A Study of the Efficacy of Hair Analysis Relative to Serum and Organ Analysis for Assessing Heavy Metal Reduction in Living Animals Treated with an Herbal Medicine Remnant and Organic Selenium

This study was carried out to develop a method for decreasing the heavy metal composition of living stock. Sprague-Dawley (SD) male rats were pre-treated with heavy metals administered i.p. at the limits of regulation according to the feed CODEX in Korea. Herbal medicine remnant was administered p.o. (2, 4 ppm of average feeding amount) for the entire period of study with organic selenium (2 ppm of average feeding amount) before any other treatment. 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) was also administered i.p. in a single dose of 60 mg/kg body weight before animals were sacrificed. The TBARS test with the FOX assay demonstrates a decrease of heavy metals due to these functional materials in vitro. Moreover, this decrease in heavy metals was also demonstrated by in vivo tests based on SD rats hair analysis and organ analysis after 6 weeks. A good linear correlation between hair analysis and organ analysis represented by liver and blood was shown. The present findings suggest that measurement method of heavy metal composition using hair analysis for healthy livestock can be used in place of detection methods carried out by organ and blood analysis, and herbal medicines with organic selenium may be very effective at decreasing heavy metals of feed materials in feed manufacture industry.

한약박 및 유기셀레늄이 체내 중금속 축적도에 미치는 영향의 모발 분석과 혈액 및 장기 분석간의 상관도 연구

모발에 축적되는 중금속은 한약박 및 유기셀레늄 같은 기능성 원료에 의해 효과적으로 억제되며, 이는 간 및 혈액으로 대별되는 조직 분석과도 밀접한 상관관계가 보여진다. 또한, 기능성 원료의 여타 효과 즉, 항산화 효과, 항염증 효과 등 부가적인 기능성도 동시에 부여할 수 있는 가치가 있어 산업적인 효용성이 충분히 보장된다고 할 수 있다. 더불어 침체 되어있는 국내 사료산업에 고 부가가치 산업으로서의 기능성 원료를 공급하여 사료산업 활성화에 일조할 수 있으리라 전망한다.