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Clinical use of Platelet Rich Fibrin(PRF) in Various Hard and Soft Tissue Defect : Case Report  

Chee, Young-Deok (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University)
Go, Seo-Wook (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University)
Publication Information
Journal of Dental Rehabilitation and Applied Science / v.23, no.4, 2007 , pp. 303-312 More about this Journal
Abstract
Recently several studies have been developed not only to apply bone materials to bony defect, but also to use osteogenic and osteoinductive materials to form bone more effectively. In 1998 Mark et al applied gel formation of PRP(platelet-rich plasma) in bony transplantation for mandibular reconstruction as one of the method of stimulating bone formation in maxillofacial area, which is contain of varies growth factors. After he reported that PRP accelerate bone formation, which is used in varies bone transplantation and augmentation with a good result. Especially there are amount of growth factors in PRP, and PRP increase angiogenesis, cell division, and mesenchymal cell growth. Moreover it is capable of osteoconduction, hemostatitis, anti-infection, forming the shape at transplantation, ease of handling, and recipient site stability. So it is known that success rate is high in bone transplantation. However PRP need tissue adhesive to make plasma to solid form. Thrombin and calcium chloride, component of PRP, is extracted from autogenic donor. So it is expensive to extract and there is possibility of hepatitis, AIDS, and hematogenous metastasis. After all, tissue adhesive have the limitation and danger of use. So we are willing to introduce that we had get some idea after using PRF(platelet-rich fibrin) in the various hard and soft tissue bony defect, which is self extracted simply and contain growth factors.
Keywords
Bone agumentation; Dental Implant; PRF;
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1 Marx RE, Carlson ER, Eichstaedt RM et al: Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Moo Oral pathol 85:836, 1998
2 Sonnleiter D: A simplified technique for producing platelet -rich plasma and platelet concentrate for intraoral bone grafting techniques : a technical note. Int J Oral Maxillofacial implant 15: 879, 2000
3 Choukroun J, Diss A et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e56, 2006   DOI   ScienceOn
4 Whitman DH, Berry RL, Green DM: Platelet Gel: An anutologous alternative to fibrin glue with applications, in oral and maxillofacial surgery. J Oral and maxillofac Surg 55: 1294, 1997
5 Atwood DA, Coy WA: Clinical cephalometric and densitometric study of reduction residual ridges J Prosthet Dent 26: 280, 1971
6 Dohan DM, Choukroun J et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet -related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e45. 2006   DOI   ScienceOn
7 Tayapongsak P: Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofacial Surg. 52: 161, 1994
8 Caisson GE, Bergman B, Hedegard B : Changes in contour of the maxillary alveolar process under immediate denture. Acta Odontol Scan 25: 45, 1967
9 Dohan DM, Choukroun J et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e37,2006   DOI   ScienceOn
10 Ross R, Raines EW, Bowen-Pope DF. The biologu of platelet-derived growth factor. Cell. 467:155, 1986
11 Canalis E, McCarthy TL, Centrella M. : The role of growth factors in skeletal remodeling. Entocrinol Meta Cl: North Am. 18: 903, 1989
12 Dohan DM, Choukroun J et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e51,2006   DOI   ScienceOn
13 Choukroun J, Diss A et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Moo Oral Pathol Oral Radiol Endod 101:299,2006   DOI   ScienceOn
14 Dohan DM, Choukroun J. PRP, cPRP, PRF, PRG, PRGF, FC . . .how to find your way in the jungle of platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:305, 2007   DOI   ScienceOn
15 JW Shin. : An experimental study on healing effect of the PDGF treated allogeneic demineralized freeze-dried bone transplanted in the calvarial defect of the rat. J Kor Oral Maxillofac Plast Recon Surg. 22: 614, 2000
16 Landesberg R: Quantification of growth factors levels using a simplified method of platelet-rich plasma gel preparation. J Oral Maxillofacial Surg. 58: 297, 2000
17 Atwood DA: Reduction of residual ridges: A major oral disease entity, J Prosthet Dent 26: 266, 1971
18 Choukroun J, Adda F, Schoeffler C, Vervelle A. Vne opportunit? en paro-implantologie: le PRF. Implantodontie 42:55.2001