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http://dx.doi.org/10.5392/JKCA.2011.11.10.342

Validity of Ultrasonography in the Diagnosis of Non-alcoholic Fatty Liver Disease in Living Liver Donors  

Kim, Yon-Min (삼성서울병원 영상의학과)
Han, Dong-Kyoon (을지대학교 보건과학대학 방사선학과)
Publication Information
The Journal of the Korea Contents Association / v.11, no.10, 2011 , pp. 342-348 More about this Journal
Abstract
The study aimed to compare the validity between the abdominal ultrasonographic(US) grading system of fatty liver and histologic grading system of fatty liver in living liver donor candidates. As the fatty liver is defined as pathologic total fat >10%, US validity was sensitivity 64.6%, specificity 68%, positive predictive value 76.8%, negative predictive value 54%. As the strict data handling on US grading normal, mild fatty liver are negative, moderate fatty liver is positive, US validity was sensitivity 26.8%, specificity 100%, positive predictive value 100%, negative predictive value 45.5%. ROC curve analysis according to different cut off value of liver-to-kidney brightness ratio was Area under ROC curve=0.859(95% CI=0.795~0.922, state variable= total fat 10%). There were statistically significant difference( p<0.001). Ultrasonography for the fatty diagnosis showed a high validity to predict the result of histology grade of fatty liver.
Keywords
Abdominal ultrasonography; Fatty liver; Liver biopsy;
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Times Cited By KSCI : 5  (Citation Analysis)
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1 T. H. Kim and k. Yoo, "Obesity and fatty liver disease," Kor J Med, Vol.68, No.4, pp.347-349, 2005.
2 T. S. Church, J. L. Kuk, and R. Ross, "Association of cardiorespiratory fitness, body mass index and waist circumference to NAFLD," Gastroentero, Vol.130, No.7, pp.2023-2030, 2006.   DOI   ScienceOn
3 Sherif Saadeh, "The Utility of Radiological imageing in Nonalcoholic Fatty Liver Disease," Gastroenterology Vol.123, No.3, pp.745-750, 2002.   DOI   ScienceOn
4 A. Yoshiakyi, K. Jima, Ei Qhta, Takashni Arui, and B. Ryuzoa. Ultrasonographical Significance of the Diagnosis of Fatty Liver:Liver-Kidney Contrast. Tohoku J. exp. Med. Vol.139, No.1, pp.43-50, 1983.   DOI
5 L. A. Adams, P. Angulo, K. D. Lindor, "Nonalcoholic fatty liver disease," CMAJ, Vol.172, No.7, pp.899-905, 2005.   DOI   ScienceOn
6 L .M. Alba, K. Lindor, "Nonalcoholic fatty liver disease," Aliment Pharmacol Ther, Vol.17, No.8, pp.977-986, 2003.   DOI   ScienceOn
7 정의경, 강영한, 박재용, "남성 건강검진 수진자들에서 알코올성 및 비알코올성 지방간과 대시증후군과의 관련성", 한국콘텐츠학회논문지, 제9권, 제6호, pp.237-246, 2009.
8 윤중원, 조용균, "비알코올성 지방간이 다른 내과질환에 미치는 임상적 영향", 대한내과학회지, 제76권, 제1호, pp.25-29, 2009.   과학기술학회마을
9 이미연, 정홍량, 임청환, "건강검진 초음파에서 지역별 간질환 유병률 비교 분석", 한국콘텐츠학회논문지, 제9권, 제3호, pp.278-287, 2009.   과학기술학회마을   DOI   ScienceOn
10 박승하, 김병익, 유태우, "건강검진 수진자에서 비알콜성 지방간 및 간기능 장애: 인슐린 저항성과의 관계", 대한소화기학회지, 제41권, 제5호, pp.366-373, 2003.
11 박중원, 유병철, "비알콜성 지방간의 진행: 지질과산화,미토콘드리아 장애 및 싸이토카인의 역할", 대한소화기학회지, 제38권, 제1호, pp.1-8, 2001.
12 J. C. Scatarige, W. W. Scott, and P. J. Donovanl, "Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation," J Ultrasound Med, Vol.3, No.1, pp.9-14, 1984.   DOI
13 M. Freese and E. A. Lyons, "Ultrasonic backscatter from human liver tissue: its dependence on frequency and protein/lipid composition," J Clin Ultrasound, Vol.5, No.5, pp.307-312, 1977.   DOI   ScienceOn
14 S. M. Strasberg, T. K. Howard, E. P. Molmenti, and M. Hertl, "Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation," Hepatology, Vol.20, No.4, pp.829-838, 1994.   DOI   ScienceOn
15 조용균, "복부비만을 가진 한국인의 내장지방세포에서 Adipokine 발현이 비알코올지방간질환의 진행정도에 미치는 영향", 대한간학회지, 제14권, 제5호, pp.81-85, 2008.
16 박헌진, 안정기, 강원권, "지방간의 임상적 고찰", 대한소화기병학회지, 제21권, 제1호, pp.96-103, 1989.
17 A. J. McCullough, "Update on nonalcoholic fatty liver disease," J Clin Gastroenterol, Vol.34, No.3, pp.255-262, 2002.   DOI   ScienceOn
18 P. Angulo, "Nonalcoholic fatty liver disease," N Engl J Med, Vol.346, No.16, pp.1221-1231, 2002.   DOI   ScienceOn