Styrene Cytotoxicity in Testicular Leydig Cells In Vitro |
Chung, Jin-Yong
(Department of Anatomy and Cell Biology, College of Medicine, Dong-A University)
Park, Ji-Eun (Department of Anatomy and Cell Biology, College of Medicine, Dong-A University) Kim, Yoon-Jae (Department of Anatomy and Cell Biology, College of Medicine, Dong-A University) Lee, Seung-Jin (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) Yu, Wook-Joon (Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology) Kim, Jong-Min (Department of Anatomy and Cell Biology, College of Medicine, Dong-A University) |
1 | Abdel-Maksoud FM, Ali FAZ, Akingbemi BT (2019) Prenatal exposures to bisphenol A and di (2-ethylhexyl) phthalate disrupted seminiferous tubular development in growing male rats. Reprod Toxicol 88:85-90. DOI |
2 | Chung JY, Kim YJ, Kim JY, Lee SG, Park JE, Kim WR, Yoon YD, Yoo KS, Yoo YH, Kim JM (2011) Benzo[a]pyrene reduces testosterone production in rat Leydig cells via a direct disturbance of testicular steroidogenic machinery. Environ Health Perspect 119:1569-1574. DOI |
3 | Dare E, Tofighi R, Nutt L, Vettori MV, Emgard M, Mutti A, Ceccatelli S (2004) Styrene 7,8-oxide induces mitochondrial damage and oxidative stress in neurons. Toxicology 201:125-132. DOI |
4 | Negri C, Bernardi R, Donzelli M, Prosperi E, Scovassi AI (1996) Sequence of events leading to apoptosis in long term cultured HeLa cells. Cell Death Differ 3:425-430. |
5 | Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99-104. DOI |
6 | Sliwinska-Kowalska M, Fuente A, Zamyslowska-Szmytke E (2020) Cochlear dysfunction is associated with styrene exposure in humans. PLoS One 5:e0227978. DOI |
7 | Traore K, Martinez-Arguelles DB, Papadopoulos V, Chen H, Zirkin BR (2016) Repeated exposures of the male Sprague Dawley rat reproductive tract to environmental toxicants: Do earlier exposures to di-(2-ethylhexyl)phthalate (DEHP) alter the effects of later exposures? Reprod Toxicol 61:136-141. DOI |
8 | Venkatachalam S, Denissenko MF, Alvi N, Wani AA (1993) Rapid activation of apoptosis in human promyelocytic leukemic cells by (+/-)-anti-benzo[a]pyrene diol epoxide induced DNA damage. Biochem Biophys Res Commun 197:722-729. DOI |
9 | Zirkin BR (1998) Spermatogenesis: Its regulation by testosterone and FSH. Semin Cell Dev Biol 9:417-42. DOI |
10 | Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP (2004) Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145:592-603. DOI |
11 | Chung JY, Kim JY, Kim YJ, Jung SJ, Park JE, Lee SG, Kim JT, Oh S, Lee CJ, Yoon YD, Yoo YH, Kim JM (2007) Cellular defense mechanisms against benzo[a]pyrene in testicular Leydig cells: Implications of p53, aryl-hydrocarbon receptor, and cytochrome P450 1A1 status. Endocrinology 148:6134-6144. DOI |
12 | Corsi P, D'Aprile A, Nico B, Costa GL, Assennato G (2007) Synaptic contacts impaired by styrene-7,8-oxide toxicity. Toxicol Appl Pharmacol 224:49-59. DOI |
13 | Cruzan G, Carlson GP, Johnson KA, Andrews LS, Banton MI, Bevan C, Cushman JR (2002) Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites. Regul Toxicol Pharmacol 35:308-319. DOI |
14 | Gong YY, Kishi R, Katakura Y, Tsukishima E, Fujiwara K, Kasai S, Satoh T, Sata F, Kawai T (2002) Relation between colour vision loss and occupational styrene exposure level. Occup Environ Med 59:824-829. DOI |
15 | Gopal KV, Wu C, Moore EJ, Gross GW (2011) Assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks. ISRN Otolaryngol 2011:204804. |
16 | Moujahed S, Ruiz A, Hallegue D, Sakly M (2022) Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons in vitro via modulation of oxidative stress and apoptosis. Drug Chem Toxicol 45:1634-1643. DOI |
17 | Guengerich FP, Kim DH, Iwasaki M (1991) Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4:168-179. DOI |
18 | Liston P, Fong WG, Korneluk RG (2003) The inhibitors of apoptosis: There is more to life than Bcl2. Oncogene 22:8568-8580. DOI |
19 | Moller C, Odkvist L, Larsby B, Tham R, Ledin T, Bergholtz L (1990) Otoneurological findings in workers exposed to styrene. Scand J Work Environ Health 16:189-194. DOI |
![]() |