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http://dx.doi.org/10.7742/jksr.2019.13.5.811

Efficiency Evaluation of Irradiated on Mouse Calvarial Model by BMP-2  

Jung, Hongmoon (Department of Radiological Science, Daegu Health College)
Publication Information
Journal of the Korean Society of Radiology / v.13, no.5, 2019 , pp. 811-817 More about this Journal
Abstract
Radiation-therapy causes the adverse radiation effect. It is called osteoradionecrosis. A protein-therapy is carried out in order to cure osteoradionecrosis. The typical method of the protein-therapy is using BMP-2. Considering to bone damage, it is more important that maintains enough to circumstance regeneration for osteoblast differentiation on damage site of bone. Thus, this study is on a tissue regeneration to cure radiation critical damage. I observed that the formation of new regeneration bone by injection of collagen sheet BMP-2 on irradiated mouse. Consequently, I examined new bone formation with collagen sheet BMP-2 on irradiated mouse after 8weeks. Therefore I suggested that using collagen sheet BMP-2 which can be good for new bone regeneration effect on radiation side effect area.
Keywords
irradiated mouse head; radiation bone damage; bone morphogenic protein-2; osteoradionecrosis;
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