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MMP-1 promoter polymorphism in Korean with generalized aggressive periodontitis  

Oh, Hyong-Suk (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University)
Kim, Ok-Su (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University)
Kim, Young-Jun (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University, 2nd stage of BK 21 project, School of Dentistry, Chonnam National University)
Chung, Hyun-Ju (Department of Periodontology, School of Dentistry and Dental Science Research Institute, Chonnam National University, 2nd stage of BK 21 project, School of Dentistry, Chonnam National University)
Publication Information
Journal of Periodontal and Implant Science / v.39, no.sup2, 2009 , pp. 269-278 More about this Journal
Abstract
Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status. Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by ${\chi}^2$ test. Results: There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position - 519 of MMP-1 gene promoter (P<0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P< 0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P< 0.05). Conclusions: The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.
Keywords
aggressive periodontitis; genetic polymorphism; matrix metalloproteinase 1;
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