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http://dx.doi.org/10.13065/jksdh.2014.14.02.287

Effect of autophagy in human tongue squamous cell carcinoma SCC 25 cells from Scutellariae Radix by ethanol extract  

Choi, Byul Bo-Ra (Department of Dental Hygiene, Dongseo University)
Publication Information
Journal of Korean society of Dental Hygiene / v.14, no.2, 2014 , pp. 287-292 More about this Journal
Abstract
Objectives : The purpose of the study is to examine the cell growth effect and autophagy effect of Scutellariae Radix by ethanol extract in SCC 25 cells. Methods : Cell growth inhibitory effect and autophagy induced by Scutellariae Radix were confirmed by WST-1 assay, monodansylcadaverine(MDC) stain, and flow cytometry by acridine orange(AO) stain. Results : The Scutellariae Radix treatment decreased the cell proliferation in a dose and time dependent manner. Scutellariae Radix has anticancer effects that autophagic vacuoles were apparent by MDC and AO staining in SCC 25 cells. Conclusions : Scutellariae Radix showed anticancer activity against SCC 25 cells via autophagy. The data provided the possibility that Scutellariae Radix may potentially contribute to oral cancer treatment.
Keywords
autophagy; Scutellariae Radix; squamous cell carcinoma;
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