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http://dx.doi.org/10.5392/JKCA.2020.20.06.124

Anticancer Effects of Cisplatin in Combination with Paeonia Japonica in YD-10B Cells  

Kim, Eun-Jung (상지대학교 보건의료과학대학 임상병리학과)
Publication Information
The Journal of the Korea Contents Association / v.20, no.6, 2020 , pp. 124-130 More about this Journal
Abstract
The present study investigated the anti-proliferate and anti-invasive of Phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP-2) and MMP-9 activities of combined treatment with cisplatin and ethyl acetate fractions of Paeonia japonica. Cell Proliferation was detected by the MTS assay and the activity and mRNA expression of MMP-2/-9 were examined by zymography and RT-PCR. As results, cisplatin or p. japonica treatment of YD-10B cells resulted in a dose-dependent inhibition of cell growth. Also, the viability of YD-10B cells treated with combination of 200 μM cisplatin and 50 ㎍/ml p. japonica was inhibited to 50% in compared with the cisplatin alone. In PMA-treated YD-10B cells, co-treatment of 200 μM cisplatin with 50 ㎍/ml p. japonica significantly inhibited mRNA expression and protein activation of MMP-2/-9. Therefore, This study suggest that the combination treatment of cisplatin and p. japonica potentiates a promising anti-invasive agent and has more potential anti-cancer drug for oral cancer therapy than cisplatin alone.
Keywords
Combination; Cisplatin; Paeonia Japonica; Anticancer; YD-10B Cells;
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1 J. K. Kim and H. O. Yang, "The cytotoxic effect of chaga mushroom water extract on HepG2 hepatoma cells," J. Exp. Biomed Sci., Vol.17, pp.253-260, 2011.
2 김태희, 김안근, "MCF-7에서 Cisplatin과 타우린의 병용처리로 인한 항암효과 및 관련 기전," 약학회지, Vol.57, pp.18-23, 2013.
3 H. Song, L. Xiaolin, X. Rongrong, Y. Lingyun, K. Hui, Z. Xiaoning, W. Hong, and X. Weiping, "The synergistic effect of resveratol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells," Acta. Biochim. Biophys. Sin., Vol.48, pp.528-535, 2016.   DOI
4 E. J. Kim and J. H. kim, "Evaluation of Anti-oxidative, Anti-thrombin, Anti-invasive and Pro-apoptotic Activities of Paeonia japonica," Korean. J. Plant. Res., Vol.31, pp.16-23, 2018.   DOI
5 O. Kujan, A. M. Glenny, J. Duxbury, N. Thakker, and P. Sloan, "Evaluation of screening strategies for improving oral cancer mortality: a Cochrane systematic review," J. Dent. Educ., Vol.69, pp.255-265, 2005.   DOI
6 L. Muzio, A. Santarelli, V. Panzarella, G. Campisi, M. Carella, D. Ciavarella, M. Cosola, N. Giannone, and A. Bascones, "Oral squamous cell carcinoma and biological markers: an update on the molecules mainly involved in oral carcinogenesis," Minerva. Stomatol., Vol.56, pp.341-347, 2007.
7 C. Klug, D. Berzaczy, M. Voracek, and W. Millesi, "Preoperative chemoradiotherapy in the management of oral cancer," J. Craniomaxillofac. Surg., Vol.36, pp.75-88, 2008.   DOI
8 C. Y. Ng, H. Yen, H. Y. Hsiao, and S. G. Su, "Phytochemicals in skin cancer prevention and treatment: an updated review," int. J. Mol. Sci., Vol.19, pp.941-965, 2018.   DOI
9 C. Y. Sun, Q. Y. Zhang, G. J. Zheng, and B. Feng, "Phytochemicals: current strategy to sensitize cancer cells to cisplatin," Biomed Pharmocather., Vol.110, pp.518-527, 2019.   DOI
10 L. Xin, G. Shu, X. K. Xiong, B. Y. Peng, J. M. Huang, M. F. Cehn, and F. Y. Wang, "Combination of quercetin and cisplatin emhances apoptosis in OSCC cells by downregulating xIAP through the NF-kB pathway," J. Cancer, Vol.10, pp.4509-4521. 2019.   DOI
11 서종천, 성일용, 김종렬 "구강편평세포암종에서의 cisplatin 유도 아폽토시스에서의 NF-kB의 활성화," 대구외지, Vol.32, pp.94-100, 2006.
12 L. Kelland, "The resurgence of platinum-based cancer chemotherapy," Nat. Rev. Cancer, Vol.7, pp.573-584, 2007.   DOI
13 A. B. Kocka, N. Vorobets, M. Chrząscz, W. Pietrzak, and K. Szewczyk, "Polyphenol Composition of Extracts of the Fruits of Laserpitium Krapffii Crantz and Their Antioxidant and Cytotoxic Activity," Antioxidants, Vol.8, pp.363-382, 2019.   DOI
14 K. Tao, Y. Yin, Q. Shen, Y. Chen, R. Li, and W. Chang, "Akt inhibitor MK-2206 enhances the effect of cislatin in gastric cancer cells," Biomed Rep., Vol.4, pp.365-368, 2016.   DOI
15 P. Baharuddin, N. Satar, K. S. Fakiruddin, N. Zakaria, M. N. Lim, and N. M. Yusoff, "Curcumin improves the efficacy of cisplatin by targeting cancer stem like cells through p21 and cyclinD1-mediated tumor cell inhibition in non-small cell lung cancer cell lines," Oncol Rep., Vol.35, pp.13-25, 2016.   DOI
16 P. Ciganovic, K. Jakimiuk, M. Tomczyk, and M. K. Zovko, "Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients: Extraction Optimization, Chemical Characterization, and Biological Activity," Antioxidants, Vol.8, pp.445-459, 2019.   DOI
17 L. Bordoni, D. Fedeli, C. Nasuti, F. Maggi, F. Papa, M. Wabitsch, R. D. Caterina, and R. Gabbianelli, "Antioxidant and anti-inflammatory properties of nigella sativa oil in human pre-adipocytes," Antioxidants, Vol.8, pp.51-63, 2019.   DOI
18 H. R. Park, E. J. Ju, S. K. Jo, U. Jung, S. H. Kim, and S. T. Yee, "Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice," BMC Cancer, Vol.9, pp.85-90, 2009.   DOI
19 Y. Yang, Q. Zhang, Y. Chen, C. L. Liang, H. Liu, and F. Qiu, "Antitumoreffects of immunity enhancing traditional chinese medicine," Biomed Pharmocather., Vol.121, pp.1-9, 2020.
20 E. H. Kim, S. Baek, D. Shin, J. Lee, and J. L. Roh, "Hederagenin induces apoptosis in cisplatin-resistant head and neck cancer cells by inhibiting the Nrf2-ARE antioxidant pathway," Oxid. med. Cell. Longev., Vol.2017, pp.1-12, 2017.
21 C. H. Yuan, C. T. Horng, C. F. Lee, N. N. Chiang, F. J. TSai, C. C. Lu, J. H. Chiang, Y. M. Hsu, J. S. Yang, and F. A. Chen, "Epigallocatecnin gallate sensitizes cisplatin-resistant oral cancer CAR cells apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multig\drug resistance 1 signaling," Envrion Toxicol., Vol.32, pp.845-855, 2017.   DOI
22 S. Li, X. Y. Shen, T. ouyang, Y. Qu, T. Luo, and H. Q. Wang, "Synergistic anticancer effect of combined crocetin and cisplatin on KYSE-150 cells via p53/p21 pathway," Cancer Cell int., Vol.17, pp.1-18, 2017.   DOI
23 N. Toshiki, O. Akinobu, O. Takayuki, K. Hiroyuki, F. Akifumi, O. Yukinobu, Y. Yoichi, H. Yoshitaka, and K. Yoshiaki, "Combined arsenic trioxide-cisplatin treatement enhances apoptosis in oral squamous cell carcinoma cells," Cell Oncol, Vol.37, pp.119-129, 2014.   DOI
24 X. Chen, Y. Wu, C. Y. Zhang, and Y. Zhang, "Platinum based agents for individualized cancer treatment," Curr. Mol. Med., Vol.13, pp.1603-1612, 2013.   DOI
25 S. Dilruba and G. V. Kalayda, "Platinum based gruds: past, present and future," Cancer chemother. Pahrmacol., Vol.7, pp.1103-1124, 2016.