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http://dx.doi.org/10.7742/jksr.2018.12.5.565

A Study of Targetry Activation and Dose Analysis of PET Cyclotron Using Monte Carlo Simulation  

Jang, Donggun (Department of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer center)
Kim, Dong hyun (Department of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Publication Information
Journal of the Korean Society of Radiology / v.12, no.5, 2018 , pp. 565-573 More about this Journal
Abstract
Cyclotron for medical purposes generates nuclear reaction by accelerating protons in high speed, in order to produce radiopharmaceuticals, and unnecessary neutrons are generated through such nuclear reaction. Neutrons cause activation in the parts of cyclotron which then cause exposure to radiation for people working in the field. This study, in that regard, aims to analyze exposure level by finding out the degree of activation of aluminum body, silver body, and havar foil which are the parts of Targetry where the nuclear reaction takes place. The results of the experiment showed that aluminum body and silver body had no problems re-using them as the energy and half-life of activated nuclides were small and short, making the affect on the people working in the field extremely low. However for havar foil, its activated nuclides had a high level of energy which resulted in high level of affect to the people working in the field. The activation factors of the cyclotron were analyzed, and the results showed that the Havar foil was activated the most among the targetry parts, and greatly exposed workers due to regular replacement, and needed special management as radioactive waste.
Keywords
Cyclotron; Activation; Targetry;
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  • Reference
1 The Korean Socity of Nuclear Medicine, "Nuclear medicine scan statistics," 2013.
2 Birattari C., Cantone M.C., Ferrari A., Silari M., "Residual radioactivityat the Milan AVF cyclotron," Nucl. Instrum Methods., Vol. 43, No. 1, pp. 119-126, 1989.   DOI
3 Silari, M., "Special radiation protection aspects of medical accelerators," Radiat. Prot. Dosim. Vol. 96, No. 4, pp.381-392, 2001.   DOI
4 Kondo K., Hirayama H., Ban S., Taino M., Ishii H., "Induced radioactivities in concrete constituents irradiated by high-energy particles," Health Phys., Vol. 46, No. 6, pp.1221-1239, 1984.   DOI
5 Marengo M., Lodi F., Magi S., Cicoria G., Pancaldi D., Boschi S., "Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) routine production," Appl. Radiat. Isot., Vol. 66, No. 3, pp. 295-302, 2008.   DOI
6 Ito S., Sakane H., Deji S., Saze T., Nishizawa K., "Radioactive by products in [18O]H2O used to produce 18F for [18F]FDG synthesis," Appl. Radiat. Isot., Vol. 64, No. 3, pp. 298-305, 2006.   DOI
7 Gillies J. M., Najim N., Zweit J., "Analysis of metal radioisotope impurities generated in [18O]H2O during the cyclotron production of fluorine-18," Appl. Radiat. Isot., Vol. 64, No. 4, pp. 431-34, 2006.   DOI
8 Mochizuki S., Ogata Y., Hatano K., Abe J., Ito K., et al., "Measurement of the Induced Radionuclides in Production of Radiopharmaceuticals for Positron Emission Tomography," J. Nucl. Sci. Technol., Vol. 43, No. 4, pp.348-353, 2006.   DOI
9 National Council on Radiation Protection and Measurements, "Radiation Protection for Particle Accelerator Facilities," NCRP-144, 2003.
10 United Nations Scientific Committee on the Effects of Atomic Radiation, "Sources and Effects of Ionizing Radiation," UNSCEAR 2008 Report Vol. I, 2010.
11 O'Donnell R.G., Vintro L.L, Duffy G.J, Mitchell P.I., "Measurement of the residual radioactivity induced in the front foil of a target assembly in a modern medical cyclotron," Appl. Radiat. Isot., Vol. 60, No. 2-4, pp. 539-542, 2004.   DOI
12 Bowden L., Vintro L.L., Mitchell P.I., O'Donnell R.G., Seymour A.M., Duffy G.J., "Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F-: activities and distribution in the [18F]FDG synthes is process," Appl. Radiat. Isot., Vol. 67, No. 2, pp. 248-255, 2009.   DOI
13 Manickam V., Brey R.R., Jenkins P.A., Christian, P.E., "Measurements of activation products associated with Havar foils from a GE PETtrace medical cyclotron using high resolution gamma spectroscopy," Health Phys., Vol. 96, No. 2, pp. S37-S42, 2009.   DOI
14 Martinez-Serrano J. J., De los Rios A. D., "Predicting Induced Activity in the Havar Foils of the 18F Production Targets of a PET Cyclotron and Derived Radiological Risk," Health Phys., Vol. 107, No. 3, pp. 103-110, 2014.   DOI
15 GE Healthcare, "PETtracer 800 cyclotron series Dara sheet," 2010.
16 Ferrari A., Sala P., Fasso A., Ranft J., "FLUKA: A Multi-Particle Transport Code," CERN-2005-10, INFN/TC_05/11, SLAC-R-773, 2005.
17 Pelowitz D.B., "MCNPX user's manual version 2.5.0," Los Alamos National Laboratory, 2005.
18 GE Healthcare, "PETtracer 800 series Service Manual-Accelerator," Direction 2169047-100, Rev. 22, 2005.
19 IAEA Safety Standards series, "Application of the Concepts of Exclision, Exemption and Clearance," No. RS-G-1.7, 2004.
20 Tewson T.J., Berridge M.S., Bolomey L., Gould K.L., "Routine production of reactive fluorine-18 fluoride salts from an oxygen-18 water target," Nucl. Med. Biol., Vol. 15, No. 5, pp. 499-504, 1988.
21 Berridge M.S., Kjellstrom R., "Designs and use of silver [18O]water targets for [18F]fluoride production," Appl. Radiat. Isot., Vol. 50, No. 4, pp. 699-705, 1999.   DOI