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http://dx.doi.org/10.4041/kjod.2020.50.6.383

Distribution, side involvement, phenotype and associated anomalies of Korean patients with craniofacial clefts from single university hospital-based data obtained during 1998-2018  

Chung, Jee Hyeok (Department of Plastic and Reconstructive Surgery, Seoul National University Children's Hospital)
Yim, Sunjin (Department of Orthodontics, School of Dentistry, Seoul National University)
Cho, Il-Sik (Private Practice)
Lim, Seung-Weon (Department of Orthodontics, School of Dentistry, Chonnam National University)
Yang, Il-Hyung (Department of Orthodontics, Dental Research Institute, School of Dentistry, Seoul National University)
Ha, Jeong Hyun (Department of Plastic and Reconstructive Surgery, Seoul Metropolitan Government-Seoul National University Boramae Medical Center)
Kim, Sukwha (Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University)
Baek, Seung-Hak (Department of Orthodontics, Dental Research Institute, School of Dentistry, Seoul National University)
Publication Information
The korean journal of orthodontics / v.50, no.6, 2020 , pp. 383-390 More about this Journal
Abstract
Objective: To investigate the distribution, side involvement, phenotype, and associated anomalies of Korean patients with craniofacial clefts (CFC). Methods: The samples consisted of 38 CFC patients, who were treated at Seoul National University Dental Hospital during 1998-2018. The Tessier cleft type, sex, side involvement, phenotype, and associated anomalies were investigated using non-parametric statistical analysis. Results: The three most common types were #7 cleft, followed by #0 cleft and #14 cleft. There was no difference between the frequency of male and female. Patients with #0 cleft exhibited nasal deformity, bony defect, and missing teeth in the premaxilla, midline cleft lip, and eye problems. A patient with #3 cleft (unilateral type) exhibited bilateral cleft lip and alveolus. All patients with #4 cleft were the bilateral type, including a combination of #3 and #4 clefts, and had multiple missing teeth. A patient with #5 cleft (unilateral type) had a posterior openbite. In patients with #7 cleft, the unilateral type was more prevalent than the bilateral type (87.0% vs. 13.0%, p < 0.001). Sixteen patients showed hemifacial microsomia (HFM), Goldenhar syndrome, and unilateral cleft lip and palate (UCLP). There was a significant match in the side involvement of #7 cleft and HFM (87.5%, p < 0.01). Patients with #14 cleft had plagiocephaly, UCLP, or hyperterorbitism. A patient with #30 cleft exhibited tongue tie and missing tooth. Conclusions: Due to the diverse associated craniofacial anomalies in patients with CFC, a multidisciplinary approach involving a well-experienced cooperative team is mandatory for these patients.
Keywords
Craniofacial clefts; Distribution; Phenotype; Associated anomalies;
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Times Cited By KSCI : 6  (Citation Analysis)
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