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http://dx.doi.org/10.4041/kjod.2022.52.1.75

Micro-computed tomographic evaluation of the effect of fluoride agents on white spot lesions: An in vitro study  

Hong, Sook-Chan (Major in Dentistry, Department of Medicine, Graduate School of Korea University)
Lee, Dong-Yul (Department of Dentistry, College of Medicine, Korea University)
Kim, Yae-Jin (Department of Orthodontics, Korea University Guro Hospital)
Publication Information
The korean journal of orthodontics / v.52, no.1, 2022 , pp. 75-79 More about this Journal
Abstract
Objective: To investigate remineralizing effect of three fluoride regimens on artificially demineralized enamel around orthodontic bracket by analyzing mineral density (MD) acquired from micro-computed tomography (micro-CT). Methods: Forty-eight bracket bonded bovine incisors were prepared to create demineralized enamel (DE) surface. The samples were divided into four groups according to the fluoride regimen: 1) no fluoridation, 2) 1.23% acidulated phosphate fluoride (APF) gel, 3) fluoridated toothpaste, and 4) 0.05% sodium fluoride mouthwash. Micro-CT was scanned after demineralization (T0), and 2 weeks (T1) and 4 weeks (T2) of fluoridation. Results: APF gel showed highest remineralization of DE during T1-T0 interval among the groups (p < 0.05); followed by toothpaste, mouthwash and no fluoridation. APF gel and toothpaste demonstrated significant increase in MD after 4 weeks of application (p < 0.05). Conclusions: Remineralization effects of three fluoride regimens were depicted through micro-CT analysis, of which APF gel was most effective.
Keywords
Cariology; Fluoride; Micro-computed tomography;
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1 Hadler-Olsen S, Sandvik K, El-Agroudi MA, Ogaard B. The incidence of caries and white spot lesions in orthodontically treated adolescents with a comprehensive caries prophylactic regimen--a prospective study. Eur J Orthod 2012;34:633-9.   DOI
2 Yetkiner E, Wegehaupt F, Wiegand A, Attin R, Attin T. Colour improvement and stability of white spot lesions following infiltration, micro-abrasion, or fluoride treatments in vitro. Eur J Orthod 2014;36:595-602.   DOI
3 Pai N, McIntyre J, Tadic N, Laparidis C. Comparative uptake of fluoride ion into enamel from various topical fluorides in vitro. Aust Dent J 2007;52:41-6.   DOI
4 Willmot D. White spot lesions after orthodontic treatment. Semin Orthod 2008;14:209-19.   DOI
5 al-Khateeb S, Oliveby A, de Josselin de Jong E, Angmar-Mansson B. Laser fluorescence quantification of remineralisation in situ of incipient enamel lesions: influence of fluoride supplements. Caries Res 1997;31:132-40.   DOI
6 Lee YE, Baek HJ, Choi YH, Jeong SH, Park YD, Song KB. Comparison of remineralization effect of three topical fluoride regimens on enamel initial carious lesions. J Dent 2010;38:166-71.   DOI
7 Farhadian N, Miresmaeili A, Eslami B, Mehrabi S. Effect of fluoride varnish on enamel demineralization around brackets: an in-vivo study. Am J Orthod Dentofacial Orthop 2008;133(4 Suppl):S95-8.   DOI
8 Hamba H, Nikaido T, Sadr A, Nakashima S, Tagami J. Enamel lesion parameter correlations between polychromatic micro-CT and TMR. J Dent Res 2012;91:586-91.   DOI
9 ten Cate JM, van de Plassche-Simons YM, van Strijp AJ. Importance of model parameters in the assessment of intra-oral remineralization. J Dent Res 1992;71 Spec No:879-83.   DOI
10 Damen JJ, Exterkate RA, ten Cate JM. Reproducibility of TMR for the determination of longitudinal mineral changes in dental hard tissues. Adv Dent Res 1997;11:415-9.   DOI
11 White DJ. The application of in vitro models to research on demineralization and remineralization of the teeth. Adv Dent Res 1995;9:175-93; discussion 194-7.   DOI
12 Gorelick L, Geiger AM, Gwinnett AJ. Incidence of white spot formation after bonding and banding. Am J Orthod 1982;81:93-8.   DOI
13 Bishara SE, Ostby AW. White spot lesions: formation, prevention, and treatment. Semin Orthod 2008;14:174-82.   DOI
14 Boersma JG, van der Veen MH, Lagerweij MD, Bokhout B, Prahl-Andersen B. Caries prevalence measured with QLF after treatment with fixed orthodontic appliances: influencing factors. Caries Res 2005;39:41-7.   DOI
15 Jo SY, Chong HJ, Lee EH, Chang NY, Chae JM, Cho JH, et al. Effects of various toothpastes on remineralization of white spot lesions. Korean J Orthod 2014;44:113-8.   DOI
16 Sonesson M, Bergstrand F, Gizani S, Twetman S. Management of post-orthodontic white spot lesions: an updated systematic review. Eur J Orthod 2017;39:116-21.   DOI
17 Mielczarek A, Gedrange T, Michalik J. An in vitro evaluation of the effect of fluoride products on white spot lesion remineralization. Am J Dent 2015;28:51-6.
18 Songsiripradubboon S, Hamba H, Trairatvorakul C, Tagami J. Sodium fluoride mouthrinse used twice daily increased incipient caries lesion remineralization in an in situ model. J Dent 2014;42:271-8.   DOI
19 Nakata K, Nikaido T, Nakashima S, Nango N, Tagami J. An approach to normalizing micro-CT depth profiles of mineral density for monitoring enamel remineralization progress. Dent Mater J 2012;31:533-40.   DOI