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http://dx.doi.org/10.12717/DR.2018.22.2.119

Evolutionary Viewpoint on GnRH (gonadotropin-releasing hormone) in Chordata - Amino Acid and Nucleic Acid Sequences  

Choi, Donchan (Dept. of Life Science, College of Environmental Sciences, Yong-In University)
Publication Information
Development and Reproduction / v.22, no.2, 2018 , pp. 119-132 More about this Journal
Abstract
GnRH (gonadotropin-releasing hormone) is a supreme hormone regulating reproductive activity in most animals. The sequences of amino acid and nucleic acid of GnRH reported up to now are examined from the evolutionary framework of Chordata. All identified GnRH are classified into GnRH1, GnRH2, or GnRH3. In all three forms of GnRH both N-terminal and C-terminal are conserved, which allows for effective binding to their receptors. The three amino acids in the middle of GnRH1 sequence have altered diversely from the primitive Chordata, which is indicative of the adaptation process to the ambient environment. GnRH2 and GnRH3 sequences are well conserved. There are more diverse modifications in the nucleic acids than in amino acid sequence of GnRH1. These variations can result from meiosis, mutation, or epigenetics and indicate that GnRH is the product of natural selection.
Keywords
GnRH (gonadotropin-releasing hormone); Evolution; Chordata; Amino acid; Nucleic acid;
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1 Mason AJ, Hayflick JS, Zoeller RT, Young III 3rd WS, Phillips HS, Nikolics K, Seeberg PH (1986) A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234:1366-1371.   DOI
2 Matsuo H, Baba Y, Nair RMG, Arimura A, Schally AV (1971) Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun 43:1334-1339.   DOI
3 McNew SM, Beck D, Sadler-Riggleman I, Knutie SA, Koop JAH, Clayton DH, Skinner MK (2017) Epigenetic variation between urban and rural populations of Darwin's finches. BMC Evol Biol 17:183.   DOI
4 Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR (2004) Gonadotropin-releasing hormone receptors. Endocr Rev 25:235-275.
5 Millar RP (2005) GnRHs and GnRH receptors. Anim Reprod Sci 88:5-28.   DOI
6 Miyamoto K, Hasegawa Y, Nomura M, Igarashi M, Kangawa K, Matsuo H (1984) Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: Evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species. Proc Natl Acad Sci USA 81:3874-3878.   DOI
7 Mohamed JS, Khan IA (2006) Molecular cloning and differential expression of three GnRH mRNAs in discrete brain areas and lymphocytes in red drum. J Endocrinol 188:407-416.   DOI
8 Mohamed JS, Thomas P, Khan IA (2005) Isolation, cloning, and expression of three prepro-GnRH mRNAs in Atlantic croaker brain and pituitary. J Comp Neurol 488:384-395.   DOI
9 Muske LE, King JA, Moore FL, Millar RP (1994) Gonadotropin-releasing hormones in microdissected brain regions of an amphibian: Concentration and anatomical distribution of immunoreactive mammalian GnRH and chicken GnRH II. Regul Pept 54:373-384.   DOI
10 Mongiat LA, Fernandez MO, Lux-Lantos VAR, Guilgur LG, Somoza GM, Libertun C (2006) Experimental data supporting the expression of the highly conserved GnRH-II in the brain and pituitary gland of rats. Regul Pept 136:50-57.   DOI
11 Ogawa S, Akiyama G, Kato S, Soga T, Sakuma Y, Parhar IS (2006) Immunoneutralization of gonadotropinreleasing hormone type-III suppresses male reproductive behavior of cichlids. Neurosci Lett 403:201-205.   DOI
12 Roch GJ, Busby ER, Sherwood NM (2011) Evolution of GnRH: Diving deeper. Gen Comp Endocrinol 171:1-16.   DOI
13 Roch GJ, Tello JA, Sherwood NM (2014) At the transition from invertebrates to vertebrate, a novel GnRH-like peptide emerges in amphioxus. Mol Biol Evol 31:765-778.   DOI
14 Sakai T, Shiraishi A, Kawada T, Matsubara S, Aoyama M, Satake H (2017) Invertebrate gonadotropin-releasing hormone-related peptides and their receptors: An update. Front Endocrinol 8:217.   DOI
15 Schally AV, Arimura A, Baba Y, Nair RMG, Matsuo H, Redding TW, Debeljuk L, White WF (1971) Isolation and properties of the FSH and LH-releasing hormone. Biochem Biophys Res Commun 43:393-399.   DOI
16 Schally AV, Block NL, Rick FG (2017) Discovery of LHRH and development of LHRH analogs for prostate cancer treatment. Prostate 77:1036-1054.   DOI
17 Steven C, Lehnen N, Kight K, Ijiri S, Klenke U, Harris WA, Zohar Y (2003) Molecular characterization of the GnRH system in zebrafish (Danio rerio): Cloning of chicken GnRH-II, adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRHII. Gen Comp Endocrinol 133:27-37.   DOI
18 Schwanzel-Fukuda M, Bick D, Pfaff DW (1989) Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol Brain Res 6:311-326.   DOI
19 Skinner MK, Guerrero-Bosagna C, Haque MM, Nilsson EE, Koop JAH, Knutie SA, Clayton DH (2014) Epigenetics and the evolution of Darwin's finches. Genome Biol Ecol 6:1972-1989.   DOI
20 Sower SA, Chiang YC, Lovas S, Conlon JM (1993) Primary structure and biological activity of a third gonadotropin-releasing hormone from lamprey brain. Endocrinology 132:1125-1131.   DOI
21 Temple JL, Millar RP, Rissman EF (2003) An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior. Endocrinology 144:13-19.   DOI
22 Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, Kikuchi M, Ishii S, Sharp PJ (2000) A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275:661-667.   DOI
23 Tsutsui K, Osugi T, Son YL, Ubuka T (2017) Review: Structure, function and evolution of GnIH. Gen Comp Endocrinol 17:30314-30323.
24 Volkoff H, Peter RE (1999) Actions of two forms of gonadotropin releasing hormone and a GnRH antagonist on spawning behavior of the golden fish Carassius auratus. Gen Comp Endocrinol 116:347-355.   DOI
25 Carroll RS, Corrigan AZ, Gharib SD, Vale W, Chin WW (1989) Inhibin, activin, and follistatin: Regulation of follicle-stimulating-hormone messenger ribonucleic acid levels. Mol Endocrinol 3:1969-1976.   DOI
26 Weiss J, Crowley WF, Halvorson LM, Jameson JL (1993) Perifusion of rat pituitary cells with gonadotropinreleasing hormone, activin, and inhibin reveals distinct effects on gonadotropin gene expression and secretion. Endocrinology 132:2307-2311.   DOI
27 White RB, Fernald RD (1998) Ontogeny of gonadotropinreleasing hormone (GnRH) gene expression reveals a distinct origin for GnRH-containing neurons in the midbrain. Gen Comp Endocrinol 112:322-329.   DOI
28 Amano M, Okubo K, Ikuta K, Kitamura S, Okuzawa K, Yamada H, Aida K, Yamamori K (2002) Ontogenic origin of salmon GnRH neurons in the ventral telencephalon and the preoptic area in masu salmon. Gen Comp Endocrinol 127:256-262.   DOI
29 Baba Y, Matsuo H, Schally AV (1971) Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses. Biochem Biophys Res Commun 44:459-463.   DOI
30 Ben Maamar M, Sadler-Riggleman I, Beck D, Skinner MK (2018) Epigenetic transgenerational inheritance of altered sperm histone retention sites. Sci Rep 8:5308.   DOI
31 Charlton HM, Halpin DMG, Iddon C, Rosie R, Levy G, McDowell IFW, Megson A, Morris JF, Bramwell A, Speight A, Ward BJ, Broadhead J, Davey-Smith G, Fink G (1983) The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse. Endocrinology 113:535-544.   DOI
32 Chen CC, Fernald RD (2008) GnRH and GnRH receptors: Distribution, function and evolution. J Fish Biol 73:1099-1120.   DOI
33 Darwin C (1839) Chapter XIX. In: Narrative of the Surveying VOyages of His Majesty's Ships Adventure and Beagle, between the Years 1826 and 1836, Describing their Examination of the Southern Shores of South America, and the Beagle's Circumnavigation of the Globe. Vol III. Henry Colburn, Great Marlborough Street. London. pp 453-478.
34 Chiba A, Sohn YC, Honma Y (1996) Immunohistochemical and ultrastructural characterization of the terminal nerve ganglion cells of the ayu, Plecoglossus altivelis (Salmoniformes, Teleostei). Anat Rec 246:549-556.   DOI
35 Choi D, Lee SH. (2012) Neuroendocrine system in seasonal breeder: Focusing on the reproductive activity of male golden hamster. Dev Reprod 16:1-8.
36 Dardente H, Lomet D, Robert V, Decourt C, Beltramo M, Pellicer-Rubio MT (2016) Seasonal breeding in mammals: From basic science to applications and back. Theriogenology 86:324-332.   DOI
37 Darwin C (1859) Geographical distribution. In: On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. John Murray, Albemarle Street. London. pp 383-410.
38 Darwin C (1891) Galapagos archipelago. In: Geological Observation on the Volcanic Islands and Parts of South America Visited during the Voyage of H.M.S. 'Beagle'. 3rd ed. D. Appleton and Company. New York. pp 110-131.
39 Desaulniers AT, Cederberg RA, Lents CA, White BR (2017) Expression and role of gonadotropin-releasing hormone 2 and its receptor in mammals. Front Endocrinol 8:269.   DOI
40 Felsenfeld G (2014) The evolution of epigenetics. Perspect Biol Med 57:132-148.   DOI
41 Flanagan CA, Manilall A (2017) Gonadotropin-releasing hormone (GnRH) receptor structure and GnRH binding. Front Endocrinol 8:274.   DOI
42 Hasunuma I, Terakado K (2013) Two novel gonadotropinreleasing hormones (GnRHs) from urochordate Ascidian, Halocynthia roretzi: Implication for the origin of vertebrate GnRH isoforms. Zool Sci 30:311-318.   DOI
43 Gonzalez-Martinez D, Zmora N, Mananos E, Saligaut D, Zanuy S, Zohar Y, Elizur A, Kah O, Munoz-Cueto JA (2002) Immunohistochemical localization of three different prepro-GnRHs in the brain and pituitary of the European sea bass (Dicentrarchus labrax) using antibodies to the corresponding GnRH-associated peptides. J Comp Neurol 446:95-113.   DOI
44 Grens KE, Greenwood AK, Fernald RD (2005) Two visual processing pathways are targeted by gonadotropin-releasing hormone in the retina. Brain Behav Evol 66:1-9.   DOI
45 Guerrero-Bosagna C, Settles M, Lucker B, Skinner MK (2010) Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One 5:e13100.   DOI
46 Jirtle RL, Skinner MK (2007) Environmental epigenomics and disease susceptibility. Nat Rev Genet 8:253-262.   DOI
47 Kakizawa S, Kaneko T, Hirano T (1997) Effects of hypothalamic factors on somatolactin secretion from the organ-cultured pituitary of rainbow trout. Gen Comp Endocrinol 105:71-78.   DOI
48 Karigo T, Oka Y (2013) Neurobiological study of fish brains gives insights into the nature of gonadotropinreleasing hormone 1-3 neurons. Front Endocrinol 4:177.
49 Kauffman AS, Rissman EF (2004) A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: Mediation of energy status and female sexual behavior. Endocrinology 145:3639-3646.   DOI
50 Kauffman AS, Wills A, Millar RP, Rissman EF (2005) Evidence that the type-2 gonadotrophin-releasing hormone (GnRH) receptor mediates the behavioural effects of GnRH-II on feeding and reproduction in musk shrews. J Neuroendo 17:489-497.   DOI
51 Maney DL, Richardson RD, Wingfield JC (1997) Central administration of chicken gonadotropin-releasing hormone-II enhances courtship behavior in a female sparrow. Horm Behav 32:11-18.   DOI
52 Marchant TA, Chang JP, Nahorniak CS, Peter RE (1989) Evidence that gonadotropin-releasing hormone also functions as a growth hormone-releasing factor in the goldfish. Endocrinology 124:2509-2518.   DOI