Browse > Article

Antimutagenic Effects of Extracts of Curry Powder and Its Individual Spice  

정승현 (오뚜기중앙연구소)
정명수 (오뚜기중앙연구소)
이진선 (성균관대학교 식품ㆍ생명자원학과)
박기문 (성균관대학교 식품ㆍ생명자원학과)
Publication Information
Food Science of Animal Resources / v.22, no.4, 2002 , pp. 352-357 More about this Journal
Abstract
Antimutagenic effects of extracts from curry powder and its individual fourteen kinds of spices, were investigated by Ames test. The antimutagenic effects against a direct mutagen, 2-nitrofluorene(2 -NF) and two indirect mutagens, 2-anthramine(2-AT) and 2-acetamidofluorene (2-AE) in the S. typhimurium TA98 were tested. For the 2-NF, the antimutagenicity of cinnamon, fenugreek, fennel, ginger, clove, turmeric and celery seed were determined as 42, 38, 32, 28, 24, 23 and 20%, respectively. The antimutagenicity of clove against the 2-AT was the highest (116%), and followed by the order of celery seed(103%), cardamon(100%), red pepper(99%), cinnamon(92%), cumin(83%), ginger(82%), fennel(82%), coriander (71%), nutmeg(68%) and turmeric (55%). The results also showed that the antimutagenic effect of clove against the 2-AF was superior to other spices. In case of curry powder among more than 10 kinds of spices, the antimutagenenicity against the 2-AT and 2-AF showed 23% and 6%, respectively, but no effect was observed against the 2-NF.
Keywords
Antimutagenic effect; curry powder; spice extract;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Ames, B. N. (1983) Dietary carcinogen and anticarcinogens. Sci..221(9), 1256-1264   DOI
2 Azuine, M. A., Kayal, J. J. and Bhide, S. V. (1992) Protectiverole of aqueous turmeric extract against mutagenicity ofdirect-acting carcinogens as well as Benzo(a)Pyrene-inducedgenotoxicity and carcinogenicity. J. Canccr Res. CIin. Oncol.. 118, 447-452   DOI
3 Chithra, V. and Leelamma, S. (2000) Coriandrum sativum-effecton lipid metabolism in 1,2-dimethyl hydrazine induced coloncancer. J. Ethnophurmacotofy, 71, 457-463   DOI   ScienceOn
4 CIare, S. (2001) Curry component may be chemopreventive forcolon cancer. The Lancet Oncotofy, 2, 67
5 Ji, J. H.. Kim, M. N., Choi. K. P., Chung, C. K. and Ham, S. S.(2000) Antimutagenetic and cytotoxicity effects of Agaricus blazeimurill extracts. Kor. J. Food Sci. Technol., 32(6), 1371-1378
6 Jiang. M. C., Yang-Yen. H. F., Yen, J. J. and Lin, J. K. (1996)Curcuimin induced apoptosis in immortalized NIH 3T3 andmalignant cancer cell line. Nutrition and cancer, 26(1), 111-120   DOI   ScienceOn
7 Nalini, N., Sabitha, K.., Viswanathan, P. and Menon, V. P. (1998)Influence of spices on the bacterial(enzyme) activity in experi-mental colon cancer. J. Ethnopharmacolosy, 62, 15-24   DOI   ScienceOn
8 Puneet, S., James, A. H., Mirza, B., Rick, K. and Steven, H. S.(2000) Curcumin : a food spice with cytotoxic activity againsturinary bladder cancer. J. Am. Colt Surg.. 191(4S), 94-95
9 Song, H. S., Lee, II. K-., Choi, E. H. and Kang. M. H. (1999)Effects of perisirnmon leaf tea extract, green tea extract andoolong tea extract on the frequencies of mutagen-induced sisterchromatid exchange in Chinese hamster ovary cells. Kor. J. FoodSci. Technol., 31(3), 823-830
10 Mortelmans, K.. and Zeiger, E. (2000) The Ames Salmonella/microsome mutagenicity assay. Mutation Research, 455, 29-60   DOI
11 Surh, Y. J. (2002) Anti-tumor promoting potential of selected spiceingredients with antioxidative and anti-inflammatory activities: ashort review. Food and Chemical Toxicoloey, 40, 1091-1097   DOI   ScienceOn
12 Yogeshwer, S., A. Arora, and Pankaj T. (2002) Antimutagenicpotential of curcumin on chromosomal aberrations in Wistar rats.Mutation Research, 515, 197-202   DOI
13 Chuang, S. E., Kuo, M. L., Hsu, C. H., Chen, C. R., Lin, J. K..,Lai, G. M., Hsieh, C. Y. and Cheng, A. L. (2000) Curcumincontaining diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinoffenesis, 21(2), 331-335   DOI   ScienceOn
14 Keith, S., Christopher, M. and Matthew, W. (1996) Inhibition byrosemary and carnosol of 7,12-dimethy1benz(a)anthracene(DMBA)induced rat mammary tumorigenesis and in vivo DMBA-DNAadduct formation. Cancer Latters, 104, 43-48   DOI   ScienceOn
15 Nagabhushan, M. and Bhide, S. V. (1987) Antimutagenicity andanticar- cinogenicity of Turmeric(Curcuma longa). J. Nutrition.Growth and Cancer. 4, 83-89
16 Singletary, K. W. and Rokusek, J. T. (1997) Tissue-specificenhancement of xenobiotic detoxification enzymes in mice bydietary rosemary extract. Plant Foods for Human Nutrition. 50(1),47-53   DOI   ScienceOn
17 Chan, M. M., Ho, C. T. and Huang, H. I. (1995) Effects of threedietary phytochemicals from tea, rosemary and turmeric oninflammation-induced nitrite production. Cancer Letters, 96(1),23-29   DOI   ScienceOn
18 Soni, K. B., Lahiri, M., Chackradeo, P., Bhide, S. V. and K-uttan,R. (1997) Protective effect of food additives on aflatoxin-inducedmutagenicity and hetatocarcinogenicity. Cancer Letters, 115, 129-133   DOI   ScienceOn
19 Buening, M. K.., Chang, R. L., Huang, M. T., Fortner, J. G.,Wood, A. W. and Conney, A. H. L. (1981) Activation andinhibition of B(a)P and AFBl metabolism in human livermicrosomes by naturally occurring flavonoids. Cancer Res., 41,67-72
20 Hwang Bo, H J. and Ham, S. S. (1999) Antimutagenic andcvtotoxicity effects of Aster scaber root ethanol extracts. Kor. J.Food Sci. Technol., 31(4), 1065-1070
21 Kim, J. H. and Park, K-. M. (2000) Nitrite scavenging andsuperoxide dismutase-like activities of herbs, spices and curries.
22 Purseglove, J. W., Brown, E. G., Green, C. L. and Robbins, S. R.J. (1981) Spices. Longman Inc. New York. pp .100-286
23 Ham, S. S., Han, H. S., Choi, K-. P. and Oh, D. H. (1997)Inhibitory effects of Synurus deltoids extracts on the mutagenesisinduced by various mutagens. Kor. J. Food Sci. TechnoI, 26(3),528-533