Browse > Article

The effect of non-surgical treatment in gingival enlargement  

Kim, Sang-Jun (Department of Periodontology, School of Dentistry, Kangnung National University)
Lee, Jae-Kwan (Department of Periodontology, School of Dentistry, Kangnung National University)
Um, Heung-Sik (Department of Periodontology, School of Dentistry, Kangnung National University)
Chang, Beom-Seok (Department of Periodontology, School of Dentistry, Kangnung National University)
Publication Information
Journal of Periodontal and Implant Science / v.39, no.1, 2009 , pp. 103-108 More about this Journal
Abstract
Purpose: It is well recognized that gingival enlargement is induced by unwanted effect associated with three major drugs/drug groups - phenytoin, cyclosporine, and the calcium channel blockers. The present case report describes the effect and limitation of non-surgical treatment in gingival enlargement cases. Materials and methods: Three cases included 2 drug-influenced gingival enlargement patients and a idiopathic gingival fibromatosis patient. For the drug-influenced gingival enlargement patients, the medication was replaced with other medication. And then, all the patients were treated non-surgically. Results: Drug-influenced gingival enlargements had been reduced after non-surgical treatment and the results were well-maintained. In the idiopathic gingival fibromatosis case, non-surgical treatment resulted in only limited reduction of gingival enlargement, and surgical periodontal treatment was unavoidable. Conclusion: These case reports indicated that non-surgical periodontal treatment with change in medication was effective in the treatment of drug-influenced gingival enlargements. Non-surgical approach can be considered as the primary management to reduce the gingival enlargement. If non-surgical treatment encounters a limitation, surgical treatment should be considered.
Keywords
gingival enlargement; overgrowth; nifedipine; non-surgical treatment;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug-induced gingival overgrowth. J Clin Periodontol 2006;33:433-439
2 Casetta I, Granieri E, Desidera M et al. Phenytoin-induced gingival overgrowth: A community-based cross-sectional study in Ferrara, Italy. Neuroepidemiology 1997;16:296-303   DOI   ScienceOn
3 Nakou M, Kamma n, Andronikaki A, Mitsis F. Subgingival microflora associated with nifedipine-induced gingival overgrowth. J Periodontol 1998;69:664-669   DOI   PUBMED   ScienceOn
4 Seymour RA, Smith DG. The effect of a plaque control programme on the incidence and severity of cyclosporin- induced gingival changes. J Clin Periodontol 1991;18: 107-110   DOI   PUBMED
5 Lewis IK, Hanlon JT, Schmader KE et al. Use of medications with potential oral adverse drug interactions in community-dwelling elderly. Spec Care Dentist 1993;13: 171-176   DOI   ScienceOn
6 Aimetti M, Romano F, Marsico A, Navone R. Non-surgical periodontal treatment of cyclosporin A-induced gingival overgrowth: immunohistochemical results. Oral Dis 2008;14(3): 244-250   DOI   ScienceOn
7 Academy report: Drug-associated gingival enlargement. J Periodontol 2004;75:1424-1431   DOI   PUBMED   ScienceOn
8 Fu E, Nieh S, Wikesjo UM, The effect of plaque retention on cyclosprine-induced gingival overgrowth in rats. J Periodontol 1997;68:92-98   DOI   PUBMED   ScienceOn
9 Somacarrera ML, Lucas M, Scully C et al. Effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth in transplant patients. British Dental Journal 1997;183:89-94   DOI   PUBMED   ScienceOn
10 Kim WK, Baek J, Lee YK. The effect of periodontal therapy on the gingival thickness in patients with drug-induced gingival enlargement. J Korean Acad Periodontol 2005;35(4) :1109-1116   DOI
11 Barak S, Engelberg I, Hiss Z. Gingival hyperplasia caused by nifedipine: Histopathological findings. J Periodontol 1987;58:639-642   DOI   PUBMED
12 Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza's Clinical Periodontology, 10th ed. Philadelphia: W.B. Saunders; 2006:373-390
13 Hancock RH, Swan RH. Nifedipine-induced gingival overgrowth. J Clin Periodontol 1992;19: 12-14   DOI   ScienceOn
14 Ellis IS, Seymour Ra, Steele JG et al. Prevalence of gingival overgrowth induced by calcium channel blockers: A community-based study. J Periodontol 1999;70:63-67   DOI   ScienceOn
15 Boltchi FE, Rees TD, Iacopino AM. Cyclosporine A-induced gingival overgrowth: A comprehensie review. Quintessence lnt 1999;30:775-783
16 Rees TD, Levine RA. Systemic drugs as a risk factor for periodontal disease initiation and progression. Compend Contin Educ Dent 1995;16:20-42