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http://dx.doi.org/10.5392/JKCA.2017.17.10.289

Association between the Polymorphism of Glutathione S-transferase Genes and Chronic Myeloid Leukemia in Asian Population: a Meta-analysis  

Kim, Hee Sung (단국대학교 의과대학 제일병원 진단검사의학과)
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The Journal of the Korea Contents Association / v.17, no.10, 2017 , pp. 289-299 More about this Journal
Abstract
To verify the association between susceptibility to chronic myeloid leukemia (CML) and GSTM1, GSTT1 gene polymorphisms in Asian populations, 9 papers published until July 2017 were cited in a meta-analysis. The null present types of the GSTM1, GSTT1 gene were analyzed individually. The significant association was found between CML and GST polymorphism (GSTM1; OR=1.306, 95% CI=1.091-1.563, p=0.004, GSTT1; OR=1.987, 95% CI=1.438-2.746, p=0.000). In addition, there was association between CML and the null type of the combination GSTM1-GSTT1 polymorphisms (OR=4.191, 95% CI=2.833-6.201, p=0.000). Thus, genetic polymorphisms of the GSTM1, GSTT1 and combination GSTM1-GSTT1 polymorphism in Asian populations may be risk factors for CML.
Keywords
Chronic Myeloid Leukemia; Meta-analysis; Glutathione S-transferase; Gene Polymorphism;
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