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Antimicrobial effect of cefixime on 6 species of periodotopathogens  

Jang, Hyun-Seon (Dept. of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, Chosun University)
Park, Mun-Gyu (Dept. of Periodontology, College of Dentistry, Chosun University)
Kook, Joong-Ki (Dept. of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, Chosun University)
Kim, Hwa-Sook (Dept. of Oral Biochemistry, College of Dentistry, Chosun University)
Kim, Byung-Ock (Dept. of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, Chosun University)
Publication Information
Journal of Periodontal and Implant Science / v.35, no.2, 2005 , pp. 401-411 More about this Journal
Abstract
The aim of this study was to determine the minimal inhibitory concentration(MIC) of cefixime, which is a 3rd generation of cefalosporin, against 6 species of putative periodontopathogens; Fusobacterium nucleatum, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Prevotella nigrescens, Tannerella forsythia and Porphyromonas gingivalis. The efficacy of cefixime was examined by comparing it with that of several antibiotics(amoxicillin, $Augmentin^{(R)}$ ciprofloxacin, metronidazole, and tetracycline), which were used as the control. The MIC was measured using a microdilution method. The MIC of cefixime against the putative periodotopathogens, as a single use regimen, was relatively lower than that of the other antibiotics. The MIC of cefixime/metronidazole against P. intermedia ChDC KB14, P. nigrescens ChDC KB50, F. nucleatum ChDC PV-F37, F. nucleatum ChDC F130, and F. nucleatum ChDC F175, as a simultaneous regimen, was lower than that of the other antibiotics. The concentration of cefixime in the crevicular fluid of volunteers who received 250mg every 12 hours for 3 days was $9{\mu}g/ml$ after 9 hours. In conclusion, cefixime showed good antimicrobial activity in a single treatment or as a combined therapy with amoxicillin, $Augmentin^{(R)}$ or metronidazole against 6 periodontopathogens.
Keywords
Minimal inhibitory concentraion(MIC); cefixime;
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