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Histologic evaluation of the regenerated bone using bone graft materials  

Ryu, Ho-Chul (Department of Periodontology, School of Dentistry, Kyung Hee University)
Park, Joon-Bong (Department of Periodontology, School of Dentistry, Kyung Hee University)
Kwon, Young-Hyuk (Department of Periodontology, School of Dentistry, Kyung Hee University)
Herr, Yeek (Department of Periodontology, School of Dentistry, Kyung Hee University)
Chung, Jong-Hyuk (Department of Periodontology, School of Dentistry, Kyung Hee University)
Jue, Seong-Suk (Department of Oral Anatomy, School of Dentistry, Kyung Hee University)
Publication Information
Journal of Periodontal and Implant Science / v.36, no.2, 2006 , pp. 289-303 More about this Journal
Abstract
This study was performed to evaluate the effect of bone graft materials including demineralized freeze-dried bone, freeze-dried bone, deproteinized bovine bone on space-making capacity and bone formation in guided bone regeneration with titanium reinforced ePTFE membrane(TR-ePTFE). Adult male rabbits(mean BW 2kg) were used in this study. Intramarrow penetration defects were surgically created with round bur on calvaria of rabbits. TR-ePTFE membrane was adapted to calvarial defect and bone graft materials were placed. Animals were sacrificed at 2, 8, 12 weeks after surgery. Non-decalcified specimens were processed for histologic analysis and prepared with Villaneuva bone stain. The results of this study were as follows: 1. TR-ePTFE membrane was biocompatible and capable of maintaining the space-making. 2. Tissue integration was not good at TR-ePTFE membrane. Fixation was not enough. so, wound stabilization was not good. 3. In animals using deproteinized bovine bone, demineralized freeze-dried bone, bone formation was little. 4. In animals using freeze-dried bone, bone formation was better. Within the above results, bone formation may be inhibited when wound stabilizafion was not good.
Keywords
Guided bone regeneration; Titanium reinforced ePTFE membrane; Bone graft materials;
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