[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5851/kosfa.2015.35.6.831

Bioactive Peptides in Milk and Dairy Products: A Review

Park, Young Woo (Georgia Small Ruminant Research & Extension Center, Fort Valley State University, Department of Food Science & Technology, University of Georgia)
Nam, Myoung Soo (Department of Animal Bio-system Science, College of Agriculture and Life Sciences, Chungnam National University)

Publication Information

Food Science of Animal Resources / v.35, no.6, 2015 , pp. 831-840 More about this Journal

Abstract

Functionally and physiologically active peptides are produced from several food proteins during gastrointestinal digestion and fermentation of food materials with lactic acid bacteria. Once bioactive peptides (BPs) are liberated, they exhibit a wide variety of physiological functions in the human body such as gastrointestinal, cardiovascular, immune, endocrine, and nervous systems. These functionalities of the peptides in human health and physiology include antihypertensive, antimicrobial, antioxidative, antithrombotic, opioid, anti-appetizing, immunomodulatory and mineral-binding activities.

Keywords

bioactive peptide; milk; proteins; functional foods; human health;

Citations & Related Records

Reference

1	Petrillo, Jr. E. W. and Ondetti, M. A. (1982) Angiotensin converting enzyme inhibitors: Medicinal chemistry and biological actions. Med. Res. Rev. 2, 1-41. DOI
2	Rival, S. G., Boeriu, C. G., and Wichers, H. J. (2001) Caseins and casein hydrolysates. 2. Antioxidativeproperties and relevance to lipoxygenase inhibition. J. Agr. Food Chem. 4, 295-302.
3	Playne, M. J., Bennett, L. E., and Smithers, G. W. (2003) Functional dairy foods and ingredients. Australian J. Dairy Technol. 58, 242-264.
4	Qian, Z. Y., Jolles, P., Migliore-Samour, D., Schoentgen, F., and Fiat, A. M. (1995). Sheep kappa-casein peptides inhibit platelet aggregation. Biochim Biophys Acta 1244, 411-417. DOI
5	Regester, G. O., Smithers, G. W., Mitchell, I. R., McIntosh, G. H., and Dionysius, D. A. (1997) Bioactive factors in milk: Natural and induced. In: Milk composition, production and biotechnology. Welch, R., Burns, D., Davis, S. Popay, A., and Prosser, C. (ed) CAB International. pp. 119-132.
6	Rokka, T., Syvoja, E. L, Tuominen, J., and Korhonen, H. (1997) Release of bioactive peptides by enzymatic proteolysis of Lactobacillus GG fermented UHT milk. Milchwissenschaft 52, 675-678.
7	Roy, M. K., Watanabe, Y., and Tamai, Y. (1999) Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J. Biosci. Bioeng. 88, 426-432. DOI
8	Schanbacher, F. L., Talhouk, R. S., Murray, F. A., Gherman, L. I., and Willet, L. B. (1998) Milk-born bioactive peptides. Int. Dairy J. 8, 393-403. DOI
9	Meisel, H. and Olieman, C. (1998) Estimation of calcium-binding constants of casein phosphopeptides by capillary zone electrophoresis. Analytica Chimica Acta 372, 291-297. DOI
10	Park, Y. W. (1990) Nutrient profiles of commercial goat milk cheeses manufactured in the United States. J. Dairy Sci. 73, 3059-3067. DOI
11	Meisel, H. and Schlimme, E. (1994) Inhibitors of angiotensin-converting enzyme derived from bovine casein (casokinins). In: Brantl, V., Teschemacher, H., editors, κ-casomorphins and related peptides: recent developments. Weinheim: VCH. pp. 27-33.
12	Meisel, H. and Schlimme, E. (1996) Bioacive peptides derived from milk proteins: ingredients for functional foods. Kieler Milchwirtschaftliche Forschungsberichte 48, 343-357.
13	Nagaoka, S., Futamura, Y., Miwa, K., Takako, A., Yamauchi, K., Kanamaru, Y., Tadashi, K., and Kuwata, T. (2001) Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem. Biophys Res. Commun. 281, 11-17. DOI
14	Park, Y. W. (2006) Goat milk - Chemistry and Nutrition. In: Handbook of Milk of Non-Bovine Mammals. Y. W. Park and G. F. W. Haenlein, (ed) Blackwell Publishers. Ames, Iowa and Oxford, England. pp. 34-58.
15	Park, Y. W. (2009a) Bioactive components of goat milk. In: Bioactive Components in Milk and Dairy Products. Y. W. Park, (ed) Wiley-Blackwell Publishers, Ames, Iowa and Oxford, England. pp. 43-82.
16	Park, Y. W. (2009b) Overview of bioactive components in milk and dairy products. In: Bioactive Components in Milk and Dairy Products. Park, Y. W. (ed) Wiley-Blackwell Publishers, Ames, Iowa and Oxford, England. pp. 3-14.
17	Korhonen, H. and Pihlanto-Leppala, A. (2004) Milk-derived bioactive peptides: Formation and prospects for health promotion. In: Handbook of functional dairy products. Shortt, C. and O’Brien, J. (ed) CRC Press, Boca Raton, F. L., USA. pp. 109-124.
18	Jolles, P., Levy-Toledano, S., Fiat, A. M., Soria, C., Gillesen, D., Thomaidis, A., Dunn, F. W., and Caen, J. (1986) Analogy between fibrinogen and casein: effect of an undecapeptide isolated from k-casein on platelet function. Eur. J. Biochem. 158, 379-382. DOI
19	Kitts, D. D. and Weiler, K. (2003) Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr. Pharm. Des. 9, 1309-1323. DOI
20	Iwami, K., Sakakibara, K., and Ibuki, F. (1986) Involvement of post-digestion hydrophobic peptides in plasma cholesterol-lowering effect of dietary plant protein. Agri. Bio. Chem. 50, 1217-1222. DOI
21	Jones, F. S. and Simms, H. S. (1930) The bacterial growth inhibitor (lactenin) of milk. J. Exp. Med. 51, 327-339. DOI
22	Korhonen, H. and Marnila, P. (2006) Bovine milk antibodies for protection against microbial human diseases. In: Nutraceutical Proteins and Peptides in Health and Disease. Mine, Y. and Shahidi, S. (ed) Taylor & Francis Group, Boca Raton, F. L., USA. pp. 137-159.
23	Korhonen, H. and Pihlanto-Leppala, A. (2004) Milk-derived bioactive peptides: formation and prospects for health promotion. In: Handbook of Functional Dairy Products. C. Shortt and J. O’Brien eds. CRC Press. Boca Raton, F. L., USA. pp. 109-124.
24	Korhonen, H., Pihlanto-Leppala, A., Rantamaki, P., and Tupasela, T. (1998) The functional and biological properties of whey proteins: prospects for the development of functional foods. Agri. Food Sci. Finland 7, 283-296.
25	Gill, H. S., Coull, F., Rutherfurd, K. J., and Cross, M. L. (2000) Immunoregulatory peptides in bovine milk. Br. J. Nutr. 84, S111-S117.
26	Grosvenor, C. E., Picciano, M. F., and Baumrucker, C. R. (1992) Hormones and growth factors in milk. Endocr. Rev. 14, 710-728.
27	Calder, P. C. (1994) Glutamine and the immune system. Clin. Nutr. 13, 2-8.
28	Bezkorovainy, A. and Topouzian, N. (1981) Bifidobacteriumbifidus var. Pennsylvanicus growth promoting activity of human milk casein and its derivatives. Int. J. Biochem. 13, 585-590. DOI
29	Bounous, G. and Gold, P. (1991) The biological activity of undenatured dietary whey proteins: Role of glutathione. Clin. Invest. Med. 14, 296-309.
30	Byun, H.-G., Lee, J. K., Park, H. G., Jeon, J.-K., and Kim, S.-K. (2009) Antioxidant peptides isolated from the marine rotifer, Brachionus rotundiformis. Process Biochem. 44, 842-846. DOI
31	Chabance, B., Marteau, P., Rambaud, J. C., Migliore-Samour, D., Jolles, P., Boynard, M., Perrotin, P., Buillet, R., and Fiat, A. M. (1998) Casein peptided release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 80, 155-165. DOI
32	Matar, C., LeBlanc, J. G., Martin, L., and Perdigon, G. (2003) Active peptides released in fermented milk: role and functions. Handbook of Fermented Functional Foods. Functional Foods and Nutraceuticals series. In: Farnworth ER, (ed) CRC Press. Boca Raton, F. L., USA, pp. 177-201.
33	Meisel, H. (1998) Overview on milk protein-derived peptides. Inter. Dairy J. 8, 363-373. DOI
34	Krissansen, G. W. (2007) Emerging health properties of whey proteins and their clinical implications. J. Amer. College Nutr. 26, 713S-723S. DOI
35	Li, G., Le, G., Shi, Y., and Shrestha, S. (2004) Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr. Res. 24, 469-486. DOI
36	Meisel, H. and FitzGerald, R. J. (2000) Opioid peptides encrypted in intact milk protein sequences. Br. J. Nutr. 84, 27-31.
37	Meisel, H. and FitzGerald, R. J. (2003) Biofunctional peptides From milk proteins: mineral binding andcytomodulatory effects. Curr. Pharm. Des. 9, 1289-1295. DOI
38	Korhonen, H. and Pihlanto, A. (2007a) Food-derived bioactive peptides - opportunities for designing future foods. Curr. Pharm. Des. 9, 1297-1308.
39	Korhonen, H. and Pihlanto, A. (2007b) Bioactive peptides from food proteins. In: Handbook of food products manufacturing. Hui, Y. H. (ed) John Wiley & Sons, Inc., pp. 5-37.
40	Hill, R. D., Lahov, E., and Givol, D. (1974) A rennin-sensitive bond in alpha and beta casein. J. Dairy Res. 41, 147-153. DOI
41	Hutchens, T. W., Rumball, S. V., and Lonnerdal, B. (1994) Lactoferrin: structure and function. Adv. Exp. Med. Biol. 357, 1-298. DOI
42	Gyorgy, P., Jeanloz, R. W., Von Nicolai, H., and Zilliken, F. (1974) Undialyzable growth factors for Lactobacillus bifidus var. Pennsylvanicus. Eur. J. Biochem. 43, 29-33. DOI
43	Gobbetti, M., Minervini, F., and Rizzello, C. G. (2004) Angiotensin I-converting enzyme inhibitory and antimicrobial bioactive peptides. Int. J. Dairy Technol. 57, 173-188. DOI
44	Gobbetti, M., Minervini, F., and Rizzello, C. G. (2007) Bioactive peptides in dairy products. In: Handbook of food products manufacturing. Y. H. Hui, (ed), John Wiley & Sons, Inc. pp. 489-517.
45	Goldman, A. S. and Goldblum, R. M. (1995) Defense agents in milk: A defense agents in human milk. In: Handbook of Milk Composition. Jensen, R. (ed) Academic Press, NY, pp. 727-748.
46	Haenlein, G. F. W. and Caccese, R. (1984) Goat milk versus cow milk. In: Extension Goat Handbook. Haenlein, G. F. W. and Ace, D. L. (ed) USDA Publication, Washington, D.C., E-1: pp. 1-4.
47	Hartmann, R., Gunther, S., Martin, D., Meisel, H., Pentzien, A. K., Schlimme, E., and Scholz. N. (2000) Cytochemical model systems for the detection and characterization of potentially bioactive milk components. Kieler Milchwirtschaftliche Forschungsberichte 52, 61-85.
48	Hartmann, R. and Meisel, H. (2007) Food-derivedpeptides with biological activity: from research to food applications. Curr. Opin. Biotech. 18, 1-7. DOI
49	Clare, D. A., Catignani, G. L., and Swaisgood, H. E. (2003) Biodefense properties of milk: the role of antimicrobial proteins and peptides. Curr. Pharm. Des. 9, 1239-1255. DOI
50	Elitsur, Y. and Luk, G. D. (1991) β-casomorphin (BCM) and human colonic lamina proprialymphocyte proliferation. Clin. Exp. Immunol. 85, 493-497.
51	Fiat, A. M., Miglilore-Samour, D., Jolles, P., Crouet, L., Collier, C., and Caen, J. (1993) Biologicallyactive peptides from milk proteins with emphasis on two example concerning antithrombotic and immuno-modulating activities. J. Dairy Sci. 76, 301-310. DOI
52	Clare, D. A. and Swaisgood, H. E. (2000) Bioactive milk peptides: A prospectus. J. Dairy Sci. 83, 1187-1195. DOI
53	Denhard, M., Claus, R., Munz, O., and Weiler, U. (2000) Course of epidermal growth factor (EGF) and insulin-like growth factor (IFG-I) in mammary secretions of the goat during endpregnancy and early lactation. J. Vet. Med. Ser. A 47, 533-540. DOI
54	Eliassen, L. T., Berge, G., Sveinbjornsson, B., Svendsen, J. S., Vorland, L. H., and Rekdal, O. (2002) Evidence for a direct antitumor mechanism of action of Bovine lactoferricin. Anticancer Res. 22, 2703-2710.
55	FitzGerald, R. J. and Meisel, H. (2000) Milk protein derived peptide inhibitors of angiotensin-I converting enzyme. Brit. J. Nutr. 84, S33-S37.
56	FitzGerald R. J. and Meisel, H. (2003) Milk protein hydrolysates and bioactive peptides. In: Advances in Dairy Chemistry. Fox, P. F. and McSweeney, P. L. H. 3rd ed, Kluwer Academic/Plenum Publishers, NY, pp. 675-698.
57	FitzGerald, R. J., Murray, B. A., and Walsh, D. J. (2004) Hypotensive peptides from milk proteins. J. Nutr. 134, 980S-988S.
58	Brown, K. D. and Blakeley, D. M. (1984) Partial purification and characterization of a growth factor present in goat’s colostrum. Biochem. J. 219, 609-617. DOI
59	Bezkorovainy, A., Grohlich, D., and Nichols, J. H. (1979) Isolation of a glycopeptide fraction with Lactobacillus bifidus subspecies Pennsylvanicus growth-promoting activity from whole human milk casein. Am. J. Clin. Nutr. 32, 1428-1432.
60	Yoshikawa, M., Sasaki, R., and Chiba, H. (1981) Effect of chemical phosphorylation of bovine casein components on the properties related to casein micelle formation. Agr. Bio. Chem. 45, 909-914. DOI
61	Zhang, X. and Beynen, A. (1993) Lowering effect of dietary milk-whey protein v. casein on plasmaand liver cholesterol concentrations in rats. Brit. J. Nutr. 70, 139-146. DOI
62	Stoeck, M., Ruegg, C., Miescher, S., Carrel, S., Cox, D., Von Fliedner, V., and Alkan, S. (1989) Comparison of the immunosuppressive properties of milk growth factor and transforming growth factors beta 1 and beta 2. J. Immunol. 143, 3258-3265.
63	Théolier, J., Fliss, I., Jean, J., and Hammami, R. (2013). Milk AMP: a comprehensive database of antimicrobial peptides of dairy origin. Dairy Sci. Technol. 94, 181-193.
64	Suetsuna, R., Ukeda, H., and Ochi, H. (2000) Isolation and characterization of free radical scavenging activities peptides derived from casein. J. Nutr. Biochem. 11, 128-131. DOI
65	Wakabayashi, H., Takase, M., and Tomita, M. (2003) Lactoferricin derived from milk proteinlactoferrin. Curr. Pharm. Des. 9, 1277-1287. DOI
66	Tani F., Shiiota A., Chiba H., and Yoshikawa M. (1994) Saerorphin, and opioid peptide derived from bovine serum albumin. In: β-Casomorphins and Related Peptides: Recent Developments. V. Brandtl and H. Teschemacher, (ed) Weinheim: VCH, Germany.
67	Viljoen, M. (1995) Lactoferrin: a general review. Haematologica 80, 252-267.
68	Wilson, Md. and Rudel, L. L. (1994) Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J. Lipid Res. 35, 943-955.
69	Wu, F. Y. and Elsasser, T. H. (1995) Studies on cell growth promoting activity in goat milk. J. Chinese Agric. Chem. Soc. 33, 326-332.
70	Schlimme, E. and Meisel, H. (1995) Bioactive peptides derived from milk proteins. Structural, physiological, and analytical aspects. Die Nahrung 39, 1-20. DOI
71	Shah, N. P. (2000) Effects of milk-derived bioactives: an overview. Brit. J. Nutr. 84, S3-S10.
72	Park, Y. W., Juárez, M., Ramos, M., and Haenlein, G. F. W. (2007). Physicochemical characteristics of goat and sheep milk. Special Issue book on Goat milk and Sheep milk. Small Ruminant Res. J. 68, 88-113. DOI

Reference

	Karna Ramachandraiah. (2017) Innovative Food Science & Emerging Technologies Characterization of soy protein hydrolysates produced by varying subcritical water processing temperature / 43 , 201
9	Gavino Faa. (2016) Expert Review of Proteomics Proteomics applied to pediatric medicine: opportunities and challenges / 13 (9) , 883
	Sonya Mros. (2017) Small Ruminant Research Comparison of the bioactivity of whole and skimmed digested sheep milk with that of digested goat and cow milk in functional cell culture assays / 149 , 202
	Yixian Quah. (2018) International Journal of Peptide Research and Therapeutics Identification of Novel Cytotoxic Peptide KENPVLSLVNGMF from Marine Sponge Xestospongia testudinaria, with Characterization of Stability in Human Serum /
3	Massimo Lucarini. (2017) Beverages Bioactive Peptides in Milk: From Encrypted Sequences to Nutraceutical Aspects / 3 (3) , 41
3	V. B. Kulyk. (2016) Neurophysiology Mechanisms of Expression and Release of Endogenous Opioids in Peripheral Tissues / 48 (3) , 205
7	R. M. Bruckmaier. (2017) Animal Production Science Lactational challenges in transition dairy cows / 57 (7) , 1471
	Aline Reyes-Díaz. (2017) International Journal of Dairy Technology Immunomodulation by hydrolysates and peptides derived from milk proteins /
	Ruann Janser Soares de Castro. (2017) Food Structure Whey protein as a key component in food systems: Physicochemical properties, production technologies and applications /
	L.P. Cappato. (2017) Trends in Food Science & Technology Ohmic heating in dairy processing: Relevant aspects for safety and quality / 62 , 104
9	R. Tacoma. (2017) Journal of Dairy Science Ratio of dietary rumen degradable protein to rumen undegradable protein affects nitrogen partitioning but does not affect the bovine milk proteome produced by mid-lactation Holstein dairy cows / 100 (9) , 7246
	Dominic Agyei. (2017) Analytical and Bioanalytical Chemistry Prospects in the use of aptamers for characterizing the structure and stability of bioactive proteins and peptides in food /
1	Adrián Sánchez. (2017) Food Quality and Safety Bioactive peptides: A review / 1 (1) , 29
11	Ruth Andrew. (2017) British Journal of Pharmacology Principles of pharmacological research of nutraceuticals / 174 (11) , 1177
	Youssef Ali Abou Hamin Neto. (2017) Bioengineered Specificity of peptidases secreted by filamentous fungi / , 1
	M. Felix. (2017) Food and Bioproducts Processing Development of thermally processed bioactive pea protein gels: Evaluation of mechanical and antioxidant properties / 101 , 74
1	Miloš Mitrović. (2017) CEN Case Reports Unusual Listeria monocytogenes peritonitis in peritoneal dialysis patient with liver cirrhosis: a case report and review of literature / 6 (1) , 115
1573-3904	(2018) International Journal of Peptide Research and Therapeutics Tuber Storage Proteins as Potential Precursors of Bioactive Peptides: An In Silico Analysis / (1573-3904)
2	(2017) Oncology Reports Anticancer potential of bioactive peptides from animal sources / 38 (2) , 637
6	(2017) Food Science and Biotechnology Biological activities of lactobacilli relevant to cardiovascular health in skim milk / 26 (6) , 1613
9	(2018) Pakistan Journal of Nutrition Increased Inhibition of Angiotensin Converting Enzyme (ACE) Obtained from Indonesian Buffalo Meat Protein Using SEP-PAK Plus C18 / 17 (9) , 434
1549-7852	(2019) Critical Reviews in Food Science and Nutrition Indigenous African fermented dairy products: Processing technology, microbiology and health benefits / (1549-7852) , 1
1573-3904	(2018) International Journal of Peptide Research and Therapeutics Release of Proteolysis Products with ACE-Inhibitory and Antioxidant Activities in Probiotic Yogurt Containing Different Levels of Fat and Prebiotics / (1573-3904)
15414337	(2018) Comprehensive Reviews in Food Science and Food Safety Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability / (15414337)
1664-302X	(2018) Frontiers in Microbiology Production of Bioactive Peptides by Lactobacillus Species: From Gene to Application / 9 (1664-302X)
7	(2018) International Journal of Molecular Sciences Antioxidant Properties of Buffalo-Milk Dairy Products: A β-Lg Peptide Released after Gastrointestinal Digestion of Buffalo Ricotta Cheese Reduces Oxidative Stress in Intestinal Epithelial Cells / 19 (7) , 1955
1	(2018) Food Biotechnology sps. Based on 16S rRNA Gene Sequencing / 32 (1) , 1
3	(2018) Critical Reviews in Biochemistry and Molecular Biology Cryptides: latent peptides everywhere / 53 (3) , 246
1867-1314	(2018) Probiotics and Antimicrobial Proteins Whey and Its Derivatives for Probiotics, Prebiotics, Synbiotics, and Functional Foods: a Critical Review / (1867-1314)
2	(2018) Nutrients Achieving Optimal Post-Exercise Muscle Protein Remodeling in Physically Active Adults through Whole Food Consumption / 10 (2) , 224
None	(2015) Journal of oncology Casein and Peptides Derived from Casein as Antileukaemic Agents / 2019 (None) , 1
2296-861X	(2019) Frontiers in Nutrition Peptides and Peptidomimetics as Potential Antiobesity Agents: Overview of Current Status / 6 (2296-861X)
09505423	(2019) International Journal of Food Science & Technology Milk and milk-derived peptides combat against hypertension and vascular dysfunction: a review / (09505423)
4	(2019) Molecules Enhanced Anti-Allergic Activity of Milk Casein Phosphopeptide by Additional Phosphorylation in Ovalbumin-Sensitized Mice / 24 (4) , 738
1	(2019) Lipids in Health and Disease Antioxidant properties of Milk and dairy products: a comprehensive review of the current knowledge / 18 (1)
12	(2015) Journal of agricultural and food chemistry An Extensive Description of the Peptidomic Repertoire of the Hen Egg Yolk Plasma / 66 (12) , 3239
3	(2018) Korean journal of agricultural science Characterization of lactoferrin hydrolysates on inflammatory cytokine expression in Raw264.7 macrophages / 45 (3) , 437
4	(2015) Biomolecules Role of Milk-Derived Antibacterial Peptides in Modern Food Biotechnology: Their Synthesis, Applications and Future Perspectives / 8 (4) , 110
12	(2015) Foods One Health, Fermented Foods, and Gut Microbiota / 7 (12) , 195
15	(2019) Analytical and bioanalytical chemistry Identification of bioactive short peptides in cow milk by high-performance liquid chromatography on C18 and porous graphitic carbon coupled to high-resolution mass spectrometry / 411 (15) , 3395
7	(2015) Inorganic chemistry Strong Uranium(VI) Binding onto Bovine Milk Proteins, Selected Protein Sequences, and Model Peptides / 58 (7) , 4173
17	(2015) Current topics in medicinal chemistry Peptides as Potential Anticancer Agents / 19 (17) , 1491
8	(2015) Foods Cheese Whey Processing: Integrated Biorefinery Concepts and Emerging Food Applications / 8 (8) , 347
19	(2019) International journal of molecular sciences The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria / 20 (19) , 4707
10	(2015) Veterinary world Antioxidative activity and protein profile of skim milk of Gaddi goats and hill cattle of North West Himalayan region / 12 (10) , 1535
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8	(2015) Food science and biotechnology Characterization of macrophage stimulating compound in glycated whey protein concentrate / 29 (8) , 1113
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None	(2015) International journal of food science Use of α-Lactalbumin and Caseinoglycomacropeptide as Biopeptide Precursors and as Functional Additives in Milk Beverages Fermented by L. helveticus / 2021 (None) , 1
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5	(2015) Foods Dairy By-Products: A Review on the Valorization of Whey and Second Cheese Whey / 10 (5) , 1067
4	(2021) International journal of food sciences and nutrition Cheese as a functional food for older adults: comparing the bioactive properties of different cheese matrices following simulated gastrointestinal <I>in vitro</I> digestion / 72 (4) , 456
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8	(2015) Journal of food science : an official publication of the Institute of Food Technologists The fermentation‐time dependent proteolysis profile and peptidomic analysis of fermented soybean curd / 86 (8) , 3422
5	(2015) Comprehensive reviews in food science and food safety Applications of novel processing technologies to enhance the safety and bioactivity of milk / 20 (5) , 4652
6	(2021) Food reviews international Opportunities within the Agri-food System to Encourage a Nutritionally Balanced Diet- Part II / 37 (6) , 573
2	(2021) Current research in nutrition and food science journal Investigating The Bioactive Properties of Cheese-Fruit Combinations Following In Vitro Digestion Using an Elderly Model. / 9 (2) , 465
13	(2015) Public health nutrition Nutritional breakfast quality and cardiometabolic risk factors: Health Survey of São Paulo, a population-based study / 24 (13) , 4102
None	(2015) Journal of functional foods : the official journal of the International Society for Nutraceuticals & Functional Foods Whey proteins processing and emergent derivatives: An insight perspective from constituents, bioactivities, functionalities to therapeutic applications / 87 (None) , 104760
1	(2015) Scientific reports Post translational modifications of milk proteins in geographically diverse goat breeds / 11 (1) , 5619
12	(2015) Foods Comparative Peptidomics Analysis of Fermented Milk by Lactobacillus delbrueckii ssp. bulgaricus and Lactobacillus delbrueckii ssp. lactis / 10 (12) , 3028
suppl2	(2015) Nutrition reviews Dairy bioactive proteins and peptides: a narrative review / 79 (suppl2) , 36
None	(2015) Food chemistry Analysis of peptides in a sheep beta lactoglobulin hydrolysate as a model to evaluate the effect of peptide amino acid sequence on bioactivity / 365 (None) , 130346
None	(2015) Trends in food science & technology Hydrolytic enzymes in the dairy industry: Applications, market and future perspectives / 119 (None) , 467
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