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The Effects of Calcium-Phosphate Coated Xenogenic Bone and Type I Collagen for Bone Regeneration on the Calvarial Defects in Rabbits  

Kim, Chang-Han (Department of periodontology, College of Dentistry, Kyungpook National University)
Park, Jin-Woo (Department of periodontology, College of Dentistry, Kyungpook National University)
Lee, Jae-Mok (Department of periodontology, College of Dentistry, Kyungpook National University)
Suh, Jo-Young (Department of periodontology, College of Dentistry, Kyungpook National University)
Publication Information
Journal of Periodontal and Implant Science / v.34, no.1, 2004 , pp. 223-241 More about this Journal
Abstract
The purpose of this present study evaluated the osseous response around Ca-P coated xenogenic bone and compared osteogenic potential of Ca-P coated xenogenic bone to that of combination with type I collagen derived from bovine tendon as a biocompatible binder to prevent migration of bone particle on the repair of calvarial defects in rabbits. To study the effects of Ca-P coated xenogenic bone and collagen on bone healing, four 5-mm-diameter skull defect were made in calvaria with trephine filled with an autogenous bone chip or Ca-P coated xenogenic bone or Ca-P coated xenogenic bone and type I collagen (1:1 mixture by volume) or left empty. The defects were evaluated histologically at 1, 2, 4 and 8 weeks following implantation. Ca-P coated xenogenic bone at the calvarial defects of rabbits showed osteoconductivity at the margin of defect in the early stage of bony healing, but no direct contact with new bone was observed. With time passed by, it was resorbed slowly and showed consistent inflammatory reaction. An additional use of type I collagen derived from bovine tendon improved clinical handling, but no new bone formation was observed histologically. Above all, autogenous bone graft showed most prominent healing in quantity and density of new bone formation. According to this study, the use of Ca-P coated xenogenic bone alone and combination with type I collagen did not showed effective healing in quantity and density of new bone formation.
Keywords
Xenogenic bone; Type I collagen; Calcium-phosphate;
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1 Schallhorn RG, McClain PK. Combined osseous composite grafting, root conditioning, and guided tissue regeneration. Int J Periodontics Restorative Dent 1998;8(4):8-31
2 Cochran DL, Douglas HB. Augmentation of osseous tissue around nonsubmerged endosseous dental implants. Int J Periodontics Restorative Dent 1993;13:506-519   PUBMED
3 Aspenberg P, Kalebo P, Albrektsson T. Rapid bone healing delayed by bone matrix implantation. Int J Oral Maxillofac Implants 1998;3:123-127
4 Buck BE, Resnick L, Shah SM, Malinin TI. Human immunodeficiency virus cultured from bone. Implications for transplantation. Clin Orthop 1990;(251):249-53
5 Khavari F, Bajpai PK. Coralline-sulfate bone substitutes. Biomed Sci Instrum 1993;29:65-9   PUBMED
6 Gongloff RK, Montgomery CK. Experimental study of the use of collagen tubes for implantation of particulate hydroxylapatite. J Oral Maxillofac Surg 1985;43(11):845-9   DOI   ScienceOn
7 Shen K, Gongloff RK. Collagen tube containers: an effective means of controlling particulate hydroxyapatite implants. J Prosthet Dent 1986;56(1):65-70   DOI   ScienceOn
8 Schlegel AK, Donath K. BIO-OSS-a resorbable bone substitute? J Long Term Eff Med Implants 1998;8(3-4):201-9
9 DeLustro F, Dasch J, Keefe J, Ellingsworth L. Immune responses to allogeneic and xenogeneic implants of collagen and collagen derivatives. Clin Orthop 1990;(260):263-79
10 Levy P, Nevins A, LaPorta R. Healing potential of surgically-induced periodontal osseous defects in animals using mineralized collagen gel xenografts. J Periodontol 1981;52(6):303-6   DOI   PUBMED
11 Sela J, Applebaum J, Uretzky G. Osteogenesis induced by bone matrix is inhibited by inflammation. Biomater Med Devices Artif Organs 1986;14(3-4):227-37   DOI   PUBMED
12 Buser D, Bernard JP, Hofmann B, Lussi A, Mertler D, Schenk RK. Evaluation of bone filling materials in membrane-protected defects of the mandible. A histomorphometric study in miniature pigs. Clinical Oral Implants Research 1998;9:137-150   DOI   ScienceOn
13 Harvey WK, Pincock JL, Matukas VJ, Lemons JE. Evaluation of a subcutaneously implanted hydroxylapatite-avitene mixture in rabbits. J Oral Maxillofac Surg 1985;43(4):277-80   DOI   ScienceOn
14 Skoglund A, Hising P, and Young C. A clinical and histologic examination in humans of the osseous response to implanted natural bone mineral. Int J Oral Maxillofac Implants 1997;12:194-199   PUBMED
15 Cortellini P, Bowers GM. Periodontal regeneration of intrabony defects an evidence based treatment approach. Int J Periodontics Restorative Dent 1995;15(2):128-45.11
16 Urist MR, Silverman BF, Buring K, Dubuc FL, Rosenberg JM. The bone induction principle. Clin Orthop 1967;53:243-83
17 Brunsvold MA, Mellonig JT. Bone grafts and periodontal regeneration. Periodontol 2000 1993;1:80-91   DOI   ScienceOn
18 Jensen SS, Aaboe M, Pinholt EM, Hjorting-Hansen E, Melsen F, Ruyter IE. Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants 1996;11(1):55-66   PUBMED
19 Urist MR. Bone formation by autoinduction. Science 1965;150(698):893-9   DOI   PUBMED   ScienceOn
20 Shanaman RH. A retrospective study of 237 sites treated consecutively with guided tissue regeneration. Int J Periodontics Restorative Dent 1994;14(4):292-301   PUBMED
21 Spira M, Liu B, Xu Z. et al. Human amnion collagen for soft tissue augmentation-biomechanical characterizations and animal observations. J Biomed Mater Res 1994;28:91-96   DOI   ScienceOn
22 Gogolewski S, Jovanovic M, Perren SM, Dillon JG, Hughes MK. Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly (3-hydroxybutyrate) (PHB), andpoly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). J Biomed Mater Res 1993;27(9):1135-48   DOI   ScienceOn
23 Doillon CJ, Whyne CF, Brandwein S, Silver FH. Collagen-based wound dressings: control of the pore structure and morphology. J Biomed Mater Res 1986;20(8):1219-28   DOI   PUBMED
24 Tsai CH, Chou MY, Jonas M, Tien YT, Chi EY. A composite graft material containing bone particles and collagen in osteoinduction in mouse. J Biomed Mater Res 2002;63(1):65-70   DOI   ScienceOn
25 Boyne PJ. Induction of bone repair by various bone grafting materials. Hard tissue growth, repair and remineralization. Ciba Foundation Symposium 1973;11:121-141
26 Libin BM, Ward HL, Fishman L. Decalcified, lyophilized bone allografts for use in human periodontal defects. J Periodontol 1975;46(1):51-6   DOI   PUBMED
27 Dodde R, Yavuzer R, Bier UC, Alkadri A, Jackson IT. Spontaneous bone healing in the rabbit. J Craniofac Surg 2000;11(4):346-9   DOI   ScienceOn
28 Thaller SR, Kim S, Tesluk H, Kawamoto H. The split calvarial bone graft donor site: the effects of surgical and hydroxyapatite impregnated with collagen. Ann Plast Surg 1990;25(6):435-9   DOI   ScienceOn
29 Becker W, Schenk R, Higuchi K, Lekholm U, Becker BE. Variations in bone regeneration adjacent to implants augmented with barrier membranes alone, or with demineralized freeze-dried bone or autologous grafts: A study in dogs. Int J Oral Maxillofac Implants 1995;10:143-154   PUBMED
30 Ripamonti U, Schnitzler CM, Cleaton-Jones PC. Bone induction in a composite allogeneic bone/alloplastic implant. J Oral Maxillofac Surg 1989;47(9):963-9   DOI   ScienceOn
31 Bell R, Beirne OR. Effect of hydroxylapatite, tricalcium phosphate, and collagen on the healing of defects in the rat mandible. J Oral Maxillofac Surg 1988l;46(7):589-94   DOI   ScienceOn
32 Pinholt EM, Haanaes HR, Roervik M, Donath K, Bang G. Alveolar ridge augmentation by osteoinductive materials in goats. Scand J Dent Res 1992;100(6):361-5   PUBMED
33 Smiler DG, Johnson PW, Lozada JL, Misch C, Rosenlicht JL, Tatum OH Jr, Wagner JR. Sinus lift grafts and endosseous implants. Treatment of the atrophic posterior maxilla. Dent Clin North Am 1992;36(1):151-86   PUBMED
34 Cho. JS, Kim Jy, Chung CH, Yim SB. The comparison of the effects on the regeneration with xenografts on the furcation involvement in beagle dogs. The Journal of Korean Academy of Periodontology 2000;30:277-286
35 Uretzky G, Appelbaum J, Sela J. Inhibition of the inductive activity of demineralized bone matrix by different percutaneous implants. Biomaterials 1988;9(2):195-7   DOI   ScienceOn
36 Quintero G, Mellonig JT, Gambill VM, Pelleu GB Jr. A six-month clinical evaluation of decalcified freeze-dried bone allografts in periodontal osseous defects. J Periodontol 1982;53(12):726-30   DOI   PUBMED
37 Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects. Int J Periodontics Restorative Dent 1984;4(6):40-55   PUBMED
38 Becker W, Lynch SE, Lekholm U, Becker BE, Caffesse R, Donath K, Sanchez R. A comparison of ePTFE membranes alone or in combination with platelet-derived growth factors and insulin-like growth factor-I or demineralized freeze-dried bone in promoting bone formation around immediate extraction socket implants. J Periodontol 1992;63(11):929-40   DOI   PUBMED
39 Park TS, Lim SB, Chung CH, Kim JY. Histologic study on the effect of two types of bovine bone powder in extraction socket of beagle dogs. The Journal of Korean Academy of Periodontology 2000;30:527-538   DOI
40 Nathan RM, Bentz H, Armstrong RM, Piez KA, Smestad TL, Ellingsworth LR, McPherson JM, Seyedin SM. Osteogenesis in rats with an inductive bovine composite. J Orthop Res 1988;6(3):324-34   DOI   PUBMED
41 Blumenthal NM, Alves ME. The use of demineralized freeze-dried bone-glycoprotein matrix grafts in treating baboon periodontal infrabony defects. Int J Periodontics Restorative Dent 2000;20(1):61-9   PUBMED
42 Klinge B, Alberius P, Isaksson S, Jonsson J. Osseous response to implanted natural bone mineral and synthetic hydroxylapatite ceramic in the repair of experimental skull bone defects. J Oral Maxillofac Surg 1992;50(3):241-9   DOI   ScienceOn
43 Bucholz RW, Carlton A, Holmes RE. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop Clin North Am 1987;18(2):323-34   PUBMED
44 Froum SJ, Weinberg MA, Tarnow D. Comparison of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal defects. A clinical study. J Periodontol 1998;69(6):698-709   DOI   PUBMED   ScienceOn
45 Slotte C, Lundgren D. Augmentation of calvarial tissue using non-permeable silicone domes and bovine bone mineral. An experimental study in the rat. Clin Oral Implants Res 1999;10(6):468-76   DOI   ScienceOn
46 Burchadt H. The biology of bone graft repair. Clinical Orthopaedics and Related Research 1983;174:28-42
47 Mellonig JT, Triplett RG. Guided tissue regeneration and endosseous dental implants. Int J Periodontics Restorative Dent 1993;13(2):108-19   PUBMED
48 Frame, J. W. A convenient animal model for testing bone substitute materials. J Oral Surg 1980;38:176
49 Matui R, Okura N, Osaki KI. et al. histological evaluation of skin reconstruction using artificial dermis. Biomaterials 1996;17: 995-1000   DOI   ScienceOn
50 Becker W, Urist MR, Tucker LM, Becker BE, Ochsenbein C. Human demineralized freeze-dried bone: Inadequate induced bone formation in athymic mice. A preliminary report. J Periodontol 1995;66:822-828   DOI   PUBMED   ScienceOn
51 Minabe M, Kodama T, Kogou T, Tamura T, Hori T, Watanabe Y, Miyata T. Different cross-linked types of collagen implanted in rat palatal gingiva. J Periodontol 1989;60(1):35-43   DOI   PUBMED
52 Schendel S, Bresnick S, Cholon A. Preliminary report: a ceramic containing crosslinked collagen as a new cranial onlay and inlay material. Ann Plast Surg 1997;38(2):158-62   DOI   PUBMED   ScienceOn
53 Denissen HW, De Groot K, Makkes PC, Van den Hoof A, Klopper PJ. Tissue response to dense apatite implants in rats. J Biomed Mater Res 1980;14:713-721   DOI   ScienceOn
54 Cohen RE, Mullarky RH, Noble B, Comeau RL, Neiders ME. Phenotypic characterization of mononuclear cells following anorganic bovine bone implantation in rats. J Periodontol 1994;65(11):1008-15   DOI   PUBMED   ScienceOn
55 Hurzeler MB, Kirsch A, Ackermann KL, Quinones CR. Reconstruction of the severely resorbed maxilla with dental implants in the augmented maxillary sinus: a 5-year clinical investigation. Int J Oral Maxillofac Implants 1996;11(4):466-75   PUBMED