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http://dx.doi.org/10.5856/JKDS.2018.11.2.57

Polydeoxyribonucleotide, as a Novel Approach for the Management of Medication-Related Osteonecrosis of the Jaw: A Preliminary Observational Study  

Jung, Junho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University)
Lim, Hae Soo (E-TOP Dental Clinic)
Lee, Deok-Won (Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University)
Publication Information
Journal of Korean Dental Science / v.11, no.2, 2018 , pp. 57-61 More about this Journal
Abstract
Purpose: Polydeoxyribonucleotide (PDRN), consisting of a mixture of deoxyribonucleotide polymers, has been suggested to have anti-inflammatory effects and enhance angiogenesis as an adenosine $A_{2A}$ receptor agonist. The aim of this study was to report the effectiveness of PDRN as an adjuvant therapy after surgical debridement in MRONJ (medication-related osteonecrosis of the jaw) patients. Materials and Methods: Five patients (1 male, 4 females, age 65~79 years) who were diagnosed with MRONJ stage 2 or 3 underwent surgical debridement and PDRN mucosal injection. After surgical debridement, patients were subject to daily injection with 1 ml of PDRN around the surgical wound for 14 days. Result: The patients' symptoms gradually disappeared. The surgical wound uneventfully healed, and no recurrence was observed during the follow-up period. Conclusion: Although further studies are required, the present study first describes the possibility of PDRN as a useful option for MRONJ treatment.
Keywords
Medication-related osteonecrosis of the jaw; Polydeoxyribonucleotide;
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