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http://dx.doi.org/10.5851/kosfa.2022.e46

Review of the Current Research on Fetal Bovine Serum and the Development of Cultured Meat  

Lee, Da Young (Department of Animal Science and Technology, Chung-Ang University)
Lee, Seung Yun (Department of Animal Science and Technology, Chung-Ang University)
Yun, Seung Hyeon (Department of Animal Science and Technology, Chung-Ang University)
Jeong, Jae Won (Department of Animal Science and Technology, Chung-Ang University)
Kim, Jae Hyeon (Department of Animal Science and Technology, Chung-Ang University)
Kim, Hyun Woo (Department of Animal Science and Technology, Chung-Ang University)
Choi, Jung Seok (Department of Animal Science, Chungbuk National University)
Kim, Gap-Don (Graduate School of International Agricultural Technology, Institutes of Green Bio Science and Technology, Seoul National University)
Joo, Seon Tea (Division of Applied Life Science (BK21 Four), Institute of Agriculture & Life Science, Gyeongsang National University)
Choi, Inho (Department of Medical Biotechnology, Yeungnam University)
Hur, Sun Jin (Department of Animal Science and Technology, Chung-Ang University)
Publication Information
Food Science of Animal Resources / v.42, no.5, 2022 , pp. 775-799 More about this Journal
Abstract
The purpose of this review is to summarize studies that investigate blood and the main components of fetal bovine serum (FBS) in vertebrates, including major livestock, and review the current research on commercializing cultured meat. Detailed research on FBS is still lacking; however, some studies have shown that FBS consists of proteins, carbohydrates, growth factors, cytokines, fats, vitamins, minerals, hormones, non-protein nitrogen, and inorganic compounds. However, there are few studies on how the composition of FBS differs from blood or serum composition in adult animals, which is probably one of the main reasons for not successfully replacing FBS. Moreover, recent studies on the development of FBS replacers and serum-free media have shown that it is difficult to conclude whether FBS has been completely replaced or serum-free media have been developed successfully. Our review of the industrialization of cultured meat reveals that many basic studies on the development of cultured meat have been conducted, but it is assumed that the study to reduce or replace ingredients derived from fetuses such as FBS has not yet been actively developed. Therefore, developing inexpensive and edible media is necessary for the successful industrialization of cultured meat.
Keywords
cultured meat; fetal bovine serum; blood; muscle cells; scaffolds;
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