Browse > Article

Early histological change in hard tissue from orthodontic force placed on microscrews in ovariectomized rats  

Lee, Dea-Seung (Department of Orthodontics, School of Dentistry, Dankook University)
Chang, Moon-Jung (Department of Food and Nutrition, School of Kookmin University)
Lee, Jin-Woo (Department of Orthodontics, School of Dentistry, Dankook University)
Publication Information
The korean journal of orthodontics / v.36, no.2, 2006 , pp. 103-113 More about this Journal
Abstract
Most elderly women experience a decrease in their bone density due to a deficiency of calcium intake, ovariectomy, or menopause. This study evaluated the usability of the microscrew as a skeletal anchorage system in these orthodontic treatment cases, using rats as a research group. The 4 month old sprague-dawley species rats were divided into two groups, the OS (Ovariectomy Screw), and the SS (Sham operation Screw) group. In both the OS and SS groups, microscrews were implanted into the palatal bone between the upper molar teeth and two upper incisors were retracted using NETE coil spring with 75 g of force. After 3days, the again after 7 days, 7 rats in each group were sacrificed. Three days before they were sacrificed, Alizarin red S was intraperitoneally injected, and their maxillary bone, tibia and blood from their hearts were taken. The components of the extracted blood were biochemically analyzed and non-decalcified grinding resin sections for maxillary bone and tibia were made. The sections were examined with a polarization microscope, and fluorescent microscope. Smaller concentrations of Ca and P, the inorganic substances closely related to bone density, were found in the extracted blood of the OS group. Both OS and SS groups showed a possibility of bone remodeling with a high concentration of ALP after 7 days. An increase in bone density on the tension and compression sides of the microscrew and the tension side of the tooth for both OS and SS groups was confirmed with a polarization microscope. However, the bone density of the pressure side of the tooth and apical side was decreased. More deposits of Alizarin red S in the bone after 7 days rather than 3 days seen with a fluorescent microscope suggested the existence of new bone formation.
Keywords
Ovariectomy; Osteoporosis; Microscrew; Bone remodeling;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Robert WE. Bone biology, metabolism and biomechanics in orthodontic paractice. In: Graber TM, Vanarsdall RL editor. Orthodontics: Current principles and techniques. 2nd. St. Louis: Mosby; 1994. p. 193-234
2 Kusy RP, Tulloch JF. Analysis of moment-force ratios in the mechanics of tooth movement. Am J Orthod Dentofacial Orthop 1986;90:127-31   DOI   ScienceOn
3 Spurrier SW, Hall SH, Joondeph DR, Shapiro PA, Riedel RA. A comparison of apical root resorption during treatment in endodontically orthodontic treated and vital teeth. Am J Orthod Dentofacial Orthop 1990;97:130-4   DOI   ScienceOn
4 Sheridan JJ, Ledoux PM. Air-rotor stripping and proximal sealants. An SEM evaluation. J Clin Orthod 1989;23:790-4
5 Riggs BI, Melton III LJ, Involutional Osteoporosis. N Eng J Med 1983;314:16-77
6 Lane JM, Vigorita VJ. Osteoporosis. Orthop Clin North Am 1984;15:711-28
7 Umemori M, Sugawara J, Mitani H, Nagasaka H, Kawamura H. Skeletal anchorage system for open-bite correction. Am J Orthod Dentofacial Orthop 1999;115:166-74   DOI   ScienceOn
8 Smith JR. Bone dynamics associated with the controlled loading of bioglass-coated aluminum oxide endosteal implants. Am J Orthod 1979;76:618-36   DOI   ScienceOn
9 한상섭. 동물실험법 제 5권 실험외과기술. 서울:정담도서출판; 1999. p, 57-9
10 Ash SL, Goldin BR. Effects of age and estrogen on renal vitamin D metabolism in the female rat. Am J Clin Nutr 1988:47:694-9   DOI
11 Lee HJ. Calcium metabolism of menopausal women. Graduate school ChungAng University:1993
12 Kalu DN. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 1991:15:175-91   DOI   ScienceOn
13 Oesterle LJ, Wood LW. Raising the root: a look at orthodontic extrusion. J am Dent Assoc 1991;122:193-198   DOI
14 Spencer H, Kramer L. NIH Consensus conference. Osteoporosis. Factors contributing to osteoporosis. J Nutr 1986;116:316-9
15 Linder-Aronson S, Nordenram A, Anneroth G. Titanium implant anchorage in orthodontic treatment. An experimental investigation in monkeys. Eur J Orthod 1990;12:414-9   DOI
16 Yun BG. Menopausal symptom. J Kor Med Ass 2000:43:404-11   DOI
17 Mahan LK, Escott-stamp S. Krause's food nutrition & diet therapy. WE Sayder Co; 2000. p. 611-32
18 Han YK, Park WK, Choi EH, Shin HH, Kim SW. A study on hormonal changes and bone densities in Korean menopausal women. J Korean Soc Endocrinol 1989:4:21-6
19 Odman J, Lekholm U, Jemt T, Branemark PI, Thilander B. Osseointegrated titanium implants-a new approach in orthodontic treatment. Eur J Orthod 1988:10:98-105   DOI
20 Heaney RP. The role of nutrition in prevention and management of osteoporosis. Clin Obstet Gynecol 1987:30:833-46   DOI
21 Wennstrom JL, Stokland BL, Nyman S, Thilander B. Periodontal tissue-response to orthodontic movement of teeth with infrabony pockets. Am J Orthod Dentofacial Orthop 1993;103:313-9   DOI   ScienceOn
22 William R. Proffit 최신치과교정학 제3판. 서울:나래출판사; 2000
23 Feldmann I, Feldmann H, Lundstrom F. Nobel Biocare onplants for orthodontic anchoring. A preliminary report onplants for orthodontic anchoring. A preliminary report on 10 patients. J Parodontol Implant Oral 2000;19(Suppl):361-71
24 Kanomi R. Mini-implant for orthodontic anchorage. J Clin Orthod 1997:31:763-7
25 Park YC, Lee SY, Kim DH, Jee SH. Intrusion of posterior teeth using mini-screw implants. Am J Orthod Dentofacial Orthop 2003;123:690-94   DOI   ScienceOn
26 양원식. 서울대학교병원 교정과에 내원한 부정교합환자의 분류 및 분포에 관한 연구. 대치협회지 1990;11:811-21
27 Kleerekoper M, Tolia K, Parfitt AM. Nutritional, endocrine and demographic aspects of osteoporosis. Orthop Clin North Am 1981:12:547-58
28 Roberts WE, Helm FR, Marshall KJ, Gongloff RK. Rigid endosseous implants for orthodontic and orthopedic anchorage. Angle Orthod 1989:59:247-56
29 Amsterdam M. Periodontal prosthesis, twenty-five years in retrospect. Part II. Occlusion. Compend Cantin Edue Dent 1984 5:325-34
30 Diedrich P. Different orthodontic anchorage systems. A critical examination. Fortschr Kieferorthop 1993;54:156-71   DOI
31 Linkow LI. The endosseous blade implant and its use in orthodontics. Int J Orthod 1969:7:149-54
32 Kanomi R. Mini-implant for orthodontic anchorage. J Clin Orthod 1997;31:763-7
33 Roberts WE, Marshall KJ, Mozsary PG. Rigid endosseous implant utilized as anchorage to protract molars and close an atrophic extraction site. Angle Orthod 1990;60:135-52
34 Spear FM, Mathews DM, Kokich VG. Interdisciplinary management of single-tooth implants. Semin Orthod 1997;3:45-72   DOI   ScienceOn
35 Sorenson NA Jr. Use of maxillary intraosseous implants for Class II elastic anchorage. Angle Orthod 1995;65:169-73
36 Genant HK, Cann CE, Ettinger B, Gordan GS. Quantitative computed tomography of vertebral spongiosa. A sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 1982:97:699-705   DOI   ScienceOn
37 Wehrbein H, Glatzmaier J, Mundwiller D, Diedrich P. The Orthosystem -a new implant system for orthodontic anchorage in the palate. J Orofac Orthop 1996:57:142-53   DOI
38 Boyd RL, Leggott PJ, Quinn RS, Eakle WS, Chambers D. Periodontal implications of orthdontic treatment in adults with reduced or normal periodontal tissues versus those of adolescents. Am J Orthod Dentofacial Orthop 1989;96:191-8   DOI   ScienceOn
39 Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr 2000;19:835-995
40 Ziskind D, Schmidt A, Hirschfeld Z. Forced eruption technique: rationale and clinical report. J Prosthet Dent 1998;79:246-8   DOI   ScienceOn
41 Higuchi KW, Slack JM. The use of titanium fixtures for intraoral anchorage to facilitate orthodontic tooth movement. Int J Oral Maxillofac Implants 1991:6:338-44
42 Sherman AJ. Bone reaction to orthodontic forces on vitreous carbon dental implants. Am J Orthod 1978;74:79-87   DOI   ScienceOn
43 Kim WY. Osteoporosis and dietary factors. Korean J Nutrition 1994:27:636-46
44 Haanaes HR, Stenvik A, Beyer-Olsen ES, Tryti T, Faehn O. The efficacy of two-stage titanium implants as orthodontic anchorage in the preprosthodontic correction of third molars in adults-a report of three cases. Eur J Orthod 1991;13:287-92   DOI   ScienceOn
45 Roberts WW 3rd, Chacker FM, Burstone CJ, A segmental approach to mandibular molar uprighting, Am J Orthod 1982;81:177-84   DOI   ScienceOn
46 Lee HO, Lee IH, Rho SN, An SJ, Lee BH. Human nutrition and health. ChungAng University; 1997
47 백형선, 김경훈, 박열. 연세대학교 영동세브란스병원 교정과에 내원한 부정교합자의 분포 및 경향에 관한 연구. 대치교정지 1995;25:87-100
48 Stean H. Clinical case report. An improved technique for using dental implants as orthodontic anchorage. J Oral Implantol 1993;19:336-40
49 Artun J, Urbye KS. The effect of orthodontic treatment on periodontal bone support in patients with advanced loss of marginal periodontium. Am J Orthod Dentofacial Orthop 1988;93:143-8   DOI   ScienceOn
50 Gaomsfprtj BL, Higley LB. A study of orthodontic anchorage possibilities in basal bone. Am J Orthod Oral Surg 1945;31:406-7