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http://dx.doi.org/10.5851/kosfa.2016.36.2.170

Anti-diabetic Effect of Fermented Milk Containing Conjugated Linoleic Acid on Type II Diabetes Mellitus  

Song, Kibbeum (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Song, In-Bong (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Gu, Hye-Jung (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Na, Ji-Young (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Kim, Sokho (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Yang, Hee-Sun (R&D Planning Department, Imsil Research Institute of Cheese Science)
Lee, Sang-Cheon (R&D Planning Department, Imsil Research Institute of Cheese Science)
Huh, Chang-Ki (R&D Planning Department, Imsil Research Institute of Cheese Science)
Kwon, Jungkee (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University)
Publication Information
Food Science of Animal Resources / v.36, no.2, 2016 , pp. 170-177 More about this Journal
Abstract
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has been reported to be able to reduce body fat. In this study, we investigated the antidiabetic effect of fermented milk (FM) containing CLA on type II diabetes db/db mice. Mice were treated with 0.2% low FM, 0.6% high FM, or Glimepiride (GLM) for 6 wk. Our results revealed that the body weight and the levels of fasting blood glucose, serum insulin, and leptin were significantly decreased in FM fed mice compared to db/db mice. Oral glucose tolerance and insulin tolerance were significantly ameliorated in FM fed mice compared to db/db mice. Consistent with these results, the concentrations of serum total cholesterol, triglycerides, and LDL cholesterol were also significantly decreased in FM fed mice compared to db/db mice. However, the concentration of HDL cholesterol was significantly higher in FM fed mice compared to db/db mice. These results were similar to those of GLM, a commercial anti-diabetic drug. Therefore, our results suggest that FM has anti-diabetic effect as a functional food to treat type II diabetes mellitus.
Keywords
fermented milk; conjugated linolic acid; diabetes mellitus; db/db mice; insulin;
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