Browse > Article
http://dx.doi.org/10.5395/rde.2013.38.4.194

Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis  

Kim, Sahng G. (Division of Endodontics, College of Dental Medicine, Columbia University)
Ryu, Steven I. (Department of Endodontics, School of Dental Medicine, University of Pennsylvania)
Publication Information
Restorative Dentistry and Endodontics / v.38, no.4, 2013 , pp. 194-203 More about this Journal
Abstract
Objectives: To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models. Materials and Methods: The authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation'). Results: Six animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups. Conclusions: With the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.
Keywords
Emdogain; Enamel matrix derivative; Replantation; Root resorption;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, Brownell AG, Jengh SM, Healy KE. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 2000;275:41263-41272.   DOI
2 Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM. Enamel matrix derivative (Emdogain) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Perio Res 2001;36:367-376.   DOI
3 Valentine JC, Pigott TD, Rothstein HR. How many studies do you need? A primer on statistical power for meta-analysis. J Educ Behav Stat 2010;35:215-247.   DOI
4 Andreasen JO, Andreasen FM. Avulsion. In: Andreasen JO, Andreasen FM, Andersson L. Textbook and color atlas of traumatic injuries to the teeth. 4th ed. Oxford: Blackwell Munksgaard; 2007. p444-488.
5 Marcences W, Alessi ON, Traebert J. Causes and prevalence of traumatic injuries to the permanent incisors of school children aged 12 years in Jarague do Sul, Brazil. Int Dent J 2000;50:87-92.   DOI
6 Lee JY, Divaris K. Hidden consequences of dental trauma: the social and psychological effects. Pediatr Dent 2009;31:96-101.
7 Hupp JG, Mesaros SV, Aukhil I, Trope M. Periodontal ligament vitality and histologic healing of teeth stored for extended periods before transplantation. Endod Dent Traumatol 1998;14:79-83.   DOI
8 Andreasen JO, Borum MK, Jacobsen HL, Andreasen FM. Replantation of 400 avulsed permanent incisors. 1. Diagnosis of healing complications. Endod Dent Traumatol 1995;11:51-58.
9 Andreasen JO, Borum MK, Jacobsen HL, Andreasen FM. Replantation of 400 avulsed permanent incisors. 4. Factors related to periodontal ligament healing. Endod Dent Traumatol 1995;11:76-89.   DOI
10 Malmgren B, Malmgren O. Rate of infraposition of reimplanted ankylosed incisors related to age and growth in children and adolescents. Dent Traumatol 2002;18:28-36.   DOI
11 Barbakow FH, Cleaton-Jones PE, Austin JC, Vieira E. Healing of replanted teeth following typical treatment with fluoride solutions and systemic admission of thyrocalcitonin: a histometric analysis. J Endod 1981;7: 302-308.   DOI
12 Kum KY, Kwon OT, Spängberg LS, Kim CK, Kim J, Cho MI, Lee SJ. Effect of dexamethasone on root resorption after delayed replantation of rat tooth. J Endod 2003; 29:810-813.   DOI
13 Lustosa-Pereira A, Garcia RB, de Moraes IG, Bernardineli N, Bramante CM, Bortoluzzi EA. Evaluation of the topical effect of alendronate on the root surface of extracted and replanted teeth. Microscopic analysis on rats' teeth. Dent Traumatol 2006;22:30-35.   DOI
14 Filippi A, Pohl Y, von Arx T. Treatment of replacement resorption by intentional replantation, resection of the ankylosed sites, and Emdogain-results of a 6-year survey. Dent Traumatol 2006;22:307-311.   DOI
15 Flores MT, Andreasen JO, Bakland LK, Feiglin B, Gutmann JL, Oikarinen K, Pitt Ford TR, Sigurdsson A, Trope M, Vann WF Jr, Andreasen FM; International Association of Dental Traumatology. Guidelines for the evaluation and management of traumatic dental injuries. Dent Traumatol 2001;17:193-198.   DOI
16 Filippi A, Pohl Y, von Arx T. Treatment of replacement resorption with Emdogain-preliminary results after 10 months. Dent Traumatol 2001;17:134-138.   DOI
17 Heiji L, Heden G, Svärdström G, Ostgren A. Enamel matrix derivative (Emdogain) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997; 24:705-714.   DOI
18 Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24:658-668.   DOI
19 Lindskog S, Blomlof L, Hammarstrom L. Repair of periodontal tissues in vivo and in vitro. J Clin Periodontol 1983;10:188-205.   DOI
20 Iqbal MK, Bamaas N. Effect of enamel matrix derivative (Emdogain) upon periodontal healing after replantation of permanent incisors in beagle dogs. Dent Traumatol 2001;17:36-45.   DOI
21 Ninomiya M, Kamata N, Fujimoto R, Ishimoto T, Suryono, Kido J, Nagayama M, Nagata T. Application of enamel matrix derivative in autotransplantation of an impacted maxillary premolar: a case report. J Periodontol 2002;73:346-351.   DOI
22 Filippi A, Pohl Y, von Arx T. Treatment of replacement resorption with Emdogain-a prospective clinical study. Dent Traumatol 2002;18:138-143.   DOI
23 Barrett EJ, Kenny DJ, Tenenbaum HC, Sigal MJ, Johnston DH. Replantation of permanent incisors in children using Emdogain. Dent Traumatol 2005;21:269-   DOI
24 Caglar E, Tanboga I, Süsal S. Treatment of avulsed teeth with Emdogain-a case report. Dent Traumatol 2005;21: 51-53.   DOI
25 Chappuis V, von Arx T. Replantation of 45 avulsed permanent teeth: a 1-year follow-up study. Dent Traumatol 2005;21:289-296.   DOI
26 Pohl Y, Filippi A, Kirschner H. Results after replantation of avulsed permanent teeth. II. Periodontal healing and the role of physiologic storage and antiresorptiveregenerative therapy. Dent Traumatol 2005;21:93-101.   DOI
27 Schjǿtt M, Andreason JO. Emdogain does not prevent progressive root resorption after replantation of avulsed teeth: a clinical study. Dent Traumatol 2005;21:46-50.   DOI
28 Araújo M, Hayacibara R, Sonohara M, Cardaropoli G, Lindhe J. Effect of enamel matrix proteins (Emdogain) on healing after re-implantation of 'periodontally compromised' roots. An experimental study in the dog. J Clin Periodontol 2003;30:855-861.   DOI
29 Lam K, Sae-Lim V. The effect of Emdogain gel on periodontal healing in replanted monkeys' teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 97:100-107.   DOI
30 Molina GO, Brentegani LG. Use of enamel matrix protein derivative before dental reimplantation: a histometric analysis. Implant Dent 2005;14:267-273.   DOI
31 Poi WR, Carvalho RM, Panzarini SR, Sonoda CK, Manfrin TM, Rodrigues Tda S. Influence of enamel matrix derivative (Emdogain) and sodium fluoride on the healing process in delayed tooth replantation: histologic and histometric analysis in rats. Dent Traumatol 2007;23:35-41.
32 Guzmán-Martínez N, Silva-Herzog FD, Méndez GV, Martín-Pérez S, Cerda-Cristerna BI, Cohenca N. The effect of Emdogain and 24% EDTA root conditioning on periodontal healing of replanted dog's teeth. Dent Traumatol 2009;25:43-50.   DOI
33 Wiegand A, Attin T. Efficacy of enamel matrix derivatives (Emdogain) in treatment of replanted teeth-a systematic review based on animal studies. Dent Traumatol 2008;24:498-502.   DOI
34 Higgins JPT, Altman DG. Assessing risk of bias in included studies. In: Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 The Cochrane Collaboration; 2011. Available from: http://www.cochrane-handbook.org/. (updated Mar 2011)
35 Saito A, Saito E, Yoshimura Y, Takahashi D, Handa R, Honma Y, Ohata N. Attachment formation after transplantation of teeth cultured with enamel matrix derivative in dogs. J Periodontol 2011;82:1462-1468.   DOI
36 Tsukiboshi M. Autotransplantation of teeth: requirements for predictable success. Dent Traumatol 2002;18:157-180.   DOI
37 Oortgiesen DA, Meijer GJ, Bronchers AL, Walboomers XF, Jansen JA. Fenestration defects in the rabbit jaw: an inadequate model for studying periodontal regeneration. Tissue Eng Part C Methods 2010;16:133-140.   DOI
38 Weinberg MA, Bral M. Laboratory animal models in periodontology. J Clin Periodontol 1999;26:335-340.   DOI
39 Andersson L, Andreasen JO, Day P, Heithersay G, Trope M, Diangelis AJ, Kenny DJ, Sigurdsson A, Bourguignon C, Flores MT, Hicks ML, Lenzi AR, Malmgren B, Moule AJ, Tsukiboshi M; International Association of Dental Traumatology. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol 2012;28:88-96.   DOI
40 Söder PO, Otteskog P, Andreasen JO, Modéer T. Effect of drying on viability of periodontal membrane. Scand J Dent Res 1977;85:164-168.
41 Andreasen JO. Effect of extra-alveolar period and storage media upon periodontal and pulpal healing after replantation of mature permanent incisors in monkeys. Int J Oral Surg 1981;10:43-53.   DOI
42 Trope M. Clinical management of the avulsed tooth: present strategies and future directions. Dent Traumatol 2002;18:1-11.   DOI
43 Blomlöf J, Jansson L, Blomlöf L, Lindskog S. Root surface etching at neutral pH promotes periodontal healing. J Clin Periodontol 1996;23:50-55.   DOI
44 Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 2001;28:181-188.   DOI
45 Qu Z, Laky M, Ulm C, Matejka M, Dard M, Andrukhov O, Rausch-fan X. Effect of Emdogain on proliferation and migration of different periodontal tissue-associated cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:924-931.   DOI