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The expression of MMP-1, -8, and -13 mRNA in the periodontal ligament of rats during tooth movement with cortical punching  

Gwack, Choon (Department of Orthodontics, School of Dentistry, Pusan National University)
Kim, Seong-Sik (Department of Orthodontics, School of Dentistry, Pusan National University)
Park, Soo-Byung (Department of Orthodontics, School of Dentistry, Pusan National University)
Son, Woo-Sung (Department of Orthodontics, School of Dentistry, Pusan National University)
Kim, Yong-Deok (Department of Oral & Maxillofacial Surgery, School of Dentistry, Pusan National University)
Jun, Eun-Sook (Medical Science Research Institute, Pusan National University Hospital)
Park, Mi-Hwa (Medical Science Research Institute, Pusan National University Hospital)
Publication Information
The korean journal of orthodontics / v.38, no.3, 2008 , pp. 187-201 More about this Journal
Abstract
Objective: The aim of this study was to determine whether cortical punching stimulates the expression of matrix metalloproteinase-1, -8, and -13 in orthodontic tooth movement in rats. Methods: A total of 32 male sprague-dawley rats at 15 weeks old were divided into two groups of 16 rats each, to form the tooth movement with cortical punching (TMC) group and tooth movement only (TM) group. A total of 20 gm of orthodontic force was applied to rat incisors to cause experimental tooth movement. Cortical punching was performed on the palatal side near the central incisor with a 1.0 mm width microscrew in the TMC group. The duration of tooth movement was 1, 4, 7, and 14 days. Results: Measurements of the mRNA expression were selected as the means to determine the identification of expression of MMP-1, -8, and -13. In the TMC group, the expression of collagen type I was greater than that of the TM group from day 4 to day 14. Expression of TIMP-1 in the TM group was greater than that of the TMC group in the pressure side of PDL and alveolar bone cell at day 4. In the TMC group, TIMP-1 was expressed at the osteoclast, but not at the tooth surface of the TM group at day 14, Maximum induction of the mRNA of MMP-1 was observed on day 4 in the TMC group, but it was observed on day 7 in the TM group. MMP-8 mRNA of the TMC group was twice greater than that of the TM group at f days. In the TMC group, maximum induction of MMP-13 mRNA was observed on day 1. Conclusions: These findings suggested that cortical punching can stimulate remodeling of PDL and alveolar bone connective tissues during experimental orthodontic tooth movement in rats.
Keywords
Matrix metalloproteinase; Collagen type I; Cortical punching;
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1 Kryshtalskyj E, Sodek J, Ferrier JM. Correlation of collagenolytic enzymes and inhibitors in gingival crevicular fluid with clinical and microscopic changes in experimental periodontitis in the dog. Arch Oral Biol 1986;31:21-31   DOI   ScienceOn
2 Takahashi I, Nishimura M, Onodera K, Bae JW, Mitani H, Okazaki M, et al. Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats. J Dent Res 2003;82:646-51   DOI   ScienceOn
3 van der Zee E, Everts V, Beertsen W. Cytokines modulate contraction of periosteal explants from rabbit calvariae. Connect Tissue Res 1995;31:141-51   DOI
4 Frost HM. Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's law: the remodeling problem. Anat Rec 1990;226:414-22   DOI   ScienceOn
5 Lauer-Fields JL, Juska D, Fields GB. Matrix metalloproteinases and collagen catabolism. Biopolymers 2002;66:19-32   DOI   ScienceOn
6 Ren Y, Maltha JC, Kuijpers-jagtman AM. The rat as a model for orthodontic tooth movement-a critical review and proposed solution. Eur J Orthod 2004;26:483-90   DOI   ScienceOn
7 Anholm JM, Crites DA, Hoff R, Rathbun WE. Calif Dent Assoc J 1986;14:7-11
8 Lam TS, Abergel RP, Meeker CA, Castel JC, Dwyer RM, Uitto J. Laser stimulation of collagen synthesis in human skin fibroblast cultures. Lasers Life Sci 1986;1:61-77
9 Igarashi K, Miyoshi K, Shinoda H, Saeki S, Mitani H. Diurnal variation in tooth movement in response to orthodontic force in rats. Am J Orthod Dentofacial Orthop 1998;114:8-14   DOI   ScienceOn
10 Kanzaki H, Chiba M, Shimizu Y, Mitani H. Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res 2001;80:887-91   DOI   ScienceOn
11 Ten Cate AR, Freeman E. Collagen remodelling by fibroblasts in wound repair. Preliminary observations. Anat Rec 1974;179:543-6   DOI   ScienceOn
12 Sorsa T, Uitto VJ, Suomalainen K, Vauhkonen M, Lindy S. Comparison of interstitial collagenase from human gingiva, sulcular fluid and polymorphonuclear leukocytes. J Periodontal Res 1988;23:386-93   DOI
13 Kwan Tat S, Padrines M, Théoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 2004;15:49-60   DOI   ScienceOn
14 Berg RA, SchwarTz ML, Crystal RG. Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. Proc NatL Acad Sci USA 1980;77:4746-50   DOI   ScienceOn
15 Takano-Yamamoto T, Kawakami M, Kobayasi Y, Yamashiro T, Sakuda M. The effect of local application of 1,25-dihydroxycholecalciferol on osteoclast numbers in orthodontically treated rats. J Dent Res 1992;71:53-9   DOI   PUBMED   ScienceOn
16 Bosatra M, Jucci A, Olliaro P, Quacci D, Sacchi S. In vitro fibroblast and dermis fibroblast activation by laser irradiation at low energy. An electron microscopic study. Dermatologica 1984;168:157-62   DOI   ScienceOn
17 Harris ED Jr, Krane SM. Collagenases (second of three parts). N Engl J Med 1974;291:605-9   DOI   PUBMED   ScienceOn
18 Holliday LS, Vakani A, Archer L, Dolce C. Effects of matrix metalloproteinase inhibitors on bone resorption and orthodontic tooth movement. J Dent Res 2003;82:687-91   DOI   ScienceOn
19 Tsubota M, Sasano Y, Takahashi I, Kagayama M, Shimauchi H. Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption. J Dent Res 2002;81:673-8   DOI   ScienceOn
20 Beertsen W, Everts V. The site of remodelling of collagen in the periodontal ligament of the mouse incisor. Anat Rec 1977;189:479-97   DOI   ScienceOn
21 Everts V, Wolvius E, Saklatvala J, Beertsen W. Interleukin 1 increases the production of collagenase but does not influence the phagocytosis of collagen fibrils. Matrix 1990;10:388-93   DOI   ScienceOn
22 Iozzo RV. Matrix proteoglycans: from molecular design to cellular function. Annu Rev Biochem 1998;67:609-52   DOI   ScienceOn
23 Circolo A, Welgus HG, Pierce GF, Kramer J, Strunk RC. Differential regulation of the expression of proteinases/antiproteinases in fibroblasts. Effects of interleukin-1 and platelet- derived growth factor. J Biol Chem 1991;266:12283-8   PUBMED
24 van der Zee E, Everts V, Beertsen W. Cytokines modulate routes of collagen breakdown. Review with special emphasis on mechanisms of collagen degradation in the periodontium and the burst hypothesis of periodontal disease progression. J Clin Periodontol 1997;24:297-305   DOI   ScienceOn
25 Wilcko WM, Wilcko T, Bouquot JE, Ferguson DJ. Rapid orthodontics with alveolar reshaping: two case reports of decrowding. Int J Periodontics Restorative Dent 2001;21:9-19   PUBMED
26 Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, et al. Matrix metalloproteinases: a review. Critic Rev Oral Biol Med 1993;4:197-250   DOI
27 Sodek J, Ferrier JM. Collagen remodelling in rat periodontal tissues: compensation for precursor reutilization confirms rapid turnover of collagen. Coll Relat Res 1988;8:11-21   DOI   PUBMED   ScienceOn
28 Redlich M, Reichenberg E, Harari D, Zaks B, Shoshan S, Palmon A. The effect of mechanical force on mRNA levels of collagenase, collagen type I, and tissue inhibitors of metalloproteinases in gingiva of dogs. J Dent Res 2001;80:2080-4   DOI   ScienceOn
29 Parakkal PF. Involvement of macrophages in collagen resorption. J Cell Biol 1969;41:345-54   DOI
30 Harris ED, Cartwright EC. Mammalian collagenases. In: Barrett AJ editor. Proteinases in mammalian cells and tissues. Amsterdam: Elsevier/North Holland Biomedical Press;1997. p. 249-83
31 Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 2000;14:2123-33   DOI   ScienceOn
32 Mester E, Mester AF, Mester A. The biomedical effects of laser application. Lasers Surg Med 1985;5:31-9   DOI   ScienceOn
33 Domon S, Shimokawa H, Matsumoto Y, Yamaguchi S, Soma K. In situ hybridization for matrix metalloproteinase-1 and cathepsin K in rat root-resorbing tissue induced by tooth movement. Arch Oral Biol 1999;44:907-15   DOI   ScienceOn
34 Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, et al. Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article. J Periodontol 1993;64:82-8   DOI   PUBMED   ScienceOn
35 Yamasaki K, Shibata Y, Fukuhara T. The effect of prostaglandins on experimental tooth movement in monkeys (Macaca fuscata). J Dent Res 1982;61:1444-6   DOI   PUBMED   ScienceOn
36 Pfeifer JS. The reaction of alveolar bone to flap procedures in man. Periodontics 1965;3:135-40
37 Rygh P. The periodontal ligament under stress. In: Norton LA, Burstone CJ, editors. The biology of tooth movement. Boca Raton, FL:CRC Press; 1989. p. 9-28
38 Soma S, Yamashita K, Matsumoto S, Takada K. Effect of continuous infusion of PTH on orthodontic tooth movement. J Jpn Orthod Soc Abstr 1997
39 Kryshtalskyj E, Sodek J. Nature of collagenolytic enzyme and inhibitor activities in crevicular fluid from healthy and inflamed periodontal tissues of beagle dogs. J Periodontal Res 1987;22:264-9   DOI
40 Frost HM. The regional accelerated phenomenon. Orthop Clin North Am 1981;12:725-6
41 Salonen J, Uitto VJ, Pan YM, Oda D. Proliferating oral epithelial cells in culture are capable of both extracellular and intracellular degradation of interstitial collagen. Matrix 1991;11: 43-55   DOI   ScienceOn
42 Gronowicz G, Hadjimichael J, Richards D, Cerami A, Rossomando EF. Correlation between tumor necrosis factor-( TNF-alpha)-induced cytoskeletal changes and human collagenase gene induction. J Periodontal Res 1992;27:562-8   DOI
43 Kanzaki H, Chiba M, Shimizu Y, Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 2002;17:210-20   DOI   ScienceOn
44 Melcher AH, Chan J. Phagocytosis and digestion of collagen by gingival fibroblasts in vivo: a study of serial sections. J Ultrastruct Res 1981;77:1-36   DOI
45 Gantes B, Rathbun E, Anholm M. Effects on the periodontium following corticotomy-facilitated orthodontics. Case reports. J Periodontol 1990;61:234-8   DOI   PUBMED
46 Werb Z, Hembry RM, Murphy G, Aggeler J. Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture. J Cell Biol 1986;102:697-702   DOI   ScienceOn
47 Frost HM. The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J 1983;31:3-9
48 Kole H. Surgical operations on the alveolar ridge to correct occlusal abnormalities. Oral Surg Oral Med Oral Pathol 1959;12:515-29   DOI   ScienceOn
49 Kana JS, Hutschenreiter G, Haina D, Waidelich W. Effect of low-power density laser radiation on healing of open skin wounds in rats. Arch Surg 1981;116:293-6   DOI   PUBMED   ScienceOn
50 Beertsen W, Brekelmans M, Everts V. The site of collagen resorption in the periodontal ligament of the rodent molar. Anat Rec 1978;192:305-17   DOI   ScienceOn