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http://dx.doi.org/10.5392/JKCA.2012.12.02.348

Extract of Listeria monocytogenes Induces the Apoptosis on the Human Promyelocytic Leukemia Cells, HL-60 Cells  

Yang, Eun-Ju (대구한의대학교 보건치료대학 임상병리학과)
Kim, Dong-Hyun (부산가톨릭대학교 보건과학대학 방사선학과)
Chang, Jeong-Hyun (대구한의대학교 보건치료대학 임상병리학과)
Publication Information
The Journal of the Korea Contents Association / v.12, no.2, 2012 , pp. 339-348 More about this Journal
Abstract
Acute promyelocytic leukemia (APL) is a cancer of the blood and bone marrow. Although all-trans retionic acid (ATRA) is the agents for ALP therapy, there are various side effects. For overcome this problem, we need the development of new therapeutic agents for APL. A number of bacteria produce various virulence factors with cytotoxic effects on human cancer cells. To understand the anti-cancer effect of Listeria monocytogenes on APL, we examined alteration of the cell viability, apoptosis and cell cycle arrest of the human promyelocytic leukemia cell line, HL-60 cells. The cell supernatant (LmSup) and the extract of L. monocytogenes (LmE) inhibited the cell viability and induced apoptosis of HL-60 cells. These cytotoxic effect of LmSup and LmE mediated by modulation of cell cycle and ROS production. These results indicate that released or included bacterial molecules from L. monocytogenes have a cytotoxicity in HL-60 cells. Therefore, LmSup and LmE may be used as the potential target for the treatment of cancer induced by HL-60 cells.
Keywords
Listeria monocytogenes; HL-60 cells; Apoptosis; ROS; Anti-cancer Effect;
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