Browse > Article
http://dx.doi.org/10.7742/jksr.2019.13.2.283

A Study for possibility of Diagnostic Indicators by measuring the Fingertip Temperature after Cooling Load in Raynaud's Patients  

Chang, Ho-Suk (Department of Nuclear Medicine, Uijeongbu st. Mary's Hospital, The Catholic University of Korea)
Heo, Yeong-Cheol (Department of Radiological science, College of Health sciences, Eulji University)
Publication Information
Journal of the Korean Society of Radiology / v.13, no.2, 2019 , pp. 283-290 More about this Journal
Abstract
The purpose of this study is to suggest a quantitative supplementary index for patients with suspected Raynaud phenomenon. The subjects were 99 patients with suspected Raynaud phenomenon, 48 patients with low likelihood, 16 patients with middle range and 35 patients with high range. The test was instilled in ice water at $15.2{\pm}0.8^{\circ}C$ for 10 minutes of both hands and then venous injected of 99m-Tc 370 Mbq(10 mCi). After 5, 10 and 20 minutes, temperature changes of both fingers were measured. As a result, the temperature of the fingers was $32.6{\pm}4.9^{\circ}C$ in patients with a low diagnostic probability of Raynaud syndromes and $22.7{\pm}6.0^{\circ}C$ for those with a high diagnostic probability(p<0.05). In conclusion, we could confirm the difference of Raynaud phenomenon and finger temperature, and confirmed the possibility of secondary diagnosis as a quantitative index of Raynaud's diagnosis.
Keywords
Raynaud phenomenon; Raynaud Syndrome; Raynaud's Syndrome; Diagnosis of Raynaud's Syndrome;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 D. O'Reilly, L. Taylor, K. El-Hadidy, M. Jayson, "Measurement of cold challenge responses in primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis," Annals of the rheumatic diseases, Vol. 51, No. 11, pp. 1193, 1992.   DOI
2 G. de Takats, E. F. Fowler, "Raynaud's phenomenon," The Journal of the American Medical Association, Vol. 179, No. 1, pp. 1-8, 1962.   DOI
3 R. Fries, K. Sharia, H. von Wilmowsky, M. Bohm, "Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy," Circulation, Vol. 112, No. 19, pp. 2980-2985, 2005.   DOI
4 J. E. Pope, "The diagnosis and treatment of Raynaud's phenomenon," Drugs, Vol. 67, No. 4, pp. 517-525, 2007.   DOI
5 B. Arneklo-Nobin, U. Albrechtsson, B. Eklof, U. Tylen, "Indications for angiography and its optimal performance in patients with Raynaud's phenomenon," Cardiovascular and interventional radiology, Vol. 8, No. 4, pp. 174-179, 1985.   DOI
6 F. I. ngegnoli, N. Ughi, G. Dinsdale, A. Orenti, P. Boracchi, Y. Allanore, et al, "An international Survey on non-invasive techniques to assess the microcirculation in patients with Raynaud's phenomenon (SUNSHINE survey)," Rheumatology international, Vol. 37, No. 11, pp. 1879-1890, 2017.   DOI
7 Y. S. Kim, K. R. Han, J. S. Kim, Y. J. Lee, C. Kim, "Cold-stress test involving finger skin temperature measurement for evaluation of raynaud's disease and nonspecific cold sensitive patients," Korean Journal of Anesthesiology, Vol. 45, No. 5, pp. 566-571, 2003.   DOI
8 C. Matucci-Cerinic, V. Nagaraja, F. Prignano, B. Kahaleh, S. Bellando-Randone, "The role of the dermatologist in Raynaud's phenomenon: a clinical challenge," Journal of the European Academy of Dermatology and Venereology, Vol. 32, No. 7, pp. 1120-1127, 2018.   DOI
9 S. M. Mirbod, H. Sugiura, "A non-invasive technique for the evaluation of peripheral circulatory functions in female subjects with Raynaud's phenomenon," Industrial health, Vol. 55, No. 3, pp. 275-284, 2017.   DOI
10 A. J. Zweifler, P. Trinkaus, "Occlusive digital artery disease in patients with Raynaud's phenomenon," The American journal of medicine, Vol. 77, No. 6, pp. 995-1001, 1984.   DOI
11 S. M. Lim, J. K. Chung, M. C. Lee, S. J. Kim, S. J. Choi, C. S. Koh, "Measurement of Finger Blood Flow in Raynauds Phenomenon by Radionuclide Angiography," Korean Journal of Nuclear Medicine, Vol. 21, No. 2, pp. 183-190, 1987.
12 S. Pavlov-Dolijanovic, N. Petrovic, N. V. Stupar, N. Damjanov, G. Radunovic, D. Babic, et al, "Diagnosis of Raynaud's phenomenon by 99m Tc-pertechnetate hand perfusion scintigraphy: a pilot study," Rheumatology international, Vol. 35, No. 12, pp. 1683-1688, 2016.
13 J. W. Lee, W. S. Jeong, S. M. Lee, J. Kim, "Comparison of the diagnostic performances of two protocols of hand perfusion scin tigraphy for Raynaud's phenomenon," Nucler medicine communications, Vol. 33, No. 10, pp. 1032-1038, 2012.   DOI
14 A. Smyth, A. Bell, I. Bruce, S. McGrann, J. Allen, "Digital vascular responses and serum endothelin-1 concentrations in primary and secondary Raynaud's phenomenon," Annals of the rheumatic diseases, Vol. 59, No. 11, pp. 870-874, 2000.   DOI
15 S. H. Bang, Y. S. Oh, H. J. Park, T. K. Lee, J. S. Yang, S. M. Lee, et al., "Evaluation of finger blood flow with Tc-99m MDP (methylene diphosponate)," The Korean journal of internal medicine, Vol. 7, No. 2, pp. 94, 1992.   DOI
16 D. Ernst, R. Hurlow, C. Strachan, C. Chandler, "The assessment of digital vessel disease by dynamic hand scanning," Hand, Vol. 3, No. 1, pp. 217-225, 1978.
17 M. Kim, "Differences in skin temperature and perceived thermal comfort based on Age, Sex and clothing weight of participants in a room at recommended room temperature," The Korean Journal of Community Living Science, 2004.
18 https://en.wikibooks.org/w/index.php?title=Basic_Physics_of_Nuclear_Medicine&oldid=3439648/
19 J. A. dBlock, W. Sequeira, "Raynaud's phenomenon," The Lancet, Vol. 357, No. 9273, pp. 2042-2048, 2001.   DOI
20 A. L. Herrick, "The pathogenesis, diagnosis and treatment of Raynaud phenomenon," Nature Reviews Rheumatology, Vol. 8, No. 8, pp. 469, 2012.   DOI
21 G. A. Giurgea, W. Mlekusch, S. Charwat‐Resl, M. Mueller, A. Hammer, M. E. Gschwandtner, et al, "Brief report: Relationship of age and body mass index to skin temperature and skin perfusion in primary Raynaud's phenomenon," Arthritis & Rheumatology, Vol. 67, No. 1, pp. 238-242, 2015.   DOI
22 O. Schlager, M. E. Gschwandtner, K. Herberg, T. Frohner, M. Schillinger, R. Koppensteiner, et al, "Correlation of infrared thermography and skin perfusion in Raynaud patients and in healthy controls," Microvascular research, Vol. 80, No. 1, pp. 54-57, 2010.   DOI