Browse > Article
http://dx.doi.org/10.7742/jksr.2019.13.4.539

Consideration of Cut-off Value for Fibrosis Serum Marker by Liver Fibrosis Stage in Chronic Hepatitis C Patients  

Nam, Ji-Hee (Department of Radiology of Busan Paik Hospital)
Kim, Jung-Hoon (Department of Radiological Science, Catholic University of Pusan)
Publication Information
Journal of the Korean Society of Radiology / v.13, no.4, 2019 , pp. 539-546 More about this Journal
Abstract
Liver biopsy is invasive and it is a risk of complications. Nevertheless, liver biopsy is gold standard for predicting liver fibrosis. To compensate for these shortcomings, in this study, the liver fibrosis stage was divided using Fibroscan(R) in 200 chronic hepatitis C patients. And, the usefulness and cut-off values of fibrosis index based on four factors(FIB-4), AST to platelet ratio index(APRI) and AST/ALT ratio(AAR) calculated as serum tests were investigated by analyzing ROC curve. As a result, using FIB-4 and APRI rather than AAR is appropriate for evaluation of liver fibrosis. And using APRI to predict significant Fibrosis(F2) and FIB-4 is considered useful for predicting cirrhosis(F4). By applying the advantages of the serum based liver fibrosis marker, which are convenient and repeatable, liver fibrosis follow-up term can be reduced, and furthermore, the prevalence of liver cirrhosis and hepatocellular carcinoma(HCC) can be reduced.
Keywords
Liver Fibrosis; Fibroscan; FIB-4(Fibrosis index debased on four factors); APRI(AST to platelet ratio index); AAR(AST/ALT ratio);
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 L. Sandrin, B. Fourquet, J. M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Medicine & Biology, Vol. 29, No. 12, pp. 1705-1713, 2003.   DOI
2 J. Foucher, L. Castera,P. H. Bernard, X. Adhoute, D. Laharie, J. Bertet, P. Couzigou, V. de Ledinghen, “Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations,” European Journal of Gastroenterology & Hepatology, Vol. 18, No. 4, pp. 411-412, 2006.   DOI
3 A. Berzigotti, E. Ashkenazi, E. Reverter, J. G. Abraldes, J. Bosch, “Non-invasive diagnostic and prognostic evaluation of liver cirrhosis and portal hypertension,” Disease Markers, Vol. 31, No. 3, pp. 129-138, 2011.   DOI
4 M. J. Andres-Otero, I. De-Blas-Giral, J. J. Puente-Lanzarote, T. Serrano-Aullo, M. J. Morandeira, S. Lorente, J. M. Lou-Bonafonte, “Multiple approaches to assess fourteen non-invasive serum indexes for the diagnosis of liver fibrosis in chronic hepatitis C patients,” Clinical Biochemistry, Vol. 49, No. 7-8, pp. 560-565, 2016.   DOI
5 R. K. Sterling, E. Lissen, N. Clumeck, R. Sola, M. C. Correa, J. Montaner, S. Sulkowski M, F. J. Torriani, D. T. Dieterich, D. L. Thomas, D. Messinger, M. Nelson, “Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection,” Journal of Hepatology, Vol. 43, No. 6, pp. 1317-1325, 2006.   DOI
6 S. M. Kim, J. H. Sohn, T. Y. Kim, Y. W. Roh, C. S. Eun, Y. C. Jeon, D. S. Han, Y. H. Oh, “Comparison of various noninvasive serum markers of liver fibrosis in chronic viral liver disease,” The Korean Journal of Hepatology, Vol. 15, No. 4, pp. 454-463, 2009.   DOI
7 H. S. Sim, Ultrasonography Anatomy & Scan Technique, 3rd Ed., Hanmi Publishing Co., Korea, pp. 137, 2016.
8 C. T. Wai, J. K. Greenson, R. J. Fontana, J. D. Kalbfleisch, J. A. Marrero, H. S. Conjeevaram, A. S. Lok, “A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C,” Journal of hepatology, Vol. 38, No. 2, pp. 518-526, 2003.
9 S. H. Jeong, E. S. Jang, H. Y. Choi, K. A. Kim, W. Chung, M. Ki, "Current Status of Hepatitis C Virus Infection and Countermeasures in South Korea," Epidemiology and Health, Vol. 39, 2017PMC5543292, 2017.
10 C. C. Wang, C. H. Liu, C. L. Lin, P. C. Wang, T. C. Tseng, H. H. Lin, J. H. Kao, “Fibrosis index based on four factors better predicts advanced fibrosis or cirrhosis than aspartate aminotransferase/platelet ratio index in chronic hepatitis C patients,” Journal of the Formosan Medical Association, Vol. 114, No. 10, pp. 923-928, 2015.   DOI
11 F. Piccinino, E. Sagnelli, G. Pasquale, G. Giusti, “Complications following percutaneous liver biopsy, A multicentre retrospective study on 68,276 biopsies,” Journal of hepatology, Vol. 2, No. 2, pp. 165-173, 1986.   DOI
12 A. Regev, M. Berho, L. J. Jeffers, C. Milikowski, E. G. Molina, “Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection,” American Journal of Gastroenterology, Vol. 97, No. 10, pp. 2614-2618, 2002.   DOI
13 M. Ziol, A. Handra-Luca, A. Kettaneh, C. Christidis, F. Mal, F. Kazemi, V. de Ledinghen, P. Marcellin, D. Dhumeaux, J. C. Trinchet, M. Beaugrand, “Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C,” Journal of Hepatology, Vol. 41, No. 1, pp. 48-54, 2005.   DOI
14 L. Castera, J. Vergniol, J. Foucher, B. Le Bail, E. Chanteloup, M. Haaser, M. Darriet, P. Couzigou, V. De Ledinghen, "Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C," Journal of Gastroenterology, Vol 128, No. 2. pp. 343-350, 2005.   DOI
15 C. Colletta, C. Smirne, C. Fabris, P. Toniutto, R. Rapetti, R. Minisini, M. Pirisi, "Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases," Journal of Hepatology, Vol. 42, No. 4, pp. 838-845 2005.   DOI
16 L. Castera, X. Forns, A. Alberti, “Non-invasive evaluation of liver fibrosis using transient elastography,” Journal of Hepatology, Vol. 48, No. 5, pp. 835-847, 2008.   DOI