Browse > Article
http://dx.doi.org/10.7742/jksr.2016.10.6.387

TRAIL and Effect of Irradiation on Apoptosis of Cancer Cells  

Lee, Jaeseob (Department of Radiologoical Technology, Gwangyang Health College)
Jang, Seongjoo (Dept. of Radiological Technology, Dongshin University)
Publication Information
Journal of the Korean Society of Radiology / v.10, no.6, 2016 , pp. 387-393 More about this Journal
Abstract
Tumor using the efficient concomitant radiotherapy and chemotherapy to remove, prior to surgery and, either reduce the size of the tumor after surgery, or was can be made smaller, Or excised tumor, in a way to be removed, most conventional surgical method is surgical excision surgery therapy. And methods reduce or tumor size, or smaller, chemotherapy can kill tumor is administered selectively anticancer agent which increases the radioactive susceptible to tumor cells, sensitive to susceptibility to radiation are those which make it possible to respond to, either TRAIL methods of various biological cytostatic can deform the protein, by deforming the structure of the protein help to cell death it is known. In this paper, the HCT-116 cells thought to be a cancer cell to analyze the interaction of TRAIL and radiation. Experimental results, single use of TRAIL and radiation, results were compared with the control group, it was found to have no significant effect on each cell proliferation and apoptosis. Conversely treated with TRAIL, when treated in parallel radiation, it was possible to know that the HCT-116 cells significantly apoptosis occurs, The proportion of G1 ratio G0 also was found to have increased. TRAIL conclusion is increased apoptosis radiation defensive cells can know that increased radiosensitivity, also possible to alter the cell cycle, reduce cell proliferation ability stepwise it was possible. TRAIL is increased apoptosis, decreased cell proliferative capacity, it is considered to be possible to use as a radiation sensitizer.
Keywords
Proliferation; Apoptosis; Radiosensitizer; HCT 116 cells; TRAIL; Radiation;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Griffith, T.S. and D.H. Lynch, "TRAIL: a molecule with multiple receptors and control mechanisms" Curr. Opin. Immunol, Vol. 10, pp. 559-563, 1998.   DOI
2 Zhang, X.D., A. Franco, K. Myers, C.Gray, T.Nguyen and P.Hersey, "Relation of TNF-related apoptosis in ducing ligand (TRAIL) receptor and FLICE inhibitory protein expression to TRAIL induced apoptosis of melanoma," Cancer Res, Vol. 59, pp. 264-295, 1999.
3 Dongyeon Lee, Seongjin Ko, Sesik Kang, Changsoo Kim, Donghyun Kim, Junghoon Kim, “Dose Evaluation of Childhood Leukemia in Total Body Irradiation,” Journal of Korean Society of Radiology, Vol. 7, No. 4, pp. 259-264, 2013.   DOI
4 Karson S Putt, Grace W Chen, Jennifer M Pearson, Joseph S Sandhorst, Martin S Hoagland, Jung-Taek Kwon, Soon-Kyung Hwang, Hua Jin, Mona I Church well, Myung-Haing Cho, Daniel R Doerge, William G Helferich & Paul J Hergenrother, "Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy," Journal of Nature Chemical Biology, Vol. 2, pp. 543-550, 2006.   DOI
5 David Wallach, Mark Boldin, Eugene Varfolomeev, Rudi Beyaert, Peter Vandenabeele, Walter Fiers, “Cell death induction by receptors of the TNF family: towards a molecular understanding,” Journal of FEBS letters, Vol. 410, No. 1, pp. 96-106, 1997.   DOI
6 Byung Geol Jeong, Soon Young Kim, Kon Joo Lee and Jong Sik Kim, "Up-Regulation of NAG-1 and p21 Genes by Sulforaphane," Journal of Life Science,Vol. 22, No. 3, pp. 360-365, 2012.   DOI
7 Jihae Lee, Kyung-Ja Leeongyeon Lee, "Clinical Factors Predicting the Pathologic Tumor Response after Preoperative Concurrent Chemoradiotherapy for Rectal Cancer," Journal of radiation oncology, Vol. 26, No.4, pp. 213-221, 2008.
8 O'Connell MJ, Martenson JA, Wieand HS, et al. "Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery" N Engl J Med, Vol. 331, pp. 502-507, 1994.   DOI
9 Gastrointestinal Tumor Study Group. "Prolongation of the disease-free interval in surgically treated rectal carcinoma," N Engl J Med, Vol. 312, pp.165-192, 1985.   DOI
10 Krook JE, Moertel CG, Gunderson LL, et al. "Effective surgical adjuvant therapy for high-risk rectal carcinoma," N Engl J Med, Vol. 324, pp. 709-715, 1991.   DOI
11 Gastrointestinal Tumor Study Group. "Radiation therapy and fluoro uracial with or without semustine for the treatment of patients with surgical adjuvant aden ocarcinoma of the rectum," J Clin Oncol, Vol. 10, pp.549-557, 1992.   DOI
12 Wang, S and S. W. El-Deiry "TRAIL and apoptosis induction by TNF-family death receptors" oncogene Vol. 22, pp. 862-863, 2001.
13 French, L.E and J.Tschopp, "The TRAIL to selective tumor death," Nat. Med, Vol. 5, pp. 146-147, 1999.   DOI
14 Srivastava, R.K. "TRAIL/Apo-2L: mechanisms and clinical applications in cancer," Neoplasia Vol. 3, pp. 535-546, 2001.   DOI
15 Anderson, D.M, E.Maraskovsky, W.L.Billingsley, W. C. Dougall, M.E. Tometsko, E.R.Roux, M.C. Teepe, R.F. DuBose, D.Cosman, L.Galibert, "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function," Nature, Vol. 390, 175-179, 1997.   DOI