Browse > Article

A comparative study of the clinical effects of chitosan nanofiber membrane in the treatment of mandibular class II furcation defects  

Choi, Han-Sun (Department of Periodontology, College of Dentistry, Dan-Kook University)
Jeong, Lim (Nibec Co., Ltd)
Kim, Jeong-Bin (Nibec Co., Ltd)
Hong, Ki-Seok (Department of Periodontology, College of Dentistry, Dan-Kook University)
Lim, Sung-Bin (Department of Periodontology, College of Dentistry, Dan-Kook University)
Chung, Chin-Hyung (Department of Periodontology, College of Dentistry, Dan-Kook University)
Publication Information
Journal of Periodontal and Implant Science / v.35, no.3, 2005 , pp. 703-718 More about this Journal
Abstract
The purpose of this study was to evaluate the clinical efficacy of guided tissue regeneration(GTR) technique using chitosan nanofiber membrane and to compare it to the clinical efficacy following GTR using PLA/PLGA(copolymer of polvlactic acid and polylacticglycolic acid) membrane in mandibular class II furcation defects in human. The chitosan nanofiber membranes were applied to the mandibular class II furcation defects of 13 patients(test group) and PLA/PLGA membranes were applied to those of 11 patients(control group). Probing pocket depth, clinical attachment level, gingival recession, plaque index and gingival index were measured at baseline and 3 months postoperatively. Vertical and horizontal furcation defect depth were measured at surgery. Both groups were statistically analyzed by Wilcoxon signed Ranks Test and Mann-Whitney Test using SPSS program. The results were as follows: 1. Probing pocket depth, clinical attachment loss and gingival index were significantly reduced at 3 months postoperatively compared to values of baseline in both groups(p<0.05). 2. Gingival recession and plaque index were not significantly decreased at 3 months postoperatively compared to values of baseline in both groups. 3. No significant difference between two groups could be detected with regard to changes of probing pocket depth, gingival recession, clinical attachment level, plaque index and gingival index at 3 months postoperatively. In conclusion, chitosan nanofiber membrane is effective in the treatment of human mandibular class II furcation defects and a longer period study is needed to fully evaluate the outcomes.
Keywords
NanoGide-C; chitosan nanofiber membrane; Biomesh; guided tissue regeneration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Parashis A, Anagnou-Vareltzides A, Demetriou N. Calculus removal from multirooted teeth with and without surgical access. J Clin Periodontol 1993;20:294-298   DOI   ScienceOn
2 Becker W, Becker B. Berg L, Prichard J, Caffesse R, Resenberg E. New attachment after treatment with root isolation and vertical osseous defects. lnt J Periondontics Restorative Dent 1988:8:8-23
3 Gottlow J, Karring T. Maintenance of new attachment gained through guided tissue regeneration. J Clin Periodontol 1992:19:315-317   DOI   PUBMED
4 Scantlebury TV. A decade of technology development for guided tissue regeneration. J Periodontol 1993:64(11 suppl): 1129-1137   DOI   PUBMED   ScienceOn
5 Selvig KA, Kersten BG. Wikesho UME. Surgical treatment of intrabony periodontal defects using expanded polytetrafluoroethylene barrier membranes: influence of defect configuration on healing response. J Periodontol 1993:64: 730-733   DOI   PUBMED   ScienceOn
6 Hugoson A, Ravalk N, Formell J, Johard G, Teiwik A, Gottlow J. Treatment of class II furcation involvements in humans with bioresorbable and nonresorbable guided tissue regeneration barriers. A randomized multi-center study. J Periodontol 1995: 66: 624-634   DOI   PUBMED   ScienceOn
7 Becker W. Becker BD, Melloning J, Caffesse RG, Warrer K, Caton JG, Reid T. A prospective multi-center study evaluation periodontal regeneration for class II furcation invasions and intrabony defects after treatment with a bioabsorbable barrier membrane: 1-year results. J Periodontol 1996:67:641-649   DOI   PUBMED   ScienceOn
8 Kind GM. Bines SD, Staren ED, Templeton AJ, Economou SG. Chitosan: evaluation of a new hemostatic agent. Curr Surg 1990:47:37-39   PUBMED
9 Klokkevold PR. Subar P, Fukayama H, Bertolami CN. Effect of chitosan on lingual hemostasis in rabbits with platelet dysfunction induced by epoprostenol. J Oral Maxillofac Surg 1992: 50:41-45   DOI   ScienceOn
10 Muzzarelli RA. Biagini G. Pugnaloni A. Filippini O. Baldassarre V. Reconstruction of periodontal tissue with chitosan. Biomaterials 1989; 10: 598-603   DOI   ScienceOn
11 Iglhaut J, Suggs C, Borjesson B, Aukhil I. Apical migration of oral epithelium in experimental dehiscence wounds. J Clin Periodontol 1987; 14: 508-514   DOI   PUBMED
12 Hench LL. Biomaterials. Science 1980, 23:208(4446) :826-31. Review
13 Blumenthal NM. A clinical comparison of collagen membranes with e-PTFE membranes in the treatment of human mandibular buccal class II furcation defects. J Periodontol 1993:64:925-933   DOI   PUBMED   ScienceOn
14 Murphy K.G. Postoperative healing complication associated with Gore-Tex periodontal material. Part I. Incidence and characterization. Int J Periodont Rest Dent 1995; 15: 363-375
15 Klokkevold PR. Lew DS, Ellis DG, Bertolami CN. Effect of chitosan on lingual hemostasis in rabbits. J Oral Maxillofac Surg 1991:49:858-863   DOI   ScienceOn
16 백정원, 이현정, 유윤정, 조규성, 김종관, 최성호. 키토산이 치주인대 섬유아세포에 미치는 영향. 대한치주과학회지 2001; 31(4) : 823-832
17 Dahlin C. Lindhe A. Gottlow J. Nyman S. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988; 81: 672-676   DOI   PUBMED   ScienceOn
18 Kalkwarf K. Kadahl WE. Patel KD. Evaluation of fur cation region response to periodontal therapy. J Periodontol 1988: 59: 794-804   DOI   PUBMED
19 Nyman S, Gottlow J, Lindhe J, Karring T. Wennstrom J. New attachment formation by guided tissue regeneration. J Periodont Res 1987: 22: 252-254   DOI   PUBMED
20 Matia JI. Bissada NF. Maybury JE. Efficiency of scaling of the molar furcation area with and without surgical access. Int J Periodontics Restorative Dent 1986:6:25-35
21 Klokkevold PR. Vandermark L, Kenney EB, Bernard GW. Osteogenesis enhanced by chitosan(Poly-N-Acetyl Glucosaminoglycan) in vitro. J Periodontol 1996:67: 1170-1175   DOI   PUBMED   ScienceOn
22 Silness J. Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964:22:121-135   DOI   ScienceOn
23 Shigemasa Y. Saito K. Sashiwa H. Saimoto H. Enzymatic degradation of chitins and partially deacetylated chitins. Int J Biol Macromol 1994: 16:43-49   DOI   ScienceOn
24 Lekovic V, Kenney EB, Kovacevic K. Carranza Jr. F.A. Evaluation of guided tissue regeneration in class II furcation defects. A clinical re-entry study. J Periodontol 1989: 60: 694-698   DOI   PUBMED
25 Muzzarelli RA, Mattioli-Belmote M, Tiez C, Biagini R, Feriolo G, Brunelli MA, Fini M, Giardino R, Ilari P, Biagini G. Stimulatory effect on bone formation exerted by a modified chitosan. Biomaterials 1994:15:1075-1081   DOI   ScienceOn
26 Pontorieto R, Nyman S, Lindhe J, Rosenberg E, Sanavi F. Guided tissue regeneration in the treatment of furcation defects in man. J Clin Periodontol 1987:14:618-620   DOI   PUBMED
27 Onishi H. Machida Y. Biodegradation and distribution of water-soluble chitosan in mice. Biomaterials 1999:20: 175-82   DOI   ScienceOn
28 Socransky SS. Haffajee AD. Goodson JM. Linde J. New concepts of destructive periodontal disease. J Clin Periodontol 1984: 11:21-32   DOI   PUBMED
29 Wang H, Burgett F. Shyr Y. Ramfyord S. The influence of molar furcation involvement and mobility on future clinical periodontal attachment loss. J Periodontol 1994:65:25-29   DOI   PUBMED   ScienceOn
30 Pontoriero R, Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F. Guided tissue regeneration in degree II furcation-involved mandibular molars. A clinical study. J Clin Periodontol 1988: 15 :247-254   DOI   PUBMED
31 Mima S, Miya M. Iwamoto R, Yoshikawa S. Highly deacetylated chitosan and its properties. J Appl Polym Sci 1983:28: 1909-1917   DOI   ScienceOn
32 Caffesse RG, Nasjleti CE, Morrison EC, Sanchez R. Guided tissue regeneration: comparison of bioabsorbable and nonbioabsorbable membranes. Histologic and histometric study in dogs. J Periodontol 1994:65: 583-591   DOI   PUBMED   ScienceOn
33 Becker W, Becker BE, McGuire MK. Localized ridge augmentation using absorbable pins and e-PTFE barrier membranes: a new surgical technique. Case reports. lnt J Periodontics Restorative Dent 1994: 14: 48-61
34 Azad AK, Sermsintham N, Chandrkrachang S, Stevens WF. Chitosan membrane as a wound healing dressing: characterization and clinical application. J Biomed Mater Res 2004: 69B: 216-222   DOI
35 Aspinall GO. The polysaccharides. Chitin and chitosan. New York: Academic Press 1983: Inc.2: 386
36 계승범, 손성희, 최상묵. Chitosan과 chitosan-cellulose를 이용한 차폐막의 골조직 재생유도 능력에 관한 연구. 대한치주과학회지. 1998;28 :611-32
37 Minami S, Okamoto A Matsuhashi A. et al. Applications of chitin and chitosan in animals. In: Brine CJ, Sanford PA Zikakis JP, eds. Advanced in chitin and chitosan. London: Elsevier Applied Science 1992:61-69
38 Gottlow J. Nyman S. Lindhe J, Karring T, Wennstrom J. New attachment formation in the human periodontium by guided tissue regeneration. Case reports. J Clin Periodontol 1986: 13:604-616   DOI   PUBMED
39 Warrer K. Karring T, Nyman S, Gogolewski S. Guided tissue regeneration using biodegradable membranes of polylactic acid or polyurethane. J Clin Periodontol 1992; 9: 633-640
40 Loe H. The gingival index. the plaque index and the retention index systems. J Periodontol 1974:38:610-616   DOI
41 Dahlin C. Andersson L, Lindhe A. Bone augmentation at fenestrated implants by an osteopromotive membrane technique. A controlled clinical study. Clin Oral Implants Res 1991:2: 159-65   DOI   ScienceOn
42 Melcher AH. On the repair potential of periodontal tissue. J Periodontol 1976: 47:256-260   DOI   PUBMED
43 Pontoriero R. Lindhe J, Nyman S, Karring T, Rosenberg E, Sanavi F. Guided tissue regeneration in the treatment of fur cation defects in mandibular molars. A clinical study of degree III involvements, J Clin Periodontol 1989: 16:170-174   DOI   PUBMED
44 Mallette WG. Quigley HJ. Adickes ED. Chitin in nature and technology. In: Muzzarelli RA. Jeuniaux C. Gooday GW eds. Chitosan Effect in Nature and Technology. New York: Pleum Press 1986; 435-442
45 Payot P. Bickel M. Cimasoni G. Longitudinal quantitative radiodensitometric study of treated and untreated lower molar furcation involvements. J Clin Periodontol 1987; 14: 8-18   DOI   PUBMED
46 Gottlow J. Guided tissue regeneration using bioresorbable and non-resorbable devices: initial healing and long-term results. J Periodontol 1993:64(11 Suppl) : 1157-65 Review   DOI   PUBMED   ScienceOn
47 Glickman I. Bifurcation involvement in periodontal disease. J Am Dent Assoc 1950:40: 528   PUBMED
48 Pangburn SH. Trescony PV, Heller J. Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. Biomaterials 1982: 3: 105-8   DOI   ScienceOn
49 Caffesse R. Smith BA, Duff B, Morrison EC, Merrill D, Becker W. Class II furcations treated by guided tissue regeneration in humans. Case reports. J Periodontol 1990:61:510-514   DOI   PUBMED
50 Caffesse RG, Dominguez LE, Nasjleti CE, Castelli WA, Morrison EC, Smith BA, Furcation defects in dogs treated guided tissue regeneration(GTR). J Periodontol 1990: 61: 45-50   DOI   PUBMED
51 Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 1982: 9: 290-296   DOI   PUBMED
52 Balassa LL, Prudden JF. Applications of chitin and chitosan in wound healing acceleration. In: Muzzarelli RA, Pariser ER eds. Proceedings of the 1st International Conference on Chitin and Chitosan. Cambridge, MA: MIT Press 1978
53 Vuddhakanok S, Solt CW, Mitchell JC, Foreman DW, Alger Fa. Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier In humans. J Periodontol 1993:64:202-210   DOI   PUBMED   ScienceOn
54 설양조, 김태일, 이재일, 배철민, 이승진, 정종평. 수종의 생분해성 차폐막의 생체친화도 및 조직재생유도 능력에 관한 실험적 연구. 대한치주과학회지 1995: 25: 603-613
55 Caffesse RG, Mota LF, Quinones CR. Morrison EC. Clinical comparison of resorbable and non-resorbable barriers for guided periodontal tissue regeneration. J Clin Periodontol 1997:24:747-752   DOI   ScienceOn
56 Waerhaug J. The fur cation problem. Etilogy, pathogenesis. diagnosis. therapy. and prognosis. J Clin Perodontol 1980: 7:73-95   DOI   PUBMED
57 신승윤, 박호남, 김경화, 이승진, 박윤정, 구영, 류인철, 한수부, 정종평. 키토산 나노 차폐막의 골조직 재생유도 능력에 관한 조직학적 연구. 대한치주과학회지 2004: 34: 543-9