Browse > Article
http://dx.doi.org/10.5395/rde.2012.37.1.2

Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion  

Lee, Jung-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry)
Chang, Ju-Hea (Clinic for Persons with Disabilities, Seoul National University Dental Hospital)
Son, Ho-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry)
Publication Information
Restorative Dentistry and Endodontics / v.37, no.1, 2012 , pp. 2-8 More about this Journal
Abstract
The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broadspectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.
Keywords
Biomimetic remineralization; Chlorhexidine; Cross-linking agent; Dentin bonding; Ethanol wet-bonding; Matrix metalloproteinase;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wong TS, Brough B, Ho CM. Creation of functional micro/nano systems through top-down and bottom-up approaches. Mol Cell Biomech 2009;6:1-55.
2 Girija EK, Yokogawa Y, Nagata F. Apatite formation on collagen fibrils in the presence of polyacrylic acid. J Mater Sci Mater Med 2004;15:593-599.   DOI
3 Gajjeraman S, He G, Narayanan K, George A. Biological assemblies provide novel templates for the synthesis of hierarchical structures and facilitate cell adhesion. Adv Funct Mater 2008;18:3972-3980.   DOI
4 Mai S, Kim YK, Kim J, Yiu CK, Ling J, Pashley DH, Tay FR. In vitro remineralization of severely compromised bonded dentin. J Dent Res 2010;89:405-410.   DOI
5 Kim J, Vaughn RM, Gu L, Rockman RA, Arola DD, Schafer TE, Choi KK, Pashley DH, Tay FR. Imperfect hybrid layers created by an aggressive one-step selfetch adhesive in primary dentin are amendable to biominetic remineralization in vitro. J Biomed Mater Res A 2010;93:1225-1234.
6 Tezvergil-Mutluay A, Agee KA, Hoshika T, Tay FR, Pashley DH. The inhibitory effect of polyvinylphosphonic acid on functional matrix metalloproteinase activities in human demineralized dentin. Acta Biomater 2010;6: 4136-4142.   DOI
7 Kim YK, Gu LS, Bryan TE, Kim JR Chen L, Liu Y, Yoon JC, Breschi L, Pashley DH, Tay FR. Mineralisation of reconstituted collagen using polyvinylphophonic acid/ polyacrylic acid templating matrix protein analogues in the presence of calcium, phosphate and hydroxyl ions. Biomaterials 2010;31:6618-6627.   DOI
8 Hashimoto M, Ohno H, Kaga M, Endo K, Sano H, Oguchi H. In vivo degradation of resin-dentin bonds in humans over 1 to 3 years. J Dent Res 2000;79:1385-1391.   DOI
9 Sano H, Yoshikawa T, Pereira PN, Kanemura N, Morigami M, Tagami J, Pashley DH. Long-term durability of dentin bonds made with a self-etching primer, in vivo. J Dent Res 1999;78:906-911.   DOI
10 Takahashi A, Inoue S, Kawamoto C, Ominato R, Tanaka T, Sato Y, Pereira PN, Sano H. In vivo long-term durability of the bond to dentin using two adhesive systems. J Adhes Dent 2002;4:151-159.
11 De Munck J, van Meerbeek B, Yoshida Y, Inoue S, Vargas M, Suzuki K, Lambrechts P, Vanherle G. Four-year water degradation of total-etch adhesives bonded to dentin. J Dent Res 2003;82:136-140.   DOI
12 Hashimoto M, Ohno H, Sano H, Kaga M, Oguchi H. Degradation patterns of different adhesives and bonding procedures. J Biomed Mater Res B Appl Biomater 2003;66:324-330.
13 Wang Y, Spencer P. Quantifying adhesive penetration in adhesive/dentin interface using confocal Raman microspectroscopy. J Biomed Mater Res 2002;59:46-55.   DOI
14 Sano H, Takatsu T, Ciucchi B, Horner JA, Matthews WG, Pashley DH. Nanoleakage: leakage within the hybrid layer. Oper Dent 1995;20:18-25.
15 Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92:827-839.   DOI
16 Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 1993;4:197-250.   DOI
17 Matchett MD, MacKinnon SL, Sweeney MI, Gottschall-Pass KT, Hurta RA. Blueberry flavonoids inhbit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochem Cell Biol 2005;83:637-643.   DOI
18 Hiraishi N, Yiu CK, King NM, Tay FR, Pashley DH. Chlorhexidine release and water sorption characteristics of chlorhexidine-incororated hydrophobic/hydrophilic resins. Dent Mater 2008;24:1391-1399.   DOI
19 Breschi L, Martin P, Mazzoni A, Nato F, Carrilho M, Tjaderhane L, Visintini E, Cadenaro M, Tay FR, De Stefano Dorigo E, Pashley DH. Use of a specific MMPinhibitor (galardin) for preservation of hybrid layer. Dent Mater 2010;26:571-578.   DOI
20 Al-Ammar A, Drummond JL, Bedran-Russo AK. The use of collagen cross-linking agents to enhance dentin bond strength. J Biomed Mater Res B Appl Biomater 2009;91:419-424.
21 Busenlehner LS, Armstrong RN. Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. Arch Biochem Biophys 2005;433:34-46.   DOI
22 Sela-Passwell N, Rosenblum G, Shoham T, Sagi I. Structural and functional bases for allosteric control of MMP activities: can it pave the path for selective inhibition? Biochim Biophys Acta 2010;1803:29-38.   DOI
23 O'Farrell TJ, Guo R, Hasegawa H, Pourmotabbed T. Matrix metalloproteinase-1 takes advantage of the induced fit mechanism to cleave the triple-helical type I collagen molecule. Biochemistry 2006;45:15411-15418.   DOI
24 Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB. Identification of specific hemopexin-like domain residues that facilirate matrix metalloproreinase collagenolytic activity. J Biol Chem 2009;284:24017-24024.   DOI
25 Tjaderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 1998;77:1622-1629.   DOI
26 Mazzoni A, Pashley DH, Tay FR, Gobbi P, Orsini G, Ruggeri A Jr, Carrilho M, Tjaderhane L, Di Lenarda R, Breschi L. Immunohistochemical identification of MMP-2 and MMP-9 in human dentin: correlative FEI-SEM/TEM analysis. J Biomed Mater Res A 2009;88:697-703.
27 Martin-De Las Heras S, Valenzuela A, Overall CM. The matrix metalloproteinase gelatinase A in human dentine. Arch Oral Biol 2000;45:757-765.   DOI
28 Tjaderhane L, Palosaari H, Wahlgren J, Larmas M, Sorsa T, Salo T. Human odontoblast culture method: the expression of collagen and matrix metalloproteinases (MMPs). Adv Dent Res 2001;15:55-58.   DOI
29 Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res 1995;30:23-33.   DOI
30 Pashley DH, Tay FR, Yiu C, Hashimoto M, Breschi L, Carvalho RM, Ito S. Collagen degradation by hostderived enzymes during aging. J Dent Res 2004;83:216-221.   DOI
31 Nishitani Y, Yoshiyama M, Wadgaonkar B, Breschi L, Mannello F, Mazzoni A, Carvalho RM, Tjaderhane L, Tay FR, Pashley DH. Activation of gelatinolytic/ collagenolytic activity in dentin by self-etching adhesives. Eur J Oral Sci 2006;114:160-166.   DOI
32 Mazzoni A, Pashley DH, Nishitani Y, Breschi L, Mannello F, Tjaderhane L, Toledano M, Pashley EL, Tay FR. Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etchand-rinse adhesives. Biomaterials 2006;27:4470-4476.   DOI
33 Kinney JH, Habelitz S, Marshall SJ, Marshal GW. The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin. J Dent Res 2003;82:957-961.   DOI
34 Calero P, Jorge-Herrero E, Turray J, Olmo N, Lopez de Silanes I, Lizarbe MA, Maestro MM, Arenaz B, Castillo- Olivares JL. Gelatinases in soft tissue biomaterials. Analysis of different crosslinking agents. Biomaterials 2002;23:3473-3478.   DOI
35 Carrilho MR, Tay FR, Donnelly AM, Agee KA, Tjaderhane L, Mazzoni A, Breschi L, Foulger S, Pashley DH. Hostderived loss of dentin matrix stiffness associated with solubilization of collagen. J Biomed Mater Res B Appl Biomater 2009;90:373-380.
36 Chiaraputt S, Mai S, Huffman BP, Kapur R, Agee KA, Yiu CK, Chan DC, Harnirattisai C, Arola DD, Rueggeberg FA, Pashley DH, Tay FR. Changes in resin-infiltrated dentin stiffness after water storage. J Dent Res 2008;87:655-660.   DOI
37 Tay FR, Pashley DH, Kapur RR, Carrilho MR, Hur YB, Garrett LV, Tay KC. Bonding BisGMA to dentin-a proof of concept for hydrophobic dentin bonding. J Dent Res 2007;86:1034-1039.   DOI
38 Sauro S, Watson TF, Mannocci F, Mitake K, Huffman BP, Tay FR, Pashley DH. Two-photon laser confocal microscopy of micropermeability of resin-dentin bonds made with water or ethanol wet bondng. J Biomed Mater Res B Appl Biomater 2009;90:327-337.
39 Sauro S, Toledano M, Aguilera FS, Mannocci F, Pashley DH, Tay FR, Watson TF, Osorio R. Resin-dentin bonds to EDTA-treated vs. acid-etched dentin using ethanol wetbonding. Dent Mater 2010;26:368-379.   DOI
40 Sadek FT, Pashley DH, Ferrari M, Tay FR. Tubular occlusion optimizes bonding of hydrophobic resins to dentin. J Dent Res 2007;86:524-528.   DOI
41 Mohammadi Z, Abbott PV. Antimicrobial substantivity of root canal irrigants and medicaments: a review. Aust Endod J 2009;35:131-139.   DOI
42 Hebling J, Pashley DH, Tjaderhane L, Tay FR. Chlorhexidine arrests subclinical degradation of dentn hybrid layers in vivo. J Dent Res 2005;84:741-746.   DOI
43 Wang Y, Spencer P. Quantifying adhesive penetration in adhesive/dentin interface using confocal Raman microspectroscopy. J Biomed Mater Res 2002;59:46-55.   DOI
44 Carrilho MR, Carvalho RM, Tay FR, Yiu C, Pashely DH. Durability of resin-dentin bonds related to water and oil storage. Am J Dent 2005;18:315-319.
45 Kim J, Uchiyama T, Carrilho M, Agee KA, Mazzoni A, Breschi L, Carvalho RM, Tjaderhane L, Looney S, Wimmer C, Tezvergil-Mutluay A, Tay FR, Pashley DH. Chlorhexidine binding to mineralized versus demineralized dentin powder. Dent Mater 2010;26:771-778.   DOI
46 Carrilho MR, Geraldeli S, Tay F, de Goes MF, Carvalho RM, Tjaderhane L, Reis AF, Hebling J, Mazzoni A, Breschi L, Pashley D. In vivo preservation of the hybrid layer by chlorhexidine. J Dent Res 2007;86:529-533.   DOI
47 Sadek FT, Braga RR, Muench A, Liu Y, Pashley DH, Tay FR. Ethanol wet-bonding challenges current antidegradation strategy. J Dent Res 2010;89:1499-1504.   DOI
48 Zhou J, Tan J, Yang X, Cheng C, Wang X, Chen L. Effect of chlorhexidine application in a self-etching adhesive on the immediate resin-dentin bond strength. J Adhes Dent 2010;12:27-31.
49 Cadenaro M, Pashley DH, Marchesi G, Carrilho M, Antoniolli F, Mazzoni A, Tay FR, Di Lenarda R, Breschi L. Influence of chlorhexidine on the degree of conversion and E-modulus of experimental adhesive blends. Dent Mater 2009;25:1269-1274.   DOI
50 Osorio E, Toledano M, Aguilera FS, Tay FR, Osorio R. Ethanol wet bonding technique sensitivity assessed by AFM. J Dent Res 2010;89:1264-1269.   DOI
51 Nishitani Y, Yoshiyama M, Donnelly AM, Agee KA, Sword J, Tay FR, Pashley DH. Effects of resin hydrophilicity on dentin bond strength. J Dent Res 2006;85:1016-1021.   DOI
52 Malacarne J, Carvalho RM, de Goes MF, Svizero N, Pashley DH, Tay FR, Yiu CK, Carrilho MR. Water sorption/solubility of dental adhesive resins. Dent Mater 2006;22:973-980.   DOI
53 Sadek FT, Braga RR, Muench A, Liu Y, Pashley DH, Tay FR. Ethanol wet-bonding challenges current antidegradation strategy. J Dent Res 2010;89:1499-1504.   DOI
54 Lees S, Page EA. A study of some properties of mineralized turkey leg tendon. Connect Tissue Res 1992;28:263-287.   DOI
55 Tororian D, Lim JE, Price PA. The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralization. J Biol Chem 2007;282:22437-22447.   DOI
56 Chesnick IE, Mason JT, Giuseppetti AA, Eidelman N, Potter K. Magnetic resonance microscopy of collagen mineralization. Biophys J 2008;95:2017-2026.   DOI
57 Tay FR, Pashley DH. Biomimetic remineralization of resin-bonded acid-etched dentin. J Dent Res 2009;88:719-724.   DOI
58 Gu LS, Huffman BP. Arola DD, Kim YK, Mai S, Elsalanty ME, Ling JQ, Pashley DH, Tay FR. Changes in stiffness of resin-infiltrated demineralized dentin after remineralization by a botton-up biomimetic approach. Acta Biomater 2010;6:1453-1461.   DOI
59 George A, Veis A. Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition. Chem Rev 2008;108:4670-4693.   DOI