ting JP. NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol 2008;20:3-9.
DOI
ScienceOn
|
57 |
Froy O. Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways. Cell Microbiol 2005;7:1387-97.
DOI
ScienceOn
|
58 |
Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801.
DOI
ScienceOn
|
59 |
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-9.
DOI
ScienceOn
|
60 |
Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009;10:266-72.
DOI
ScienceOn
|
61 |
Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448: 501-5.
DOI
ScienceOn
|
62 |
Ji S, Shin JE, Kim YS, Oh JE, Min BM, Choi Y. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun 2009;77:1044-52.
DOI
ScienceOn
|
63 |
Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000;68:2907-15.
DOI
ScienceOn
|
64 |
Peyret-Lacombe A, Brunel G, Watts M, Charveron M, Duplan H. TLR2 sensing of F. nucleatum and S. sanguinis distinctly triggered gingival innate response. Cytokine 2009;46:201-10.
DOI
ScienceOn
|
65 |
Chung WO, Hansen SR, Rao D, Dale BA. Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J Immunol 2004;173:5165-70.
DOI
|
66 |
Lu Q, Darveau RP, Samaranayake LP, Wang CY, Jin L. Differential modulation of human {beta}-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structures. Innate Immun 2009;15:325-35.
DOI
ScienceOn
|
67 |
Darveau RP, Pham TT, Lemley K, Reife RA, Bainbridge BW, Coats SR, et al. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun 2004;72:5041-51.
DOI
ScienceOn
|
68 |
Hashimoto M, Asai Y, Ogawa T. Separation and structural analysis of lipoprotein in a lipopolysaccharide preparation from Porphyromonas gingivalis. Int Immunol 2004;16:1431-7.
DOI
ScienceOn
|
69 |
Shin JE, Kim YS, Oh JE, Min BM, Choi Y. Treponema denticola suppresses expression of human {beta}-defensin-3 in gingival epithelial cells through inhibition of the toll-like receptor 2 axis. Infect Immun 2010;78:672-9.
DOI
ScienceOn
|
70 |
Shin JE, Choi Y. Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of TNFalpha production and TLR2 activation. Mol Cells 2010;29:407-12.
DOI
ScienceOn
|
71 |
Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, Harding CV, et al. Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci U S A 2007;104:18631-5.
DOI
ScienceOn
|
72 |
Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, et al. Discovery of new human beta-defensins using a genomics-based approach. Gene 2001;263: 211-8.
DOI
ScienceOn
|
73 |
Lu Q, Samaranayake LP, Darveau RP, Jin L. Expression of human beta-defensin-3 in gingival epithelia. J Periodontal Res 2005;40:474-81.
DOI
ScienceOn
|
74 |
Chung WO, Dale BA. Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species. Infect Immun 2004;72:352-8.
DOI
ScienceOn
|
75 |
Menzies BE, Kenoyer A. Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun 2006;74:6847-54.
DOI
ScienceOn
|
76 |
Krisanaprakornkit S, Kimball JR, Dale BA. Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family. J Immunol 2002;168:316-24.
DOI
|
77 |
Asai Y, Ohyama Y, Gen K, Ogawa T. Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect Immun 2001;69:7387-95.
DOI
ScienceOn
|
78 |
Kim Y, Jo AR, Jang da H, Cho YJ, Chun J, Min BM, et al. Toll-like receptor 9 mediates oral bacteria-induced IL-8 expression in gingival epithelial cells. Immunol Cell Biol 2012;90:655-63.
DOI
ScienceOn
|
79 |
Mikolajczyk-Pawlinska J, Travis J, Potempa J. Modulation of interleukin-8 activity by gingipains from Porphyromonas gingivalis: implications for pathogenicity of periodontal disease. FEBS Lett 1998;440:282-6.
DOI
ScienceOn
|
80 |
Deng QD, Han Y, Xia X, Kuramitsu HK. Effects of the oral spirochete Treponema denticola on interleukin-8 expression from epithelial cells. Oral Microbiol Immunol 2001; 16:185-7.
DOI
ScienceOn
|
81 |
Shin J, Choi Y. The fate of Treponema denticola within human gingival epithelial cells. Mol Oral Microbiol 2012; 27:471-82.
DOI
ScienceOn
|
82 |
Hajishengallis G, Wang M, Liang S, Triantafilou M, Triantafilou K. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci U S A 2008;105:13532-7.
DOI
ScienceOn
|
83 |
Lambris JD, Ricklin D, Geisbrecht BV. Complement evasion by human pathogens. Nat Rev Microbiol 2008;6:132-42.
DOI
ScienceOn
|
84 |
Flannagan RS, Cosio G, Grinstein S. Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol 2009;7:355-66.
DOI
ScienceOn
|
85 |
Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, et al. The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J Immunol 2011; 186:869-77.
DOI
ScienceOn
|
86 |
Hajishengallis G, Shakhatreh MA, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol 2007;179:2359-67.
DOI
|