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http://dx.doi.org/10.7742/jksr.2021.15.4.539

Evaluation the Effectiveness of Fibrinogen to Overcome Bone Radiation Damage  

Jung, Hong-Moon (Department of Radiological Science, Daegu Health College)
Publication Information
Journal of the Korean Society of Radiology / v.15, no.4, 2021 , pp. 539-545 More about this Journal
Abstract
Radiation therapy is accompanied by adverse radiation effective. In particular, it is accompanied by disorders of the vascular system. Therefore, oxygen and nutrient deficiency occurs in the regeneration area. Eventually, osteoradionecrosis is formed in this cellular environment. According to a precedent study, bone morphogenetic protein-2 is used to overcome osteoradionecrosis. The purpose of this study was to investigate the regeneration ability of osteoradionecrosis by treating bone-forming protein-2 on a fibrinogen scaffold which is a biomaterial that is frequently used for bone regeneration after irradiation of the rat head. In addition, the purpose of this study was to verify the bone regeneration effect from the eight weeks. According to the experimental results, in the calvarial defected model of the irradiated mouse, making bone-formation was obtained after 8 weeks rather than bone-formation period in the early 4 weeks. moreover, it was found that the regenerated bone formation of the fibrinogen scaffold is formed from the inside of the bone of the defect area.
Keywords
bone morphogenic protein-2; fibrinogen scaffold; osteoradionecrosis;
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