Browse > Article

Dental Treatment of Children with CATCH 22 Syndrome: Case Report  

Kim, Mi Sun (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Lee, Soo Eon (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Ahn, Hyo Jung (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Park, Jae-Hong (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Choi, Sung Chul (Department of Pediatric Dentistry and Institute of Oral Biology, School of Dentistry, Kyung Hee University)
Publication Information
Journal of The Korean Dental Society of Anesthesiology / v.13, no.1, 2013 , pp. 13-18 More about this Journal
Abstract
CATCH 22 syndrome is a one of the most common chromosome microdeletion syndrome with multiple organ anomalies in humans, with an incidence of approximately 1:4,000 to 1:5,000 live births. It is caused by a microdeletion of 1.5 to 3.0 megabases on the long arm of chromosome 22. The phenotypic spectrum of this disorder is wide and various. A 19-year-old patient who showed delayed growth and development (Height; 110 cm, Weight; 18 kg) was referred to our department for the treatment of dental cavities. She was diagnosed as CATCH 22 syndrome in 2004. Physical examination revealed hypertelorism, a short philtrum, thick reflected lips and a small mouth. She underwent cleft palate surgery at 1 year of age and heart valve surgery due to the cardiovascular abnormality at 13 years of age. Convulsive seizures had persisted until 5 years ago but are well controlled at present. Oral examination showed poor oral hygiene, crowding, prolonged retention on #65, 75 and dental cavities on #16, 21, 65, 26, 36, and 46. Cavity treatment and prophylaxis were performed under general anesthesia. Also continuous follow-up checks have been carrying out with the periodic prophylaxis and dental home education. Problems with numerous cavities and gingivitis which can lead to specific risks are common for CATCH 22 syndrome patients. It is therefore of great importance that these patients are referred to foremost physician and dental specialist for the oral care. In addition, preventive treatment targeting the risk of dental cavities and gingivitis is especially important and, as the syndrome involves many different medical problems, the dental treatment should be carried out in collaboration with the patient's physician.
Keywords
CATCH 22 syndrome; DiGeorge syndrome; Chromosome deletion syndrome;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Muller W, Peter HH, Wilken M, Juppener H, Kallfelz HC, Krohn HP: The Digeorge syndrome. I. Clinical evaluation and course of the partial and compete forms of the syndrome. Eur J. Pediatr 1998; 147: 496-502.
2 Wilson DI, Burn J, Scarmbler P, Goodship J: DiGeorge syndrome: Part of CATCH 22. J Med Genet 1993; 30: 852-6.   DOI
3 American academy of pediatric dentistry: Policy on the Dental home. Pediatric dentistry 2012; 34(6): 24-5.
4 Klingberg G, Oskarsdottir S, Johannesson EL, Noren JG: Oral manifestations in 22q11 deletion syndrome. Int J paediatric dentistry 2002; 12(1): 14-23.
5 Okan Toka, Sven Dittrich, Alexandra Holst: Dental aspects in patients with DiGeorge syndrome. Quintessence international 2010; 41(7): 551-7.
6 Burn J, Takao A, Wilson D: Conotruncal anomaly face syndrome 22q11. J Med Genet 1993; 30: 822-4.   DOI
7 Steven A, Carey JC, Shigeoka AO: Digeorge syndrome and velocadiofacial syndrome. Pediatrics 1990; 85: 530-36.
8 Motzkin B, Marion R, Goldberg R, Shpritzen R, Saenger P: Variable phenotypes in velocardiofacial syndrome with chromosomal deletion. J pediatric dentistry 1993; 123(3): 406-10.
9 Digilio M, Marino B, Giannotti A, Dallapiccola B: Search for 22q11 deletion in non-syndromic conotruncal cadiac defects. Eur J Pediatr 1996; 155: 619-20.   DOI
10 Muller W, Peter HH, Kallfelz HC, Franz A, Rieger CH: The Digeorge sequence. II. Immunologic findings in partial and complete forms of the disorder. Eur J Pediatr 1989; 149: 96-103.   DOI
11 Perez E, Sullivan KE: Chromosome 22q11.2 deletion syndrome Digeorge and velocardiofacial syndrome. Curr Opin Pediatr 2002; 14: 678-83.   DOI
12 Bastian J, Law S, Volger L, Lawton A, Herrod H, Anderson S: Prediction of persistent immunodeficiency in the Digeorge anomaly. J. Pediatr 1989; 115: 391-6.   DOI