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http://dx.doi.org/10.7744/cnujas.2012.39.2.169

Aldose reductase inhibitory activity of the methanol extracts from Korean folk plants  

Kim, Hye-Min (Department of Integrative Plant Science, Chung-Ang University)
Han, Saem (Department of Integrative Plant Science, Chung-Ang University)
Choi, Kyung (Department of Forest Resource Conservation, Korea National Arboretum)
Ku, Ja-Jung (Department of Forest Resource Conservation, Korea National Arboretum)
Park, Kwang-Woo (Department of Forest Resource Conservation, Korea National Arboretum)
Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University)
Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
Publication Information
Korean Journal of Agricultural Science / v.39, no.2, 2012 , pp. 169-175 More about this Journal
Abstract
To search for the aldose reductase (AR) inhibitors from Korean folk plants, the inhibition of rat lens AR in vitro using the methanol (MeOH) extracts from Korean folk plants was investigated. Among fifty four Korean folk plants tested, the MeOH extract of Cedrela sinensis showed highest inhibition of AR ($IC_{50}$ value, 2.52 ${\mu}g/ml$). The plant C. sinensis has a possibility of new natural resources for the development of AR inhibitor for the prevention of diabetic complications.
Keywords
Aldose reductase inhibition; Cedrela sinensis; Diabetic complications; Folk plant;
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Times Cited By KSCI : 8  (Citation Analysis)
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1 Kim JC, Choi GJ, Lee SW, Kim JS, Chung KY, and Cho KY. 2004. Screening extracts of Achyranthes japonica and Rumex crispus for activity against various plant pathogenic fungi and control of powdery mildew. Pest Manag. Sci. 60: 803-808.   DOI   ScienceOn
2 Kim M. 2004. Korean Endemic Plants. p. 12-16. Solbook Press. Seoul, Korea.
3 Kim SH, Kim JK, Lee YS, Bae YS, Lim SS. 2010b. Inhibitory effect of quercetin-3-O--$\alpha$-L-rhamnopyranoside from Chamaecyparis obtuse on aldose reductase and sorbitol accumulation. Korean J. Med. Crop Sci. 18: 305-310.   과학기술학회마을
4 Kinoshita JH. 1990. A thirty-year journey in the polyol pathway. Exp. Eye Res. 50: 567-73.   DOI   ScienceOn
5 Lee EJ, Kim JS, Kim HP, Lee JH, and Kang SS. 2010. Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities. Food Chem. 120: 134-139.   DOI   ScienceOn
6 Lee S, Shim SH, Kim JS, Shin KH, and Kang SS. 2005. Aldose reductase inhibitors from the fruiting bodies of Ganoderma applanatum. Biol. Pharm. Bull. 28: 1103-1105.   DOI   ScienceOn
7 Matsumoto T, Ono Y, Kurono M, Kuromiya A, Nakamura K, and Bril V. 2008. Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats. J. Pharmacol. Sci. 107: 231-237.   DOI   ScienceOn
8 Mitsui K, Maejima M, Saito H, Fukaya H, Hitotsuyanagi Y, and Takeya K. 2004. Limonoids from Cedrela sinensis. Phytochemistry 65: 3075-3081.   DOI   ScienceOn
9 Mitsui K, Maejima M, Saito H, Fukaya H, Hitotsuyanagi Y, and Takeya K. 2005. Triterpenoids from Cedrela sinensis. Tetrahedron 61: 10569-10582.   DOI   ScienceOn
10 Park HY, Kwon SB, Heo NK, Chun WJ, Kim MJ, and Kwon YS. 2011. Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity. J. Korean Soc. Appl. Biol. Chem. 54: 194-199.   과학기술학회마을   DOI
11 Park JC, Hur JM, Park JG, Kim HJ, Kang KH, Choi MR, Song HS. 2000. Inhibitory effects of various edible plants and flavonoids from the leaves of Cedrela sinensis on human immunodeficiency virus type 1 protease. Int. J. Food Sci. Nutr. 5: 170-173.   과학기술학회마을
12 Sato S, Kador PF. 1990. Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochem. Pharmacol. 40: 1033-1042.   DOI   ScienceOn
13 Song WX, Li S, Wang SJ, Wu Y, Zi JC, Gan ML, Zhang Y, Liu M, Lin S, Yang Y, Shi J. 2008. Pyridinium alkaloidcoupled secoiridoids from the flower buds of Lonicera japonica. Nat. Prod. Sci. 71: 922-925.   DOI   ScienceOn
14 Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M. 2006. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes 55: 2757-2762.   DOI   ScienceOn
15 Van Heyningen R. 1959. Formation of polyol by the lens of the rat with sugar cataract. Nature 184: 194-196.
16 Van Zandt MC, Sibley EO, Mc Cann EE, Combs KJ, Flam B, Sawicki DR. 2004. Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications. Bioorg. Med. Chem. 12: 5661-5675.   DOI   ScienceOn
17 Wang Z, Clifford MN, Sharp P. 2008. Analysis of chlorogenic acids in beverages prepared from Chinese health foods and investigation, in vitro, of effects on glucose absorption in cultured Caco-2 cells. Food Chem. 108: 369-373.   DOI   ScienceOn
18 Xu ML, Hu JH, Wang L, Kim HS, Jin CW, Cho DH. 2010. Antioxidant and anti-diabetes activity of extracts from Machilus thunbergii S. et Z. Korean J. Med. Crop Sci. 18: 34-39.   과학기술학회마을
19 Ward JD. 1973. Advance in metabolic disorders (suppl. 2): The polyol pathway in the neuropathy of early diabetes. p. 425. Academic press. New York, America.
20 WHO. 2002. Word Health Organization Traditional Medicine Strategy 2002-2005. Geneva. 12: 1-74.
21 Bhatnagar A, Srivastava SK. 1992. Aldose reductase: congenial and injurious profiles of an enigmatic enzyme. Biochem. Med. Metab. Biol. 48: 91-121.   DOI   ScienceOn
22 Bak MJ, Jeong JH, Kang HS, Jin KS, Jun M, Jeong WS. 2011. Stimulation of activity and expression of antioxidant enzymes by solvent fractions and isolated compound from Cedrela sinensis leaves in HepG2 cells. J. Med. Food 14: 405-412.   과학기술학회마을   DOI   ScienceOn
23 Beyer-Mears A, Cruz E. 1985. Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. Diabetes 34: 15-21.   DOI   ScienceOn
24 Beyer-Mears A, Ku L, Cohen M. 1984. Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil. Diabetes 33: 604-607.   DOI   ScienceOn
25 Choi CW, Jung HA, Kang SS, Choi JS. 2007. Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. Arch. Pharm. Res. 30: 1-7.   과학기술학회마을   DOI   ScienceOn
26 Constantino L, Rastelli G, Vianello P, Cignarella G, Barlocco D. 1999. Diabetes complications and their potential prevention: aldose reductase inhibition and other approaches. Med. Res. Rev.19: 3-23.   DOI   ScienceOn
27 de la Fuente JA, Manzanaro S. 2003. Aldose reductase inhibitors from natural sources. Nat. Prod. Rep. 20: 243-251.   DOI   ScienceOn
28 Hoareau L, da Silva EJ. 1999. Medicinal plants: A re- emerging health aid. Electr. J. Biotechnol. 2: 56-70.
29 Drel VR, Pacher P, Ali TK, Shin J, Julius U, El-Remessy AB, Obrosova IG. 2008. Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. Int. J. Mol. Med. 21: 667-676.
30 Hamayun M, Khan SA, Sohn EY, Lee IJ. 2006. Folk medicinal knowledge and conservation status of some economically valued medicinal plants of District Swat, Pakistan. Lyonia 11: 101-113.
31 Hotta N, Akanuma Y, Kawamori R, Matsuoka K, Oka Y, Shichiri M, Toyata T, Nakashima M, Yoshimura I, Sakamoto N, Shigeta Y. 2006. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy. Diabetes Care 29: 1538-1544.   DOI   ScienceOn
32 Jung S, Lee JH, Lee YC, Moon HI. 2011. Inhibitory effects of three oleanolic acid glycosides from Achyranthes japonica on the complement classical pathway. Immunopharmacol. Immunotoxicol. 20: 1-3.
33 Kang HS, Chung HY, Son KH, Kang SS, Choi JS. 2003. Scavenging effect of Korean medicinal plants on the peroxynitrite and total ROS. Nat. Prod. Sci. 9: 73-79.   과학기술학회마을
34 Kawanishi K, Ueda H, Moriyasu M. 2003. Aldose reductase inhibitors from the nature. Curr. Med. Chem. 10: 1353-1374.   DOI   ScienceOn
35 Kim HM, Mok SY, Lee JM, Cho EJ, Choi K, Ku J, Park KW, and Lee S. 2010a. Inhibition of aldose reductase from rat lenses by methanol extracts from Korean folk plants. Nat. Prod. Sci. 16: 285-290.   과학기술학회마을