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http://dx.doi.org/10.5851/kosfa.2013.33.4.515

Nano-Calcium Ameliorates Ovariectomy-Induced Bone Loss in Female Rats  

Choi, Hyeon-Son (Department of Food and Nutrition, Korea University)
Han, JeungHi (Department of Food and Nutrition, Korea University)
Chung, Seungsik (KC Feed Co. Ltd.)
Hong, Yang Hee (Department of Food and Nutrition, Korea University)
Suh, Hyung Joo (Department of Food and Nutrition, Korea University)
Publication Information
Food Science of Animal Resources / v.33, no.4, 2013 , pp. 515-521 More about this Journal
Abstract
In this study, we examined the effects of organic types of calcium derived from oyster shell (OS-Ca) and nano-calcium (Nano-Ca) on the bio-availability and physiological responses associated with bone health in ovariectomised rats. Increased body weight, which is one of the physiological effects of ovary removal, was significantly recovered by Nano-Ca treatment (p<0.05). The reduced calcium level in the liver in ovariectomised rat was increased significantly with OS-Ca and Nano-Ca treatment (p<0.05), suggesting improved calcium bio-availability. Alkaline phosphatase (ALP), osteocalcin, and deoxypyridinoline (DPD) were analysed as biochemical markers of bone metabolism and health in the presence or absence of OSCa and Nano-Ca. ALP, osteocalcin, and DPD levels increased following ovary removal and tended to decrease after treatment with Nano-Ca, indicating that Nano-Ca induces favourable bone metabolism. This result was reflected in the recovery of bone mineral density (BMD) and bone mineral content (BMC) of the femur after Nano-Ca treatment following ovary removal. Taken together, our data show that the tested calcium treatments, especially using Nano-Ca, enhanced the bioavailability or absorption of calcium and positively affected bone metabolism in ovariectomised rats.
Keywords
ovariectomy; nano-calcium; calcium bioavailability; bone metabolism;
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