Browse > Article

Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived Xeonograft  

Kim, Young-Taek (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Chae, Gyung-Joon (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Jung, Ui-Won (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Lee, Yong-Kun (Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University)
Cho, Kyoo-Sung (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Chai, Jung-Kiu (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Kim, Chong-Kwan (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Choi, Seong-Ho (Department of Periodontology, College of dentistry, Yonsei University, Research Institute for Periodontal Regeneration)
Publication Information
Journal of Periodontal and Implant Science / v.37, no.3, 2007 , pp. 489-496 More about this Journal
Abstract
The ultimate goal of periodontal treatment is to regenerate the lost periodontal apparatus. Many studies were performed in developing an ideal bone substitute. Anorganic bovine-derived xenograft is one of the bone substitute, which were studied and have been shown successful for decades. The aim of this study is to evaluate the effect anorganic bovine-derived xenograft. Total of 20 patients, with 10 patients receiving only modified widman flap, and the other 10 receiving anorganic bovine-derived xenograft and flap surgery, were included in the study. Clinical parameters were recorded before surgery and after 6 months. The results are as follows: 1. The test group treated with anorganic bovine-derived xenograft showed reduction in periodontal pocket depth and clinical attachment level with statistically significance(p<0.001) after 6 months. The control group treated with only modified Widman flap showed reduction only in periodontal pocket depth with statistically significance(p<0.001) after 6 months. 2. Although periodontal probing depth change during 6 months did not show any significant differences between the test group and the control group, clinical attachment level gain and re-cession change showed significant differences between the two groups(p<0.05). On the basis of these results, anorganic bovine-derived xenograft improves probing depth and clinical attachment level in periodontal intrabony defects. Anorganic bovine-derived xenograft could be a predictable bone substitute in clinical use.
Keywords
intrabony defect; periodontal regeneration; clinical attachment level; xenograft;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Hoexter DL, Bone regeneration graft materials, J Oral Implantol 2002:28:290-294   DOI   ScienceOn
2 Buck BE, Malinin TI, Brown MD, Bone transplantation and human immunodeficiency virus. An estimate of risk of acquired immunodeficiency syndrome (AIDS). Gin Orthop Relat Res 1989:29-136
3 Moon IS, Chai JK, Cho KS, Wikesjo UM, Kim CK, Effects of polyglactin mesh combined with resorbable calcium carbonate or replamineform hydroxyapatite on periodontal repair in dogs. J Clin Periodontal 1996:23:945-951   DOI   ScienceOn
4 Young C, Sandstedt P, Skoglund A, A comparative study of anorganic xenogenic bone and autogenous bone implants for bone regeneration in rabbits. Int J Oral Maxillofac Implants 1999:14:72-76
5 박호남, 안상혁, 김경화. et al. 생체 유래 골이식재(OCS-B)의 안정성및 유효성에 관한 연구. 대한치주과학회지 2005;35:335-343
6 Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects Int J Periodontics Restorative Dent 1984:4:40-55   PUBMED
7 Carranza FA, Newman MG, Takei HH, Klokkevold PR, Carranza's Clinical Periodontology: Sanders; 2006: 579-608
8 Zohar R, Tenenbaum HC. How predictable are periodontal regenerative procedures? J Can Dent Assoc 2005;71:675-680   PUBMED
9 Rosen PS, Reynolds MA.. Bowers GM, The treatment of intrabony defects with bone grafts, Periodontal 2000;22:88-103   DOI   ScienceOn
10 Hartman GA, Arnold RM, Mills MP, Cochran DL, Mellonig JT, Clinical and histologic evaluation of anorganic bovine bone collagen with or without a collagen barrier, lnt J Periodontics Restorative Dent 2004; 24:127-135
11 Asher DM. Padilla AM, Pocchiari M. WHO Consultation on Diagnostic Procedures for Transmissible Spongiform Encephalopathies: Need for Reference Reagents and Reference Panels. Geneva, Switzerland, 22-23 March 1999. Biologicals 1999:27:265-272
12 Hyun SJ, Han DK, Choi SH, et al, Effect of recombinant human bone morphogenetic protcin-2, -4, and -7 on bone formation in rat calvarial defects J Periodontol 2005: 76:1667-1674   DOI   ScienceOn
13 Han DK, Kim CS, Jung UW, et al. Effect of a fibrin-fibronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects. J Periodontal 2005: 76:2216-2222   DOI   ScienceOn
14 Sculcan A, Berakdar M, Chiantella GC, et al Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled dinical study. J Clin Periodontal 2003:30:73-80   DOI   ScienceOn
15 Rosling B, Nyman S, Lindhe J, Jern B. The healing potential of the periodontal tissues following different techniques of periodontal surgery in plaque-free dentitions, A 2-year clinical study, J Clin Periodontol 1976;3:233-250   DOI
16 Kim CS, Choi SH. Cho KS. et al Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral -derived biomaterial, J Gin Periodontal 2005:32:583-589   DOI   ScienceOn
17 Froum SJ, Coran M, Thaller B, et al, Periodontal healing following open debridement flap procedures, I. Clinical assessment of soft tissue and osseous repair. J Periodontol 1982;53:8-14   DOI   PUBMED
18 김현수, 최병갑, 최성호, 조규성, 서종진. BBP가 치주 골내낭 치유에 미치는 영향. 대한치주과학회지 2002;32:213-224
19 김성희, 김종관, 채중규, 조규성, 골내 치주낭에서 탈회냉동건조골 동종이식시 이식효과에 대한 임상적 연구. 대한치주과학회지 1994:24:618-633
20 Pang EK, Im SU, Kim CS, et al Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model J Periodontol 2004; 75:1364-1370   DOI   ScienceOn
21 Richardson CR. Mellonig JT, Brunsvold MA, McDonnell HT, Cochran DL, Clinical evaluation of Bio-Oss: a bovine-derived xenograft for the treatment of periodontal osseous defects in humans, J Clin Periodontol 1999:26:421-428   DOI   ScienceOn
22 Kim CK, Cho KS, Choi SH, Prewett A, Wikesjo UM. Periodontal repair in dogs: effect of allogenic freeze-dried demineralized bone matrix implants on alveolar bone and cementum regeneration, J Periodontol 1998:69:26-33   DOI   PUBMED   ScienceOn
23 Jensen SS. Broggini N, Hjorting- Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate, A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2006:17:237-243   DOI   ScienceOn
24 Wang HL, Greenwell H, Fiorellini J, et al, Periodontal regeneration. J Periodontol 2005;76:1601-1622   DOI
25 Pinholt EM, Bang G, Haanaes HR. Alveolar ridge augmentation in rats by Bio-Oss, Scand J Dent Res 1991;99:154-161   PUBMED
26 Sogal A, Tofe AJ. Risk assessment of bovine spongiforrn encephalopathy transmission through bone graft material derived from bovine bone used for dental applications, J Periadontol 1999;70:1053-1063   DOI
27 Sculean A, Chiantella GC, Windisch P, et al, Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO) , J Clin Periodontal 2005:32:720-724   DOI   ScienceOn
28 Mellonig JT, Human histologic evaluation of a bovine-derived bone xenograft in the treatment of periodontal osseous defects, Int J Periodontics Restorative Dent 2000: 20:19-29   PUBMED
29 Fucini SE, Quintero G, Gher ME, Black BS, Richardson AC, Small versus large particles of demineralized freeze-dried bone allografts in human intrabony periodontal defects. J Periodontol 1993;64:844-847   DOI   PUBMED   ScienceOn
30 Westfelt E. Bragd L, Socransky SS, et al, Improved periodontal conditions following therapy. J Clin Periodontol 1985;12:283-293   DOI
31 Sculean A, Stavropoulos A, Windisch P, et al, Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration. Clin Oral Investig 2004;8:70-74   PUBMED
32 Shapoff CA, Bowers GM, Levy B, Mellonig JT, Yukna RA, The effect of particle size on the osteogenic activity of composite grafts of allogeneic freeze-dried bone and autogenous marrow, J Periodontal 1980;51: 625-630   DOI
33 Zander HA, Polson AM, Heijl LC. Goals of periodontal therapy, J Periodontal 1976:47:261-266   DOI
34 Mellonig JT. Donor selection, testing. and inactivation of the HIV virus in freezedried bone allografts. Pract Periodontics Aesthet Dent 1995:7:13-22; quiz 23   PUBMED
35 Kim CK, Choi EJ, Cho KS, Chai JK, Wikesjo UM. Periodontal repair in intrabony defects treated with a calcium carbonate implant and guided tissue regeneration. J Periodontol 1996:67:1301-1306   DOI   PUBMED   ScienceOn