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http://dx.doi.org/10.7744/kjoas.20200034

Properties of BE0623 to serve as a growth factor of Bifidobacterium  

Cho, Young Hoon (Institute of Research Namyang Dairy Products Co., LTD.)
Sim, Jae Young (Dairy and Food Science Department, South Dakota State University)
Nam, Myoung Soo (Department of Animal Biosystem Science, College of Agriculture and Life Sciences, Chungnam National University)
Publication Information
Korean Journal of Agricultural Science / v.47, no.3, 2020 , pp. 445-457 More about this Journal
Abstract
Prebiotics are defined as "Nondigestible food ingredients that beneficially affect the host by selectively stimulating the growth and activity of bacteria in the intestine" and as defined improve host health. This study was carried out to investigate the effects of bifidobacteria (Bifidobacterium lactis BB12 and Bifidobacterium longum BB536) growth enhancer (BE0623) supplement as a prebiotic. The addition of BE0623, a growth promoting material for bifidobacteria, significantly increased bifidobacteria viable cells counts in fermented milk by about 45 to 75 times compared to the non-added control group. In addition, microscopic observation showed a significant effect on proliferation of bifidobacteria in fermented milk with added BE0623. The viable cell counts in bifidobacteria also increased roughly 102-fold compared to the control group (non-added BE0623) and was higher than that of commercial growth promoters. Each fraction obtained though the purification of BE0623 influenced the increase of bifidobacteria growth. Culturing bifidobacteria with a combination of fractions of BE0623 had a synergistic effect compared to culturing bifidobacteria with each fraction individually. When any of the fractions were not added, the effect of the growth enhancer on bifidobacteria was reduced. These results indicate that all fractions contain substances that promote the growth of bifidobacteria. Therefore, BE0623 is considered to be available as a growth promoting material for bifidobacterium.
Keywords
BE0623; bifidobacteria; growth enhancer; prebiotics; synergistic effect;
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1 Gonzalez NJ, Adhikari K, Sancho-Madriz MF. 2011. Sensory characteristics of peach-flavored yogurt drinks containing prebiotics and synbiotics. LWT-Food Science and Technology 44:158 -163.   DOI
2 Grizard D, Dalle M, Barthomeuf C. 2001. Changes in insulin and corticosterone levels may partly mediate the hypolipidemic effect of guar gum and low-molecular weight pectin in rats. Nutrition Research 21:1185-1190.   DOI
3 Habib NC, Honore SM, Genta SB, Sanchez SS. 2011. Hypolipidemic effect of Smallanthus sonchifolius (yacon) roots on diabetic rats: Biochemical approach. Chemico-Biological Interactions 194:31-39.   DOI
4 Costerton JW, Lewandowski Z, DeBeer D, Caldwell D, Korber D, James G. 1994. Biofilms, the customized microniche. Journal of Bacteriology 176:2137-2142.   DOI
5 Lin YH, Tsai JS, Hung LB, Pan BS. 2011. Plasma lipid regulatory effect of freshwater clam hydrolysate and Gracilaria insoluble dietary fiber. Food Chemistry 125:397-401.   DOI
6 Manning TS, Gibson GR. 2004. Prebiotics. Best Practice & Research Clinical Gastroenterology 18:287-298.   DOI
7 Marin ML, Lee JH, Murtha J, Ustunol Z, Pestka JJ. 1997. Differential cytokine production in clonal macrophage and T-cell lines cultured with bifidobacteria. Journal of Dairy Science 80:2713-2720.   DOI
8 Maxwell FJ, Duncan SH, Hold G, Stewart CS. 2004. Isolation, growth on prebiotics and probiotic potential of novel bifidobacteria from pigs. Anaerobe 10:33-39.   DOI
9 Noriega L, Cuevas I, Margolles A, de los Reyes-Gavilan CG. 2006. Deconjugation and bile salts hydrolase activity by Bifido-bacterium strains with acquired resistance to bile. International Dairy Journal 16:850-855.   DOI
10 Nagendra R, Viswanatha S, Kumar SA, Murthy BK, Rao SV. 1995. Effect of feeding milk formula containing lactulose to infants on fecal bifidobacterial flora. Nutrition Research 15:15-24.   DOI
11 Park HY, Bae EA, Han MJ, Choi EC, Kim DH. 1998. Inhibitory effects of Bifidobacterium spp. isolated from a healthy Korean on harmful enzymes of human intestinal microflora. Archives of Pharmacal Research 21:54-61.   DOI
12 Quigley EM, Quera R. 2006. Small intestinal bacterial overgrowth: Roles of antibiotics prebiotics, and probiotics. Gastroenterology 130(Supplement):S78-S90.   DOI
13 Rada V, Nevoral J, Trojanova I, Tomankova E, Smehilova M, Killer J. 2008. Growth of infant faecal bifidobacteria and clostridia on prebiotic oligosaccharides in in vitro conditions. Anaerobe 14:205-208.   DOI
14 Schiffrin EJ, Rochat F, Link-Amster H, Aeschlimann JM, Donnet-Hughes A. 1995. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. Journal of Dairy Science 78:491-497.   DOI
15 Takahashi H, Yang SI, Hayashi C, Kim M, Yamanaka J, Yamamoto T. 1993. Effect of partially hydrolyzed guar gum on fecal output in human volunteers. Nutrition Research 13:649-657.   DOI
16 Burns AJ, Rowland IR. 2004. Antigenotoxicity of probiotics and prebiotics on faecal water-induced DNA damage in human colon adenocarcinoma cells. Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis 551:233-243.   DOI
17 Zacherl C, Eisner P, Engel KH. 2011. In vitro model to correlate viscosity and bile acid binding capacity of digested water-soluble and insoluble dietary fibers. Food Chemistry 126:423-428.   DOI
18 Zhang N, Huang C, Ou S. 2011. In vitro binding capacities of three dietary fibers and their mixture for four toxic elements, cholesterol, and bile acid. Journal of Hazardous Materials 186:236-239.   DOI
19 Ahn YT, Shin PK, Kim HU. 1997. Growth inhibition of E. coli O157:H7 and Salmonella typhimurium by lactic acid bacteria and bifidobacteria. Journal of Food Hygiene and Safety 12:181-187. [in Korean]
20 Brunser O, Gotteland M. 2010. Chapter 6 - Probiotics and prebiotics in human health: An overview. pp. 73-93. Ronald Ross Watson and Victor R. Preedy. Bioactive Foods in Promoting Health, Academic Press, Boston, USA.
21 Chau CF, Huang YL, Lin CY. 2004. Investigation of the cholesterol-lowering action of insoluble fiber derived from the peel of Citrus sinensis L. cv. Liucheng. Food Chemistry 87:361-366.   DOI
22 Gomes AMP, Malcata FX. 1999. Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, tech nological and therapeutical properties relevant for use as probiotics. Trends in Food Science & Technology 10:139-157.   DOI
23 Eamonn MMQ. 2011. Therapies aimed at the gut micro- biota and inflammation: Antibiotics, prebiotics, probiotics, synbiotics, anti-inflammatory therapies. Gastroenterology Clinics 40:207-222.   DOI
24 Fukushima Y, Kawata Y, Hara H, Terada A, Mitsuoka T. 1998. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. International Journal of Food Microbiology 42:39-44.   DOI
25 Gibson GR, Roberfroid MB. 1995. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. The Jorrnal of Nutrition 125:1401-1412.   DOI