Browse > Article

The effect of maintenance period of non-resorbable membrane on bone regeneration in rabbit calvarial defects  

Jung, Min-Gu (Department of Periodontology, College of Dentistry, Chosun University)
Jang, Hyun-Seon (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute)
Kim, Byung-Ock (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute)
Publication Information
Journal of Periodontal and Implant Science / v.37, no.3, 2007 , pp. 543-551 More about this Journal
Abstract
When clinicians faced with an insufficient volume of supporting bone on ideally esthetic and bio-mechanical position for dental implantation, guided bone regeneration(GBR) was indicated. Although GBR has wide application at clinic, proper time of membrane removal remains qustionable in using non-resorbable membrane, such as non-expanded polytetrafluoroethylene(PTFE), The aim of this study was to compare the effect of maintenance period of PTFE membrane on bone regeneration in rabbit calvarial defects. Eight adult New Zealand white female rabbits were used in this study. Four defects were surgically made in their calvaria. Using a trephine bur, 4 'through and through' defects were created and classified into 3 groups, which were consisted of control group(no graft), experimental group 1(autogenous bone)and experimental group 2(deproteinized bovine bone; $OCS-B^{(R)}$). The defects were covered with PTFE membrane($Cytoplast^{(R)}$). Membranes were removed after 1, 2, 4 and 8 weeks post-GBR procedure in 2 rabbits repectively, All rabbits were sacrificed after 8 week post-GBR procedure. Specimens were harvested and observed histologically. The results were as follow; 1) The use of graft material and membrane was necessary in GBR procedure. 2) When PTFE membranes were removed early, the most favorable bone regeneration was revealed in experimental group T, followed by experimental group II and control group. 3) On GBR, it is recommended that membrane should maintain for 4 weeks with autogenous graft. As well, the use of xenograft need longer maintenance period than autogenous bone. Further evaluations will be needed, such as histomorphologic research, more species and different kinds of graft materials. And on the basis of these studies, clinical researches would be required.
Keywords
Guided bone regonoration(GBR); PTFE membrane; membrane maintenace period;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Hurley AL, Stinchfield FE, Bassett CAL and Lyon WH, The role of soft tissues in osteotenesis. J Bone Joint Surg 1959;41A: 1243
2 Boyne PJ. Restoration of osseous defects in maxillofacial casualties, J Am Dent Assoc 1969;78: 769
3 Bartee BK. The use of high-density polytetrafluoroethylene membrane to treat osseous defects: Clinical reports. Implant Dent 1995:4:21-26   DOI   PUBMED   ScienceOn
4 Steinhauser E, Hardt N, Secondary reconstriction of cranial defects, J Maxillofac Surg 1985:5:192-198   DOI   ScienceOn
5 Garg AK. Bone Bone biology, harvesting and grafting for dental implants. Quintessence 2005:21-56
6 Hosokawa R, Natio T, Yokota M, Uchida Y, Long-term placement of Gore-Tex membrane over an alveolar bone defect followed by dental implant restoration: A case report-evaluation of the membrane regenerated bone maturation, J Jpn Prosthodont Soc 1995:39:19-26   DOI
7 Scantlebury TV, 1982-1992: A decade of technology development for guided tissue regeneration. J Periodontal 1993:64:1129-1137
8 Jovanovic SA, Schenk RK, Orsini M, Supracrestal bone formation around dental implants: An experimental dog study. Int J Oral Maxillofac Implants 1995:10:23-31
9 Anson D. Calcium sulfate: A 4-year observation of its use as a resorbable barrier in guided tissue regeneration of periodontal defects. Compend Contin Educ Dent 1996; 17:895-899
10 Jackson IT. HeIden G. Marx R. Skull bone grafts in maxillofacial and craniofacial surgery. J Oral Maxillofac Surg 1986:44: 949-960   DOI   PUBMED
11 Curtis TA, Ware DH. Autogenous bone graft procedures for atophic edentulous mandibles, J Prosthe Dent 1977:38:366-379   DOI   ScienceOn
12 Boyne PJ, Mikels TE, Restoration of alveolar ridges by intramandibular transposition osseous grafting. J Oral Surg 1968;26:569   PUBMED
13 Nyman S, Gottlow J, Karring T, Lindhe J. The regenerative potential of the periodontal ligament: An experimental study in the monkey. J Clin Periodontal 1982;9:257-265   DOI
14 Swart LGN. Allard RHB. Subperiosteal onlay augmentation of the mandible: A dincial and radiographic survey. J Oral Maxillofac Surg 1985:43:183-187   DOI   ScienceOn
15 Ho-nam Park, Sang-hyuk Han, Kyounghwa Kim, Sang-chul Lee, Yoon-jeong Park, Sang-hoon Lee, Tae-il Kim, Yang -jo Seol, Young Ku, ln-ichul Rhyu, Soo-boo Han, Chong-pyoung Chung, A study on the safety and efficacy of bovine bone-derived bone graft material, The journal of korean academy of periodontology 2005;35(2):335-343   DOI
16 Misch CE, Dietsh F. Bone-grafting materials in implant dentistry. Implant Dent 1993: 2:158-167   DOI   PUBMED   ScienceOn
17 Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontal 1982; 9: 290-296   DOI
18 Dahlin C, Andersson L, Lindhe A. Bone augmentation at fenestrated implants by osteopromotive membrane technique: A controlled clinical study, Clin Oral Implants Res 1991; 2:159-165   DOI   ScienceOn
19 Boyne PJ, Autogneous cancellous bone and marrow transplants. J Clin Orthopedics 1970: 73: 199-212
20 Becker W, Becker BE, Mellonig J, A prospective multi-center study evaluating periodontal regeneration for Class II fureation invasions and intrabony defects after treatment with a bioabsorbable barrier membrane: l-ryear results J Periodontal 1996;67 :641-649   DOI   ScienceOn
21 Hardwick R, Hayes BK, Flynn C Devices for dentoalveolar regeneration: An up-to-date literature review. J Periodontol 1995; 66:495-505   DOI   PUBMED   ScienceOn
22 Block MS, Kent JN, Ardoin RC. Davenport W, Mandibular augmentation in dogs with hydroxylapatite combined with demineralized hone J Oral Maxillofac Surg 1987:15: 414-420
23 Ohnishi H, Fujii N. Futami T, Taguchi N, Kusakari H, Maeda T. A histochemical investigation of the' bone formation process by guided bone regeneration in rat jaws. Effect of PTFE membrane application periods on newly formed bone. J Periodontol 2000:71(3) :341-52   DOI   ScienceOn
24 Jensen SS, Broggini N, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorgranic bovine bone and $\beta$-trecalcium phosphate: a histologic and histornorphometric study in tho mandibles of mini pigs. Clin Oral Implants Res 2006: 17(3):237-213   DOI   ScienceOn
25 Payne JM, Cobb CM, Rapley JM, Killoy WJ, Spencer P, Migration of human gingival fibroblasts over guided tissue regeneration barrier materials. J Periodontal 1996:67: 236-244   DOI
26 Meffert RM. Guided tissue regeneration/ guided bone regeneration: A review of the barrier membranes. Pract Periodontics Aesthet Dent 1996:8:142-144   PUBMED
27 Bassett CAL, Environmental and cellular factors regulating osteogenesis, Bone Biodynamics. Boston: Little Brown. 1996: 233-244
28 Boyne PJ, Regeneration of alveolar bone beneath cellulose acetate filter filter implants, J Dent Res 1964;43:827
29 Buser D, Dura K, Belser U, Hirt H, Berthold H, Localized ridge augmentation using guided bone regeneration, 1. Surgical procedure in the maxilla, lnt J Periodontics Restorative Dent 1993:13:29-45
30 Yukna CN, Yukna RA. Multi-center evaluation of bioabsorbable collagen membrane for guided tissue regeneration in human Class II furcations, J Periodontal 1996;67: 650-657   DOI   ScienceOn
31 Buser D, Ruskin J, Higginbottom F, Hardwick R. Dahlin C, Osseointegration of titanium implants in bone regenerated in membrane-protected defects: A histologic study in the canine mandible. Int J Oral Maxillofac Implants 1995:10:666-681
32 Hupp JT. McKenna SJ. Use of porous hydroxylapatite blocks for augmentation of atrophic mandibles. J Oral Maxillofac Surg 1988: 46: 538-545   DOI   ScienceOn
33 Melcher AH, Dreyer CJ, Protection of the blood clot in healing circumscribed bone defects, J Bone Joint Surg 1962:44B:424-430