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http://dx.doi.org/10.13065/jksdh.20190078

Relationship between periodontal disease and level of high-sensitivity C reactive protein in Korean adults  

Son, So-Hyun (Department of Dental Hygiene, Shingu College)
Lee, Eun-Sun (Department of Dental Hygiene, Hanyang Women's University)
Publication Information
Journal of Korean society of Dental Hygiene / v.19, no.6, 2019 , pp. 919-929 More about this Journal
Abstract
Objectives: The purpose of this study was to comprehensively examine the relationship between periodontal disease and high-sensitivity C reactive protein (hs-CRP) level. Methods: This study was conducted using the data from the sixth Korea National Health and Nutrition Examination Survey. SPSS 18.0 for Windows was used for statistical analysis. The data were collected from 4,576 subjects aged ≥19 years. To analyze the association between periodontal disease and hs-CRP level, chi-squared test and logistic regression analysis were used. Results: Consequent to correcting all the disturbance variables, the moderate risk of hs-CRP was 1.39 times higher in patients with periodontal disease than in those without (OR=1.39; 95% CI:1.14-1.69), whereas the high risk of hs-CRP was 1.10 times but there was no statistical significance (OR=1.10; 95% CI:0.79-1.53). Conclusions: Periodontal disease contributes to raising the risk of systemic inflammation and hs-CRP from low to moderate. Periodontal disease is associated with an early rise in hs-CRP.
Keywords
Chronic disease; C-reactive protein; Inflammation; National health and nutrition examination survey; Periodontal diseases;
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1 Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35(4):277-90. https://doi.org/10.1111/j.1600-051X.2007.01173.x   DOI
2 Macedo JF, Ribeiro RA, Machado FC, Assis NM, Alves RT, Oliveira AS, et al. Periodontal disease and oral health-related behavior as factors associated with preterm birth: a case-control study in south-eastern Brazil. J Periodontal Res 2014;49(4):458-64. https://doi.org/10.1111/jre.12124   DOI
3 Natto ZS, Hameedaldain A. Methodological quality assessment of meta-analyses and systematic reviews of the relationship between periodontal and systemic diseases. J Evid Based Dent Pract 2019;19(2):131-9. https://doi.org/10.1016/j.jebdp.2018.12.003   DOI
4 Sgolastra F, Severino M, Pietropaoli D, Gatto R, Monaco A. Effectiveness of periodontal treatment to improve metabolic control in patients with chronic periodontitis and type 2 diabetes: a meta-analysis of randomized clinical trials. J Periodontol 2013;84(7):958-73. https://doi.org/10.1902/jop.2012.120377   DOI
5 Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, et al. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association. Circulation 2012;125(20):2520-44. https://doi.org/10.1161/CIR.0b013e31825719f3   DOI
6 Martin-Cabezas R, Seelam N, Petit C, Agossa K, Gaertner S, Tenenbaum H, et al. Association between periodontitis and arterial hypertension: A systematic review and meta-analysis. Am Heart J 2016;180:98-112. https://doi.org/10.1016/j.ahj.2016.07.018   DOI
7 Pischon N, Heng N, Bernimoulin JP, Kleber BM, Willich SN, Pischon T. Obesity, inflammation, and periodontal disease. J Dent Res 2007;86(5):400-9. https://doi.org/10.1177/154405910708600503   DOI
8 Suvan J, D'Aiuto F, Moles DR, Petrie A, Donos N. Association between overweight/obesity and periodontitis in adults. A systematic review. Obes Rev 2011;12(5):e381-404. https://doi.org/10.1111/j.1467-789X.2010.00808.x   DOI
9 Korean Ministry of Health and Welfare. Korea national health and nutrition examination survey 7th(2016-2017). Seoul: Korea Centers for Disease Control and Prevention; 2019: 9.
10 Korean Ministry of Health and Welfare. Korea national health and nutrition examination survey 6th(2013-2015). Seoul: Korea Centers for Disease Control and Prevention; 2015: 3.
11 Jung JO, Chun JY, Lee KH. The relationship between smoking and periodontal diseases in Korean adults: based on the data from the Korea national health and nutrition examination survey 2010. J Korean Soc Dent Hyg 2013;13(3):481-9. https://doi.org/10.13065/jksdh.2013.13.3.481   DOI
12 Lee ES, Do KY. Relationship between periodontal disease and chronic kidney disease: a systematic review of cohort studies. J Dent Hyg Sci 2017;17(2):160-7. https://doi.org/10.17135/jdhs.2017.17.2.160   DOI
13 Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342(12):836-43. https://doi.org/10.1056/nejm200003233421202   DOI
14 Pan L, Li G, Wan S, Yihuo W, Yang F, Li Z, et al. The association between high-sensitivity C-reactive protein and blood pressure in Yi people. BMC Public Health 2019;19(1):991. https://doi.org/10.1186/s12889-019-7324-x   DOI
15 Ardila CM, Guzman IC. Comparison of serum amyloid A protein and C-reactive protein levels as inflammatory markers in periodontitis. J Periodontal Implant Sci 2015;45(1):14-22. https://doi.org/10.5051/jpis.2015.45.1.14   DOI
16 Lee JH, Kwon JS, Park WS, Kim CK, Kim KM, Kim KN. C-reactive protein detection in gingival crevicular fluid as an acute systemic inflammation biomarker in patients with severe periodontitis. Kor J Dent Mater 2013;40(4):321-6.
17 Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72(9):1221-7. https://doi.org/10.1902/jop.2000.72.9.1221   DOI
18 Ridker PM. Connecting the role of C-reactive protein and statins in cardiovascular disease. Clin Cardiol 2003;26(4 Suppl 3):III39-44. https://doi.org/10.1002/clc.4960261508   DOI
19 Windgassen EB, Funtowicz L, Lunsford TN, Harris LA, Mulvagh SL. C-reactive protein and high-sensitivity C-reactive protein: an update for clinicians. Postgrad Med 2011;123(1):114-9. https://doi.org/10.3810/pgm.2011.01.2252   DOI
20 Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107(3):499-511. https://doi.org/10.1161/01.cir.0000052939.59093.45   DOI
21 Bortoluzzi MC, Traebert J, Lasta R, Da Rosa TN, Capella DL, Presta AA. Tooth loss, chewing ability and quality of life. Contemp Clin Dent 2012;3(4):393-7. https://doi.org/10.4103/0976-237x.107424   DOI
22 Verhagen SN, Wassink AM, van der Graaf Y, Visseren FL. C-reactive protein and incident diabetes in patients with arterial disease. Eur J Clin Invest 2013;43(10):1052-9. https://doi.org/10.1111/eci.12142   DOI
23 Liu HH, Cao YX, Sun D, Jin JL, Zhang HW, Guo YL, et al. High-sensitivity C-reactive protein and hypertension: combined effects on coronary severity and cardiovascular outcomes. Hypertens Res 2019;42(11):1783-93. https://doi.org/10.1038/s41440-019-0293-8   DOI
24 Han DH, Shin HS, Kim MS, Paek D, Kim HD. Group of serum inflammatory markers and periodontitis-metabolic syndrome coexistence in Koreans. J Periodontol 2012;83(5):612-20. https://doi.org/10.1902/jop.2011.110304   DOI
25 Lee JY, Kim GP, Yu BC. Relationship between periodontal diseases and quality of life. J Korean Soc Dent Hyg 2013;13(5):835-43. https://doi.org/10.13065/jksdh.2013.13.05.835   DOI
26 Liu K, Liu Q, Chen W, Liang M, Luo W, Wu X, et al. Prevalence and risk factors of CKD in Chinese patients with periodontal disease. PLoS One 2013;8(8):e70767. https://doi.org/10.1371/journal.pone.0070767   DOI