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GCF concentration and minimal inhibitory concentration of cefuroxime axetil against periodontopathogens  

Jang, Hyun-Seon (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
Kim, Jae-Duk (Department of Periodontology, College of Dentistry, Chosun University)
Kook, Joong-Ki (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
Kim, Hwa-Sook (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
You, So-Young (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
Kim, Mi-Kwang (Department of Oral Biochemistry, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
Kim, Byung-Ock (Department of Periodontology, College of Dentistry, Chosun University, Oral Biology Research Institute, College of Dentistry, Chosun University)
Publication Information
Journal of Periodontal and Implant Science / v.33, no.3, 2003 , pp. 341-348 More about this Journal
Abstract
The purpose of this study was to determine the minimal inhibitory concentration (MIC) of cefuroxime axetil,　semisynthetic cefalosporin, for some putative periodotopathogens; F. nucleatum, A. actinomycetemcomitans P. intermedia and P. gingivalis. To investigate the efficacy of cefuroxime axetil, several antibiotics, amoxicillin, metronidazole, and ciprofoxacine, were used as control. The MIC was measured by Murray' s method. The MIC of cefuroxime axetil against some putative microbes, as a single use regimen, was relatively high in comparison with that of the other antibiotics used in this study. The MIC of cefuroxime axetil/metronidazole against some putative microbes, as a simultaneous regimen, was similar to that of the other antibiotics used in this study. The manimal level of cefuroxime concentration in gingival fluid was 9${\mu}$/ml at 36hr after the first dose. In conclusion, within the limited experiment, metronidazole/ cefuroxime axetil therapy of periodontitis may provide a therapeutic benefits in reducing the periodontopathogens.
Keywords
Cefuroxime axetil; Minimal inhibitory concentraion(MIC); Gingival crevicular fluid(GCF);
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