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http://dx.doi.org/10.7464/ksct.2020.26.1.1

A Green Preparation of Drug Loaded PAc-β-CD Nanoparticles from Supercritical Fluid  

Jang, Min Ki (Department of Image Science & Engineering, Pukyong National University)
Kim, Yong Hun (Department of Image Science & Engineering, Pukyong National University)
Kim, Dong Woo (Composite Materials Application Research Center, Institute of Advanced Composite Materials, Korea Institute of Science and Technology (KIST))
Lee, Si Yun (Department of Image Science & Engineering, Pukyong National University)
Lim, Kwon Taek (Department of Image Science & Engineering, Pukyong National University)
Publication Information
Clean Technology / v.26, no.1, 2020 , pp. 1-6 More about this Journal
Abstract
Rapid expansion of supercritical solution (RESS) process was used to make molsidomine (MOL) loaded peracetyl-β-cyclodextrin (PAc-β-CD) nanoparticles, which were collected into the air. The effect of the concentration of the drug PAc-β-CD (0.5 and 1 wt%), extraction temperature (45 ~ 60 ℃), nozzle length (5 ~ 20 mm) and internal diameter (ID) (50 ~ 150 μm) of a capillary, and spray distance on the particle size and morphology of the resulting particles were investigated. The interaction of a drug and PAc-β-CD was confirmed by 1H-NMR spectroscopy while the particle size was measured by means of a scanning electron microscope. It was found that increasing the temperature from 45 ℃ to 60 ℃ and decreasing the nozzle diameter from 150 μm to 50 μm had an increasing effect on the average particle size, while increasing the spray distance led to a decrease in the average particle size at a constant pressure of 34.5 MPa and temperature of 45 ℃. With 0.5 wt% of PAc-β-CD, the capillary nozzle of short length (5 mm) and small ID (50 μm) gave the smallest size (165 nm). The obtained nanoparticles showed increased dispersity and solubility in oil. The oil suspension of the inclusion complex showed increased sustainability, which can increase the in-vitro controlled release time of the drug.
Keywords
Supercritical carbon dioxide; Rapid expansion of supercritical solution; Peracetyl-${\beta}$-cyclodextrin; Inclusion complex; Controlled drug release;
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Times Cited By KSCI : 2  (Citation Analysis)
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