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Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect  

Park, Jung-Chul (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Lim, Hyun-Chang (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Sohn, Joo-Yeon (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Yun, Jeong-Ho (Department of Dentistry, College of Medicine, Kwandong University, Myongji Hospital)
Jung, Ui-Won (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Kim, Chang-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Cho, Kyoo-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Kim, Chong-Kwan (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
Publication Information
Journal of Periodontal and Implant Science / v.39, no.sup2, 2009 , pp. 223-230 More about this Journal
Abstract
Purpose: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and ${\beta}$-tricalcium phosphate (${\beta}$- TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP. Methods: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and ${\beta}$- TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and ${\beta}$-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed. Results: BCP with HAand ${\beta}$- TCP 8 weeks group and BCP with Si-HA and ${\beta}$- TCP 4 and 8 weeks groups showed statistically significant in crease (P <0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and ${\beta}$- TCP 8 weeks group. Conclusions: Based on histological results, BCP with HA and ${\beta}$- TCP and BCP with Si-HA and ${\beta}$- TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.
Keywords
bone substitutes; hydroxyapatite wound healing;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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