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Effects of Indomethacin on the physiologic root resorption of deciduous teeth in dogs  

Shin, Kang-Seob (Department of Orthodontics, College of Dentistry, Kyunghee University)
Kang, Yoon-Goo (Department of Orthodontics, College of Dentistry, Kyunghee University)
Lee, Ki-Soo (Department of Orthodontics, College of Dentistry, Kyunghee University)
Publication Information
The korean journal of orthodontics / v.35, no.2, 2005 , pp. 106-115 More about this Journal
Abstract
This study was aimed to investigate the effects of indomethancin on physiologic root resorption and to examine the dental pulp and tissue changes around the resorbing teeth 13-14 week old six mongrel dogs were divided into 3 groups, two experimental groups administered indomethacin 2mg/kg/day and 8mg/kg/day orally two times a day for 14 days respectively. and control group administered a placebo The deciduous incisors showing root resorption were selected. fixed for 24 hrs in $10\%$ formalin solution. demineralized in $10\%$ EDTA solution. Invested in paraffin and sectioned in $5{\mu}m$ thick sections. The preparations were stained with H&E staining and Masson's trichrome staining and examined under the light microscope Observation revealed that deciduous root resorbing tissue resembles inflammatory tissue and accompanies bore remodelling. The dental pulp was formal except the area near root resorption. well organized columnar odontoblasts layer under the predentin, anud the odontoblasts near root resorption were cuboidal or flat cells in the disrupted layer under the predentin. Indomethacin administered group showed a partial decrease in the number of odontoclasts and nucleus But there was no sign of pulp change by indomethacin. These results suggest that indomethacin inhibits recruitment of odontoclasts partially and that of osteoclasts more. and so when it is administered for long periods deciduous root resorption can be delayed and eruption of the successor can be delayed for a short period.
Keywords
Indomethacin; Physiologic root resorption; Odontoclast; Osteoclast;
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