Browse > Article
http://dx.doi.org/10.5395/JKACD.2002.27.2.175

IN VIVO QUANTITATIVE ANALYSIS OF REMINERALIZATlON EFFECT OF REMINERALIZATlON SOLUTION  

Kim, Myung-Eun (Department of Conservative Dentistry, college of dentistry, Yonsei University)
Jung, Il-Young (Department of Conservative Dentistry, college of dentistry, Yonsei University)
Kum, Kee-Yeon (Department of Conservative Dentistry, college of dentistry, Yonsei University)
Lee, Chang-Young (Department of Conservative Dentistry, college of dentistry, Yonsei University)
Roh, Byoung-Duck (Department of Conservative Dentistry, college of dentistry, Yonsei University)
Publication Information
Restorative Dentistry and Endodontics / v.27, no.2, 2002 , pp. 175-182 More about this Journal
Abstract
Dental caries is a chronic disease that causes the destruction of tooth structure by the interaction of plaque bacteria, food debris, and saliva. There has been attempts to induce remineralization by supersaturating the Intra-oral environment around the surface enamel, where there is incipient caries. In this study, supersaturated remineralized solution "R" was applied to specimens with incipient enamel caries, and the quantitative analysis of remineralization was evaluated using microradiography. Thirty subjects volunteered to participate in this study. Removable appliances were constructed for the subjects, and the enamel specimen with incipient caries were embedded in the appliances. The subjects wore the intra-oral appliance for 15 days except while eating and sleeping. The removable appliance were soaked in supersaturated solution "R", saline, or Senstime$^{\circledR}$ to expose the specimen to those solutions three times a day, 5 minutes each time. After 15 days, microradiography was retaken to compare and evaluate remineralization The results were as the following: 1. The ratio of remineralized area to demineralized area was significantly higher in the supersaturated solution "R" and Senstime$^{\circledR}$ than in the saline (p<0.05) 2. Remineralization in the supersaturated buffer solution "R" occurred in the significantly deeper parts of the tooth. compared to the Senstime$^{\circledR}$ group containing high concentration or fluoride. (p<0.05) As in the above results, the remineralization effect of remineralized buffer solution "R" on incipient enamel caries has been proven. For clinical utilization, further studies on soft tissue reaction and the effect on dentin and cementum are necessary In conclusion compared to commercially available fluoride solution. remineralization solution“R”showed better remineralization effect on early enamel caries lesion, so it is considered as effecient solution for clinical application.
Keywords
Enamel caries; Remineralization solution; Remineralization; Removable oral appliance; Microradiography;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Silverstone, L. M.: Observations on the dark zone in early enamel caries and artificial caries-like lesions., Caries Res., 1:261-274, 1967   DOI
2 Ten Cate JM, Jongebloed WL, Arends J. Remineralization of artificial enamel lesions in vitro IV .Influence of and diphonates in short and long term remineralization., Caries Res., 15:60-69.1981   DOI   ScienceOn
3 Ten Cate JM, Arends J. Remineralization of artificial enamel lesions in vitro. Caries Res., 11:277-286.1977   DOI   ScienceOn
4 Theuns, H. M., Van Dijk, J. W. E., Driessens, F. C. M., and Groeneveld, A.: Effect of time, degree of saturation, pH and acid concentration of buffer solutions on the rate of in-vitro demineralization of human enamel., Archs Oral BioI.. 30:37-42. 1985   DOI   ScienceOn
5 A Thylstrup and O. Fejershov:Textbook of clinical cariology.Second edition,240,1994
6 Wei, SHY : Clinical uses of fluorides. Lea & Febiger, 16-24,1985
7 김소라, 이찬영, 금기연:pH 순환모델에서 과포화 용액의 초기우식 법랑질에 대한 재광화 효과., 대한치과보존학회지, 26:341-349,2001
8 Arends J., Shuthof J., Jongebloed WL: Lesion depth and microhardness indentations on artificial white spot lesions., Caries Res., 14:190-195. 1980   DOI   ScienceOn
9 Brudevold F, McCann HG, Gron P in Wolstenholm. Caries resistant teeth as related to the chemistry of enamel .121Churchill, London. 1965
10 Chow, L. C., and Takagi, S.: Remineralization of Root Lesions with Concentrated Calcium and Phosphate Silutions., Dent. Mat. J.,14:31-36, 1995   DOI
11 Hay Dl,Smith DJ, Schluckebier , Moreno EC Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva., J. Dent. Res., 63:857-63,1984   DOI   PUBMED   ScienceOn
12 Larsen MJ.,Cemically induced in vitro lesions in dental enamel., Scand. J. Dental. Reserch., 82:496-509, 1974
13 Larsen MJ. Degrees of saturation with respect to apatite in parotid saliva at various pH values., Scand. J. Dent. Res., 83:7-12.1975
14 Moreno EC, Zahradnik RT : Chemistry of enamel subsurface demineralization in vitro., J. Dent. Res., 53:226-235, 1974   DOI   ScienceOn
15 Silverstone LM. Remineralization and enamel caries new concepts., Dent. update.10,1983
16 Dawes C and Weatherell JA : Kinetics of fluoride in the oral fluids., J. Dent .Res., 69;638, 1990   DOI   PUBMED
17 Ogaard B, Rolla G, and Helgeland K : Alkali soluble and alkali insoluble fluoride retention in demineralized enamel in vivo., Scand J. Dent. Res., 91: 200, 1983
18 Mellberg JG, Ripa LW, and Leske GS : Fluoride in preventive dentistry, theory and clinical application., Quintessence, 151-179, 1983
19 Ten Bosch J.J., van der Mei H.C., Borsboom P.C.F.: Optical monitor of in vitro caries., Caries Res., 18: 540-548, 1984
20 금기연, 이찬영: 수종의 유기산이 법랑질 인공우식의 형성에 미치는 영향., 대한치과보존학회지, 21: 470-488, 1996
21 Silverstone, L. M.: Structure of carious enamel, including the early lesion., Oral Sci Rev., 3:100-160, 1973
22 Johnson M, Richardson CF, Bergey EJ, Levine MJ, Nancollas GH. The effect of human salivary crystatins and statherin on hydroxyapatite crystallization., Arch oral BioI., 23:993-6,1978   DOI   ScienceOn
23 박정원, 허복, 이찬영 : 유기산 완충용액의 포화도가 법랑질및 상아질의 재광화에 미치는 영향과 산회인회석의 AFM관찰., 대한치과보존학회지,25:459-473,2000
24 Ten Cate JM, Arends J. Remineralization of artificial enamel lesions in vitroIII. A study of the deposition mechanism., Caries Res., 14:351-358,1980   DOI   ScienceOn
25 Clarkson BH, Krell D, Wefel JS, Crall J, Feagin FF : In vitro caries-like lesion produced by Streptococcus mutans and Actinomyces viscosus using sucrose and starch., J. Dent. Res., 66: 795-798, 1987   DOI   ScienceOn
26 오현석, 금기연, 노병덕, 이찬영: 산 완충용액의 pH가 인공치근 우식의 형성에 미치는 영향., 대한치과보존학회지, 24:495-502.1999
27 Backer Dirks O. Posteruptive changes in dental enamel., J. Dent. Res., Sup.3, 45:503-511, 1966   DOI
28 Sperber GH,Bunnocore MG. Enamel surface in whitw spot formation. J. Dent. Res., 42:724-731,1963   DOI   ScienceOn
29 김민경, 금기연, 이찬영: 법랑질 인공우식의 재광화에 미치는 pH의 영향에 관한 연구., 대한치과보존학회지, 22: 193-208, 1997
30 Exterkate. R.A.M., Damen, J.J.M. and Ten Cate, J. M. : A single-section model for enamel de- and remineralization suties. 1. The effects of different Ca/P ratios in Remineralization solutions., J. Dent. Res., 72: 1599-1603, 1993   DOI   ScienceOn
31 박성호, 이찬영, 이정석: 유산완충액을 이용한 인공치아우식의형성에 미치는 산의 농도와 pH에 관한 연구., 대한치과보존학회지, 18: 277-290,1993
32 이찬영 : 산 완충용액을 이용한 인공치아우식 형성., 연세치대논문집, 7: 34-41, 1992
33 한원섭, 금기연 이찬영: 인공치아우식의 재광화에 미치는 불소의 영향., 대한치과보존학회지, 21: 161-173, 1996
34 Moreno, E. C. and Zahradnik, R. T.: Chemistry of enamel subsurface demineralization in vitro., J. Dent. Res., 53:226-235, 1974   DOI   ScienceOn
35 Heilman, J. R., and Wefel, J. S.: Effect of remineralization on demineralized root surfaces., J, Dent. Res., 68:351. 1989
36 Margolis HC, Moreno EC, Murphy BJ. Effect fo low levels of fluoride in solution on enamel deminalization., J. Dent. Res., 65(1):23-29,1986   DOI   ScienceOn
37 김종배, 최유진, 백대일, 신승철, 김동기 : 임상예방치학, 이우출판사, 193-218, 1991
38 Koulourdes T. Implication of remineraliztion in the tratment of dental caries in processing symposium on current topics in dental caries in commemoration of the decenial anniversary of Hihon university school of dentistry at Matsudo, Matsuda, Japan. 198.1982
39 Margolis HC, Murphy BJ, Moreno EC : Development of caries-like lesions in partially saturated lactate buffers. Caries Res., 19: 36-45, 1985   DOI   ScienceOn
40 A Thylstrup and O. Fejershov:Textbook of clinical cariology.Second edition,231.1994
41 Herkstr ter F. M., Noordmans J.. ten Bosch J.J.: Wavelength-independent microradiography: Its use to measure mineral changes in curved and thick samples., Caries Res., 24:399, 1990
42 Wefel JS : Effects of fluorides on careis development and progression using intraoral models., J. Dent. Res., 69:626, 1990