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http://dx.doi.org/10.7464/ksct.2021.27.1.55

Adsorption of Antibiotics on Serum Albumin Nanoparticle  

Kim, Hyunji (Department of Chemical Engineering, Pukyong National University)
Lim, Sung In (Department of Chemical Engineering, Pukyong National University)
Publication Information
Clean Technology / v.27, no.1, 2021 , pp. 55-60 More about this Journal
Abstract
Antibiotics are compounds broadly used to treat patients with infectious diseases and to enhance productivity in agriculture, fisheries, and livestock industries. However, due to the overuse of antibiotics and their low biodegradability, a substantial amount of antibiotics is leaking into the sewer, subsequently resulting in pollution and the emergence of antibiotic-resistant bacteria. This study explores biodegradable serum albumin's potential as an adsorbent to remove antibiotics from water. Serum albumin is a natural blood protein that transports various metabolites and hormones to all tissues' extravascular spaces. While serum albumin is highly water-soluble, it has intrinsic binding sites which readily accommodate ionic, hydrophilic, or hydrophobic molecules, rendering it a good building block for a nano-adsorbent. To induce coacervation, a desolvating agent, ethanol, was added dropwise into the aqueous albumin solution, resulting in dehydration and liquid-liquid phase separation of albumins into albumin nanoparticles within a size range of 150 ~ 170 nm. The addition of glutaraldehyde as a cross-linker improved the size stability and homogeneity of albumin nanoparticles. Adsorption of amoxicillin antibiotics on albumin nanoparticles was dependent upon glutaraldehyde concentration used in desolvation and pH during adsorption. The maximum adsorption capacity measured by spectrophotometry was found to be 12.4 micrograms of amoxicillin per milligram of albumin nanoparticle. These results demonstrate serum albumin's potential as a building block for fabricating a natural nano-adsorbent to remove antibiotics from water.
Keywords
Albumin; Nanoparticle; Antibiotics; Adsorption; Amoxicillin;
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1 Putra, E. K., Pranowo, R., Sunarso, J., Indraswati, N., and Ismadji, S., "Performance of Activated Carbon and Bentonite for Adsorption of Amoxicillin from Wastewater: Mechanisms, Isotherms and Kinetics," Water Res., 43(9), 2419-2430 (2009).   DOI
2 Zha, S. xing, Zhou, Y., Jin, X., and Chen, Z., "The Removal of Amoxicillin from Wastewater Using Organobentonite," J. Environ. Manage., 129, 569-576 (2013).   DOI
3 Dorne, J. L. C. M., Ragas, A. M. J., Frampton, G. K., Spurgeon, D. S., and Lewis, D. F., "Trends in Human Risk Assessment of Pharmaceuticals," Anal. Bioanal. Chem., 387(4), 1167-1172 (2007).   DOI
4 Fent, K., Weston, A. A., and Caminada, D., "Ecotoxicology of Human Pharmaceuticals," Aquat. Toxicol., 76(2), 122-159 (2006).   DOI
5 Du, Y., Zhang, S., Guo, R., and Chen, J., "Understanding the Algal Contribution in Combined UV-algae Treatment to Remove Antibiotic Cefradine," RSC Adv., 5(74), 59953-59959 (2015).   DOI
6 Berendonk, T. U., Manaia, C. M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F., Burgmann, H., Sorum, H., Norstrom, M., Pons, M. N., Kreuzinger, N., Huovinen, P., Stefani, S., Schwartz, T., Kisand, V., Baquero, F., and Martinez, J. L., "Tackling Antibiotic Resistance: the Environmental Framework," Nat. Rev. Microbiol., 13(5), 310-317 (2015).   DOI
7 Gao, P., He, S., Huang, S., Li, K., Liu, Z., Xue, G., and Sun, W., "Impacts of Coexisting Antibiotics, Antibacterial Residues, and Heavy Metals on the Occurrence of Erythromycin Resistance Genes in Urban Wastewater," Appl. Microbiol. Biotechnol., 99(9), 3971-3980 (2015).   DOI
8 "The Korean Ministry of Environment Press Release - 'Detection of Some Pharmaceutical Substances Including Antibiotics in Major Rivers,'" http://www.me.go.kr/home/web/board/read.do?menuId=286&boardMasterId=1&boardCategoryId=39&boardId=162825 (accessed Jan. 28, 2021).
9 Hena, S., Gutierrez, L., and Croue, J. P., "Removal of Pharmaceutical and Personal Care Products (PPCPs) from Wastewater Using Microalgae: A Review," J. Hazard. Mater., 403, 124041 (2021).   DOI
10 Guo, R., and Chen, J., "Application of Alga-Activated Sludge Combined System (AASCS) as a Novel Treatment to Remove Cephalosporins," Chem. Eng. J., 260, 550-556 (2015).   DOI
11 El Shenawy, E. A., Elkelawy, M., Bastawissi, H. A. E., Taha, M., Panchal, H., kumar Sadasivuni, K., and Thakar, N., "Effect of Cultivation Parameters and Heat Management on the Algae Species Growth Conditions and Biomass Production in a Continuous Feedstock Photobioreactor," Renew. Energy, 148, 807-815 (2020).   DOI
12 Malakootian, M., Yaseri, M., and Faraji, M., "Removal of Antibiotics from Aqueous Solutions by Nanoparticles: a Systematic Review and Meta-analysis," Environ. Sci. Pollut. Res., 26(9), 8444-8458 (2019).   DOI
13 Van Wieren, E. M., Seymour, M. D., and Peterson, J. W., "Interaction of the Fluoroquinolone Antibiotic, Ofloxacin, with Titanium Oxide Nanoparticles in Water: Adsorption and Breakdown," Sci. Total Environ., 441, 1-9 (2012).   DOI
14 de Sousa, D. N. R., Insa, S., Mozeto, A. A., Petrovic, M., Chaves, T. F., and Fadini, P. S., "Equilibrium and Kinetic Studies of the Adsorption of Antibiotics from Aqueous Solutions onto Powdered Zeolites," Chemosphere, 205, 137-146 (2018).   DOI
15 Yu, K., Sun, C., Zhang, B., Hassan, M., and He, Y., "Size-dependent Adsorption of Antibiotics onto Nanoparticles in a Field-scale Wastewater Treatment Plant," Environ. Pollut., 248, 1079-1087 (2019).   DOI
16 "WHO Report on Surveillance of Antibiotic Consumption," (2016).
17 Aydin, S., Aydin, M. E., Beduk, F., and Ulvi, A., "Removal of Antibiotics from Aqueous Solution by Using Magnetic Fe3O4/red Mud-nanoparticles," Sci. Total Environ., 670, 539-546 (2019).   DOI
18 Adams, L. K., Lyon, D. Y., and Alvarez, P. J., "Comparative Eco-toxicity of Nanoscale TiO2, SiO2, and ZnO Water Suspensions," Water Res., 40(19), 3527-3532 (2006).   DOI
19 Rahimizadeh, P., Yang, S., and Lim, S. I., "Albumin: An Emerging Opportunity in Drug Delivery," Biotechnol. Bioprocess Eng., 25(6), 985-995 (2020).   DOI
20 Irache, J. M., and Espuelas, S., "Albumin Nanoparticles," in Nanotechnologies for the Life Sciences, Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
21 Sun, S., Xiao, Q. R., Wang, Y., and Jiang, Y., "Roles of Alcohol Desolvating Agents on the Size Control of Bovine Serum Albumin Nanoparticles in Drug Delivery System," J. Drug Deliv. Sci. Technol., 47, 193-199 (2018).   DOI
22 Cheung, D. T., and Nimni, M. E., "Mechanism of Crosslinking of Proteins by Glutaraldehyde I: Reaction with Model Compounds," Connect Tissue Res., 10(2), 187-199 (1982).   DOI
23 Homsirikamol, C., Sunsandee, N., Pancharoen, U., and Nootong, K., "Synergistic Extraction of Amoxicillin from Aqueous Solution by Using Binary Mixtures of Aliquat 336, D2EHPA and TBP," Sep. Purif. Technol., 162, 30-36 (2016).   DOI
24 Weber, C., Kreuter, J., and Langer, K., "Desolvation Process and Surface Characteristics of HSA-nanoparticles," Int. J. Pharm., 196(2), 197-200 (2000).   DOI
25 Anastopoulos, I., Pashalidis, I., Orfanos, A. G., Manariotis, I. D., Tatarchuk, T., Sellaoui, L., Bonilla-Petriciolet, A., Mittal, A., and Nunez-Delgado, A., "Removal of Caffeine, Nicotine and Amoxicillin from (waste) Waters by Various Adsorbents. A Review," J. Environ. Manage., 261, 110236 (2020).   DOI