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http://dx.doi.org/10.5856/JKDS.2014.7.1.1

Study on Biocompatibility and Mineralization Potential of Capseal  

Bae, Kwang Shik (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Chang, Seok Woo (Department of Conservative Dentistry, School of Dentistry, Kyung Hee University)
Kum, Kee Yeon (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Lee, Woo Cheol (Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Publication Information
Journal of Korean Dental Science / v.7, no.1, 2014 , pp. 1-5 More about this Journal
Abstract
Purpose: Capseal I and Capseal II are calcium silicate and calcium phosphate based experimental root canal sealers. This study sought to evaluate the biocompatibility and mineralization potential of Capseal I and Capseal II. Materials and Methods: The biocompatibility and mineralization related gene expression (alkaline phosphatase [ALP], bone sialoprotein [BSP], and osteocalcin) of Capseal I and Capseal II were compared using methylthiazol tetrazolium assay and reverse transcription-polymerization chain reaction analysis, respectively. The results were analyzed by Kruskal-Wallis test. A P-value of <0.05 was considered significant. Result: Both Capseal I and Capseal II were favorable in terms of biocompatibility, influencing the messenger RNA expression of ALP and BSP. Conclusion: Within the limitation of this study, Capseal is biocompatible, with mineralization promoting potential; thus, it could be a promising root canal sealer.
Keywords
Biocompatibility; Capseal I; Capseal II; Mineralization related gene expression;
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