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http://dx.doi.org/10.7742/jksr.2021.15.2.229

Selective Permeate Transport Characteristics of Iodine ion at Cell Membrane Model of Thyroid which Irradiated by High Energy X-Ray  

Ko, In-Ho (Department of Radiological Technology, Cheju Halla University)
Yeo, Jin-Dong (Department of Radiological Technology, Sarabol University)
Publication Information
Journal of the Korean Society of Radiology / v.15, no.2, 2021 , pp. 229-238 More about this Journal
Abstract
The selective permeate transport characteristics of iodine ion at follicle cell membrane model in thyroid which irradiated by high energy x-ray(linac 6 MV) was investigated. The follicle cell membrane model used in this experiment was a polysulfonated copolymerized membrane of poly(4-vinylpyridine-co-acrylonitrile:VP-AN). The difference of membrane thickness [2 mole AN%(w/w)], fixed carrier concentration[VP-AN%(w/w)], OH- concentration were occurred at difference of I- concentration and quantity of thyroid hormone, respectively. The tensile strength in fixed carrier concentration[VP-AN% (w/w): 0-62 %] of irradiated membrane was found to be decreased about 1.2-1.8 times than non-irradiated membrane. The I- selective permeate initial flux with increase of membrane thickness [2mole AN%(w/w)], fixed carrier concentration[VP-AN%(w/ w)], OH- concentration in irradiated membrane were found to be decreased about 2.1-4.5 times, about 2.2-2.5 times, about 2.1-2.67 times than non-irradiated membrane, respectively. As a result, the quantity of thyroid hormone was decreased at irradiated membrane than non-irradiated membrane. The decrease of thyroid hormone was occurred at hypothyroidism and hyperthyroidism, thyroid cancer, and so on. As the thyroid hormone in cell membrane model were abnormal, cell damages were appeared at cell.
Keywords
high energy x-ray; fixed carrier concentration[VP-AN%(w/ w)]; sulfonated copolymerized membrane(4-VP-AN);
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1 P. M. Bungay, Synthetic Polymer Membranes: Science Engineering and Application, 2nd Ed., D. Reidal Publishing Company., New York, pp. 234-236, 1985.
2 H. Brockman, "Dipole potential of lipid membrane", Chemical Physics of Lipids, Vol. 73, No. 3, pp. 57-79, 1994.   DOI
3 S. H. Lee, Y. C. Lee, "Ultrafiltration Characteristics of Poly(vinyl Alcohol) Solution and Theoretical Investigations", Journal of Membrane Science, Vol. 6, No. 4, pp. 203-212, 1996.
4 T. Shimidzu, N. Yoshikawa, M. Hsegawa, K. Kasakatus, "Active transport and selectivity transport of akalimetal ion through poly(3-vinyl-1, 4-butyrolaction-co-acrylonitrile) membrane", macromolecules, Vol. 14, No. 1, pp. 170, 1981.   DOI
5 M. K. Jeong, S. Y. Nam, "Preparation and characterization of organic solvent-resistant polybenzimidazole on membranes", Applied Chemical Engineering, Vol. 28, No. 4, pp. 420-426, 2017. http://dx.doi.org/http://dx.doi.org/10.14478/ace.2017.1015   DOI
6 H. Fugita, A. Kishimoto, K. Matsumoto, "Characteristics of moving molecular in membrane", Translation Faraday Society, Vol. 56, No. 6, pp. 424, 1960.   DOI
7 T. Uragami, S. Watanabe, R. Nakamura, F. Yoshida, M. Sugihara, "study on synthesis and Fermeabilities of polymer Membrane", Journal of Application polymer Science, Vol. 28, No. 3, pp. 1613. 1981.
8 H. K. Byun, Y. J. Jeon, S. K. Kim, "Characteristics on the permeation of protein through membrane of ultrafiltration reactor", Journal of Membrane Science, Vol. 8, No. 1, pp. 42-49, 1998.
9 I. H. Ko, J. D. Yeo, "Separation Permeation Characteristics of N2-O2 Gas in Air at Cell Membrane Model of Skin which Irradiated by High Energy Electron", Journal of Korean Society of Radiology, Vol. 13, No. 2, pp. 261-270, 2019. http://dx.doi.org/10.7742/jksr.2019.13.2.261   DOI
10 R. E. Kesting, Synthetic Polymer Membranes, 1st Ed., McGraw Hill Co., New York, pp. 87-88, 1977.
11 I. H. Ko, J. D. Yeo, "Active Transport Characteristics of Anions through a Cell Membrane Model which Irradiated by r-ray", Journal of Korean Society of Radiology, Vol. 9, No. 4, pp. 187-195, 2015.   DOI
12 H. J. Kim, K. H. Jin, M. K. Ryu, I. T. S. Seo, "Normal range measurement of thyroid hormone in Radioimmunoassay(RIA)", Korean Journal of Clinical Laboratory, Vol. 24, No. 1, pp. 77-81, 1992.
13 K. W. Kang, "Radioiodine therapy in distant metastasis of differentiated thyroid cancer", International Journal of Thyroidology, Vol. 6, No. 1, pp. 49-55, 2013.
14 S. W. Cho, Y. J. Jin, M. K. Park, "Monogenic disorders of thyroid", International Journal of thyroidology, Vol. 5, No. 2, pp. 83-93, 2012.
15 M. E. McGuinness, R. L. Talbert, "Management of thyroid disorders", American Pharmacy, Vol. 34, No. 1, pp. 36-47, 1992.   DOI
16 M. J. Reinhardt, E. Moser, "An update on diagnostic methods in the investigation of diseases of the thyroid", European Journal of Nuclear Medicine, Vol. 23, No. 5, pp. 587-594, 1996. http://dx.doi.org/10.1007/BF00833398   DOI
17 G. G. Klee, I. D. Hay, "Biochemical testing of thyroid function", Endocrinology and Metabolism Clinics of North American, Vol. 26, No. 1, pp. 763-775, 1997. http://dx.doi.org/10.1016/S0889-8529(05)70281-4   DOI