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http://dx.doi.org/10.4047/jkap.2014.52.4.298

Osseointegration of the titanium implant coated with rhTGF-${\beta}2$/PLGA particles by electrospray: a preliminary microCT analyzing rabbit study  

Lee, Woo-Sung (Department of Prosthodontics, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Kim, Seong-Kyun (Department of Prosthodontics, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Heo, Seong-Joo (Department of Prosthodontics, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Koak, Jai-Young (Department of Prosthodontics, Seoul National University Dental Hospital, School of Dentistry, Seoul National University)
Lee, Joo-Hee (Department of Prosthodontics, Asan Medical Center, College of Medicine, University of Ulsan)
Park, Ji-Man (Department of Prosthodontics, Ewha Womans University)
Park, Yoon-Kyung (Department of Dental Research Institute, Brain Korea 21, Seoul National University)
Publication Information
The Journal of Korean Academy of Prosthodontics / v.52, no.4, 2014 , pp. 298-304 More about this Journal
Abstract
Purpose: This preliminary rabbit study was conducted to evaluate the effect of recombinant human transforming growth factor-${\beta}2$ (rhTGF-${\beta}2$)/poly lactic-co-glycolic acid (PLGA) coating on osseointegration of the titanium (Ti) implant. Materials and methods: Eight Ti implants were anodized with 300 voltages for three minutes. Four of those were coated with rhTGF-${\beta}2$/PLGA by an electrospray method as the experimental group. The implants were placed into tibiae of four New Zealand rabbits, two implants per a tibia, one implant per each group. After 3 and 6 weeks, every two rabbits were sacrificed and micro-computed tomography (microCT) was taken for histomorphometric analysis. Results: In scanning electron microscope (SEM) image, the surface of rhTGF-${\beta}2$/PLGA coated Ti implant showed well distributed particles. Although statistically insignificant, microCT analysis showed that experimental group has higher bone volume / total volume (BV/TV) and trabecular thickness (Tb.Th) values relatively. Cross sectional view also showed more newly formed bone in the experimental group. Conclusion: In the limitation of this study, rhTGF-${\beta}2$/PLGA particles coating on the Ti implant show the possibility of more favorable quantity of newly formed bone after implant installation.
Keywords
TGF-beta2; PLGA; Titanium; Implant; Osseointegration;
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